Inhibition of angiogenesis by interleukin 4

• Published in: The Journal of experimental medicine Vol. 188; no. 6; pp. 1039 - 1046
• Main Authors: Volpert, O V, Fong, T, Koch, A E, Peterson, J D, Waltenbaugh, C, Tepper, R I, Bouck, N P
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 21.09.1998
• Subjects: Adenocarcinoma; Animals; Cell Movement - drug effects; Cell Movement - immunology; Cells, Cultured; Cornea - blood supply; Cornea - drug effects; Cornea - immunology; Culture Media, Conditioned - chemistry; Culture Media, Serum-Free - chemistry; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - immunology; Humans; Immunosuppressive Agents - pharmacology; Injections, Intraperitoneal; Interleukin-4 - administration & dosage; Interleukin-4 - physiology; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - immunology; Rats; Tumor Cells, Cultured

Interleukin (IL)-4, a crucial modulator of the immune system and an active antitumor agent, is also a potent inhibitor of angiogenesis. When incorporated at concentrations of 10 ng/ml or more into pellets implanted into the rat cornea or when delivered systemically to the mouse by intraperitoneal in...