Polyglutamine tracts as modulators of transcriptional activation from yeast to mammals

• Published in: Biological chemistry Vol. 393; no. 1-2; pp. 63 - 70
• Main Authors: Atanesyan, Lilit, Günther, Viola, Dichtl, Bernhard, Georgiev, Oleg, Schaffner, Walter
• Format: Journal Article
• Language: English
• Published: Germany Walter de Gruyter 01.01.2012; De Gruyter
• Subjects: Animals; Cells, Cultured; Drosophila; evolvability; Glutamine - genetics; Glutamine - metabolism; HEK293 Cells; Humans; Mammals - genetics; Mammals - metabolism; Peptides - genetics; Peptides - metabolism; polyglutamine repeat; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; transcription factor; Transcription Factors - chemistry; Transcription Factors - metabolism; Transcriptional Activation - genetics; triplet repeat; Two-Hybrid System Techniques
• ISSN: 1431-6730; 1437-4315; 1437-4315
• DOI: 10.1515/BC-2011-252

Microsatellite repeats are genetically unstable and subject to expansion and shrinkage. A subset of them, triplet repeats, can occur within the coding region and specify homomeric tracts of amino acids. Polyglutamine (polyQ) tracts are enriched in eukaryotic regulatory proteins, notably transcriptio...