Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicenter collaborative study
Paclitaxel/carboplatin chemotherapy for cancer (TC therapy) exhibits neurotoxicity and causes peripheral neuropathy at a high frequency, which is difficult to cope with. In this study, we investigated the efficacy of Goshajinkigan, a traditional Japanese herbal medicine, for TC therapy-induced perip...
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Published in | Experimental and therapeutic medicine Vol. 3; no. 1; pp. 60 - 65 |
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Abstract | Paclitaxel/carboplatin chemotherapy for cancer (TC therapy) exhibits neurotoxicity and causes peripheral neuropathy at a high frequency, which is difficult to cope with. In this study, we investigated the efficacy of Goshajinkigan, a traditional Japanese herbal medicine, for TC therapy-induced peripheral neuropathy. The subjects included in our study were patients with ovarian or endometrial cancer who underwent TC therapy and developed peripheral neuropathy. The patients were randomly divided into Group A, comprising of 14 patients (vitamin B12 treatment), and Group B, comprising of 15 patients (vitamin B12 + Goshajinkigan treatment). The observation period was 6 weeks following treatment initiation, and the evaluation items were as follows: i) the current perception threshold (CPT value) of the peripheral nerve, ii) visual analogue scale for numbness, iii) National Cancer Institute Common Terminology Criteria for Adverse Events v3.0 grade of neurotoxicity, and iv) a questionnaire on the subjective symptoms of peripheral neuropathy (functional assessment of cancer therapy-taxane). These were compared between the groups and no significant differences were noted in any item. However, CTCAE grade 3 neurotoxicity developed in 2 patients (14.3%) after 6 weeks of administration in Group A, whereas no neurotoxicity was observed in Group B. When the change in the frequency of abnormal CPT ratio at 6 weeks of administration from that before treatment was compared between the groups, the frequency of abnormal value was significantly lower in Group B than in Group A (p<0.05). This suggests that Goshajinkigan inhibits the progression of peripheral neuropathy. |
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AbstractList | Paclitaxel/carboplatin chemotherapy for cancer (TC therapy) exhibits neurotoxicity and causes peripheral neuropathy at a high frequency, which is difficult to cope with. In this study, we investigated the efficacy of Goshajinkigan, a traditional Japanese herbal medicine, for TC therapy-induced peripheral neuropathy. The subjects included in our study were patients with ovarian or endometrial cancer who underwent TC therapy and developed peripheral neuropathy. The patients were randomly divided into Group A, comprising of 14 patients (vitamin B12 treatment), and Group B, comprising of 15 patients (vitamin B12 + Goshajinkigan treatment). The observation period was 6 weeks following treatment initiation, and the evaluation items were as follows: i) the current perception threshold (CPT value) of the peripheral nerve, ii) visual analogue scale for numbness, iii) National Cancer Institute Common Terminology Criteria for Adverse Events v3.0 grade of neurotoxicity, and iv) a questionnaire on the subjective symptoms of peripheral neuropathy (functional assessment of cancer therapy-taxane). These were compared between the groups and no significant differences were noted in any item. However, CTCAE grade 3 neurotoxicity developed in 2 patients (14.3%) after 6 weeks of administration in Group A, whereas no neurotoxicity was observed in Group B. When the change in the frequency of abnormal CPT ratio at 6 weeks of administration from that before treatment was compared between the groups, the frequency of abnormal value was significantly lower in Group B than in Group A (p<0.05). This suggests that Goshajinkigan inhibits the progression of peripheral neuropathy. |
