Formulation optimization of lyophilized aptamer-gold nanoparticles: Maintained colloidal stability and cellular uptake

• Published in: Heliyon Vol. 10; no. 10; p. e30743
• Main Authors: Saidi, Dalya, Obeidat, Marya, Alsotari, Shrouq, Ibrahim, Abed-Alqader, Al-Buqain, Rula, Wehaibi, Suha, Alqudah, Dana A., Nsairat, Hamdi, Alshaer, Walhan, Alkilany, Alaaldin M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30.05.2024; Elsevier
• Subjects: Aggregation; Aptamer; Cryoprotectants; Gold nanoparticles; Lyophilization; Aggregation; Aptamer; Lyophilization; Gold nanoparticles; Cryoprotectants

Anti-nucleolin (NCL) aptamer AS1411 is the first anticancer aptamer tested in clinical trials. Gold nanoparticles (AuNP) have been widely exploited for various biomedical applications due to their unique functional properties. In this study, we evaluated the colloidal stability and targeting capacit...