The challenges for molecular nutrition research 2: quantification of the nutritional phenotype

• Published in: Genes & nutrition Vol. 3; no. 2; pp. 51 - 59
• Main Authors: van Ommen, Ben, Keijer, Jaap, Kleemann, Robert, Elliott, Ruan, Drevon, Christian A., McArdle, Harry, Gibney, Mike, Müller, Michael
• Format: Journal Article
• Language: English
• Published: Germany Springer-Verlag 01.07.2008
• Subjects: biomarkers; blood mononuclear-cells; body-temperature; c-reactive protein; cardiovascular-disease; developmental origins; diet-related diseases; food intake; gene-expression profiles; genotype; healthy-volunteers; homeostasis; image analysis; in-vivo; metabolic syndrome; nutrition research; nutritional intervention; phenotype; Review; systems biology

In quantifying the beneficial effect of dietary interventions in healthy subjects, nutrition research meets a number of new challenges. Inter individual variation in biomarker values often is larger than the effect related to the intervention. Healthy subjects have a remarkable capacity to maintain...