Author | TOMINAGA, EIICHIRO AOKI, DAISUKE SATO, SHINYA TSUNODA, SHINPEI ONOUE, HIROKI KAKU, HIROI SUGIYAMA, TORU TAKADA, ANNA MIURA, FUMIHARU ARAI, TSUTOMU KIGAWA, JUNZO SHOJI, TADAHIRO KUMAGAI, SEISUKE YOSHIZAKI, AKIRA |
AuthorAffiliation | 5 Department of Obstetrics and Gynecology, Keio University Hospital, Tokyo 160-8582, Japan 1 Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 3 Cancer Center, Tottori University Hospital, Tottori 683-8504 4 Department of Obstetrics and Gynecology, Kitasato University Hospital, Kanagawa 252-0375 2 Department of Obstetrics and Gynecology |
AuthorAffiliation_xml | – name: 2 Department of Obstetrics and Gynecology – name: 4 Department of Obstetrics and Gynecology, Kitasato University Hospital, Kanagawa 252-0375 – name: 1 Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – name: 3 Cancer Center, Tottori University Hospital, Tottori 683-8504 – name: 5 Department of Obstetrics and Gynecology, Keio University Hospital, Tokyo 160-8582, Japan |
Author_xml | – sequence: 1 givenname: HIROI surname: KAKU fullname: KAKU, HIROI organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – sequence: 2 givenname: SEISUKE surname: KUMAGAI fullname: KUMAGAI, SEISUKE organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – sequence: 3 givenname: HIROKI surname: ONOUE fullname: ONOUE, HIROKI organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – sequence: 4 givenname: ANNA surname: TAKADA fullname: TAKADA, ANNA organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – sequence: 5 givenname: TADAHIRO surname: SHOJI fullname: SHOJI, TADAHIRO organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – sequence: 6 givenname: FUMIHARU surname: MIURA fullname: MIURA, FUMIHARU organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – sequence: 7 givenname: AKIRA surname: YOSHIZAKI fullname: YOSHIZAKI, AKIRA organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 – sequence: 8 givenname: SHINYA surname: SATO fullname: SATO, SHINYA organization: Department of Obstetrics and Gynecology – sequence: 9 givenname: JUNZO surname: KIGAWA fullname: KIGAWA, JUNZO organization: Cancer Center, Tottori University Hospital, Tottori 683-8504 – sequence: 10 givenname: TSUTOMU surname: ARAI fullname: ARAI, TSUTOMU organization: Department of Obstetrics and Gynecology, Kitasato University Hospital, Kanagawa 252-0375 – sequence: 11 givenname: SHINPEI surname: TSUNODA fullname: TSUNODA, SHINPEI organization: Department of Obstetrics and Gynecology, Kitasato University Hospital, Kanagawa 252-0375 – sequence: 12 givenname: EIICHIRO surname: TOMINAGA fullname: TOMINAGA, EIICHIRO organization: Department of Obstetrics and Gynecology, Keio University Hospital, Tokyo 160-8582, Japan – sequence: 13 givenname: DAISUKE surname: AOKI fullname: AOKI, DAISUKE organization: Department of Obstetrics and Gynecology, Keio University Hospital, Tokyo 160-8582, Japan – sequence: 14 givenname: TORU surname: SUGIYAMA fullname: SUGIYAMA, TORU organization: Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-8505 |
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Cites_doi | 10.2169/internalmedicine.41.1124 10.1016/j.clinph.2004.03.022 10.1200/JCO.1995.13.1.26 10.1002/(SICI)1097-4598(199904)22:4<523::AID-MUS16>3.0.CO;2-1 10.1002/ana.410310114 10.1016/S0006-8993(97)81682-4 10.1055/s-2002-19594 10.1254/jjp.79.169 10.1093/jnci/djh323 10.1023/A:1008353505916 10.1254/jjp.79.387 10.1016/S0006-8993(98)00305-9 10.1002/cncr.23008 10.1093/jjco/hyp100 10.1002/cncr.11578 10.1055/s-0029-1212132 10.1126/science.290.5489.124 10.2169/internalmedicine.41.819 |
