Ingestion of a Dietary Supplement Containing Dehydroepiandrosterone (DHEA) and Androstenedione Has Minimal Effect on Immune Function in Middle-Aged Men

• Published in: Journal of the American College of Nutrition Vol. 22; no. 5; pp. 363 - 371
• Main Authors: Kohut, Marian L, Thompson, James R, Campbell, Jeff, Brown, Greg A, Vukovich, Matthew D, Jackson, Dave A, King, Doug S
• Format: Journal Article
• Language: English
• Published: United States American College of Nutrition 01.10.2003
• Subjects: Adjuvants, Immunologic; androstenedione; Androstenedione - administration & dosage; Blood Chemical Analysis; blood serum; concanavalin A; Cytokines - biosynthesis; Dehydroepiandrosterone - administration & dosage; Dietary Supplements; Double-Blind Method; estradiol; Humans; Immune System - drug effects; Immunity, Cellular - drug effects; ingestion; interferon-gamma; interleukin-10; interleukin-1beta; interleukin-2; interleukin-4; Lymphocyte Activation - drug effects; lymphocyte proliferation; Male; men; Middle Aged; middle-aged adults; mononuclear leukocytes; phytohemagglutinin; Plant Preparations - administration & dosage; prasterone; Serenoa repens; testosterone; Tribulus terrestris

Objective: This study investigated the effects of four weeks of intake of a supplement containing dehydroepiandrosterone (DHEA), androstenedione and herbal extracts on immune function in middle-aged men. Design: Subjects consumed either an oral placebo or an oral supplement for four weeks. The suppl...