Benefit of a Short Chain Peptide as a Targeting Ligand of Nanocarriers for a Brain-Driven Purpose

• Published in: Pharmaceutics Vol. 13; no. 8; p. 1249
• Main Authors: Lo, Yu-Chen, Lin, Wen-Jen
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 12.08.2021; MDPI
• Subjects: Binding sites; blood brain barrier; Brain cancer; Cancer therapies; Copolymers; glioma; Ligands; Medical prognosis; Molecular weight; nanoparticles; peptide; Peptides; Polyvinyl alcohol; Severe acute respiratory syndrome coronavirus 2; United States > US; Japan; Taiwan

Treatment of glioma remains a critical challenge worldwide, since the therapeutic effect is greatly hindered by poor transportation across the blood brain barrier (BBB) and low penetration into tumor cells. In this study, a peptide-conjugated nano-delivery system was explored for the purpose of glio...