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References | 10442192 - Ann Oncol. 1999 Jun;10(6):693-700 10348261 - Semin Oncol. 1999 Apr;26(2 Suppl 7):51-60 9622663 - Brain Res. 1998 Jun 1;794(2):313-9 11797144 - Dtsch Med Wochenschr. 2002 Jan 18;127(3):78-82 15547181 - J Natl Cancer Inst. 2004 Nov 17;96(22):1682-91 11021795 - Science. 2000 Oct 6;290(5489):124-7 19734172 - Jpn J Clin Oncol. 2009 Dec;39(12):847-9 10230868 - Jpn J Pharmacol. 1999 Mar;79(3):387-91 12521200 - Intern Med. 2002 Dec;41(12):1124-9 1543351 - Ann Neurol. 1992 Jan;31(1):76-80 9452187 - Brain Res. 1997 Nov 7;774(1-2):20-6 12413002 - Intern Med. 2002 Oct;41(10):819-22 3490223 - Appl Neurophysiol. 1986;49(1-2):86-91 10202852 - Jpn J Pharmacol. 1999 Feb;79(2):169-75 8712825 - Gan To Kagaku Ryoho. 1996 Feb;23(3):317-25 15261871 - Clin Neurophysiol. 2004 Aug;115(8):1921-4 7799029 - J Clin Oncol. 1995 Jan;13(1):26-32 10595592 - Exp Clin Endocrinol Diabetes. 1999;107(7):421-30 12910528 - Cancer. 2003 Aug 15;98 (4):822-31 17853395 - Cancer. 2007 Nov 1;110(9):2110-8 10204790 - Muscle Nerve. 1999 Apr;22(4):523-31 Boucher (key20180108121034_b13-etm-03-01-0060) 2000; 290 Nishimura (key20180108121034_b5-etm-03-01-0060) 2004; 115 Cascinu (key20180108121034_b16-etm-03-01-0060) 1995; 13 Noda (key20180108121034_b7-etm-03-01-0060) 1996; 23 Kono (key20180108121034_b1-etm-03-01-0060) 2009; 39 Hayakawa (key20180108121034_b11-etm-03-01-0060) 1998; 794 Apfel (key20180108121034_b10-etm-03-01-0060) 1992; 31 American Association of Electrodiagnostic Medicine (key20180108121034_b6-etm-03-01-0060) 1999; 22 Vasey (key20180108121034_b8-etm-03-01-0060) 2004; 96 Eckel (key20180108121034_b19-etm-03-01-0060) 2002; 127 Katims (key20180108121034_b9-etm-03-01-0060) 1986; 49 Contreras (key20180108121034_b12-etm-03-01-0060) 1997; 774 Oishi (key20180108121034_b4-etm-03-01-0060) 2002; 41 Rao (key20180108121034_b18-etm-03-01-0060) 2007; 110 Suzuki (key20180108121034_b21-etm-03-01-0060) 1999; 79 Planting (key20180108121034_b15-etm-03-01-0060) 1999; 10 Suzuki (key20180108121034_b20-etm-03-01-0060) 1999; 79 Selvaggi (key20180108121034_b14-etm-03-01-0060) 1999; 26 Ziegler (key20180108121034_b17-etm-03-01-0060) 1999; 107 Cella (key20180108121034_b2-etm-03-01-0060) 2003; 15 Takekuma (key20180108121034_b3-etm-03-01-0060) 2002; 41 |
References_xml | – volume: 41 start-page: 1124 year: 2002 ident: key20180108121034_b3-etm-03-01-0060 article-title: Prevalence of hyperesthesia detected by current perception threshold test in subjects with glucose metabolic impairments in a community publication-title: Intern Med doi: 10.2169/internalmedicine.41.1124 contributor: fullname: Takekuma – volume: 115 start-page: 1921 year: 2004 ident: key20180108121034_b5-etm-03-01-0060 article-title: A correlative electrophysiologic study of nerve fiber involvement in carpal tunnel syndrome using current perception thresholds publication-title: Clin Neurophysiol doi: 10.1016/j.clinph.2004.03.022 contributor: fullname: Nishimura – volume: 13 start-page: 26 year: 1995 ident: key20180108121034_b16-etm-03-01-0060 article-title: Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial publication-title: J Clin Oncol doi: 10.1200/JCO.1995.13.1.26 contributor: fullname: Cascinu – volume: 22 start-page: 523 year: 1999 ident: key20180108121034_b6-etm-03-01-0060 article-title: Technology review: the neurometer® current perception threshold (CPT) publication-title: Muscle Nerve doi: 10.1002/(SICI)1097-4598(199904)22:4<523::AID-MUS16>3.0.CO;2-1 contributor: fullname: American Association of Electrodiagnostic Medicine – volume: 23 start-page: 317 year: 1996 ident: key20180108121034_b7-etm-03-01-0060 article-title: Phase II study of paclitaxel (BMS-181339) in patients with ovarian cancer by 3-hour intravenous infusion publication-title: Gan To Kagaku Ryoho contributor: fullname: Noda – volume: 31 start-page: 76 year: 1992 ident: key20180108121034_b10-etm-03-01-0060 article-title: Nerve growth factor prevents experimental cisplatin neuropathy publication-title: Ann Neurol doi: 10.1002/ana.410310114 contributor: fullname: Apfel – volume: 49 start-page: 86 year: 1986 ident: key20180108121034_b9-etm-03-01-0060 article-title: Transcutaneous nerve stimulation. Frequency and waveform specificity in humans publication-title: Appl Neurophysiol contributor: fullname: Katims – volume: 774 start-page: 20 year: 1997 ident: key20180108121034_b12-etm-03-01-0060 article-title: Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice publication-title: Brain Res doi: 10.1016/S0006-8993(97)81682-4 contributor: fullname: Contreras – volume: 127 start-page: 78 year: 2002 ident: key20180108121034_b19-etm-03-01-0060 article-title: Prevention of oxaliplatin-induced neuropathy by carbamazepine. A pilot study publication-title: Dtsch Med Wochenschr doi: 10.1055/s-2002-19594 contributor: fullname: Eckel – volume: 79 start-page: 169 year: 1999 ident: key20180108121034_b20-etm-03-01-0060 article-title: Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice publication-title: Jpn J Pharmacol doi: 10.1254/jjp.79.169 contributor: fullname: Suzuki – volume: 96 start-page: 1682 year: 2004 ident: key20180108121034_b8-etm-03-01-0060 article-title: Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djh323 contributor: fullname: Vasey – volume: 10 start-page: 693 year: 1999 ident: key20180108121034_b15-etm-03-01-0060 article-title: Randomized study of a short course of weekly cisplatin with or without amifostine in advanced head and neck cancer publication-title: Ann Oncol doi: 10.1023/A:1008353505916 contributor: fullname: Planting – volume: 26 start-page: 51 year: 1999 ident: key20180108121034_b14-etm-03-01-0060 article-title: Carboplatin and paclitaxel in non-small cell lung cancer: the role of amifostine publication-title: Semin Oncol contributor: fullname: Selvaggi – volume: 79 start-page: 387 year: 1999 ident: key20180108121034_b21-etm-03-01-0060 article-title: Antinociceptive mechanism of Gosha-jinki-gan in streptozotocin-induced diabetic animals: role of nitric oxide in the periphery publication-title: Jpn J Pharmacol doi: 10.1254/jjp.79.387 contributor: fullname: Suzuki – volume: 794 start-page: 313 year: 1998 ident: key20180108121034_b11-etm-03-01-0060 article-title: NGF prevention of neurotoxicity induced by cisplatin, vincristine and taxol depends on toxicity of each drug and NGF treatment schedule: in vitro study of adult rat sympathetic ganglion explants publication-title: Brain Res doi: 10.1016/S0006-8993(98)00305-9 contributor: fullname: Hayakawa – volume: 110 start-page: 2110 year: 2007 ident: key20180108121034_b18-etm-03-01-0060 article-title: Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3) publication-title: Cancer doi: 10.1002/cncr.23008 contributor: fullname: Rao – volume: 39 start-page: 847 year: 2009 ident: key20180108121034_b1-etm-03-01-0060 article-title: Preventive effect of goshajinkigan on peripheral neurotoxicity of FOLFOX therapy: a placebo-controlled double-blind randomized phase II study (the GONE Study) publication-title: Jpn J Clin Oncol doi: 10.1093/jjco/hyp100 contributor: fullname: Kono – volume: 15 start-page: 822 year: 2003 ident: key20180108121034_b2-etm-03-01-0060 article-title: Measuring the side effects of taxane therapy in oncology: the functional assesment of cancer therapy-taxane (FACT-taxane) publication-title: Cancer doi: 10.1002/cncr.11578 contributor: fullname: Cella – volume: 107 start-page: 421 year: 1999 ident: key20180108121034_b17-etm-03-01-0060 article-title: Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials publication-title: Exp Clin Endocrinol Diabetes doi: 10.1055/s-0029-1212132 contributor: fullname: Ziegler – volume: 290 start-page: 124 year: 2000 ident: key20180108121034_b13-etm-03-01-0060 article-title: Potent analgesic effects of GDNF in neuropathic pain states publication-title: Science doi: 10.1126/science.290.5489.124 contributor: fullname: Boucher – volume: 41 start-page: 819 year: 2002 ident: key20180108121034_b4-etm-03-01-0060 article-title: Current perception threshold and sympathetic skin response in diabetic and alcoholic polyneuropathies publication-title: Intern Med doi: 10.2169/internalmedicine.41.819 contributor: fullname: Oishi |
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SubjectTerms | Goshajinkigan gynecological cancer Japanese herbal medicine kampo drugs neurotoxicity paclitaxel peripheral neuropathy |
Title | Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicenter collaborative study |
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