Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population

• Published in: Human molecular genetics Vol. 20; no. 3; pp. 615 - 627
• Main Authors: Saad, M., Lesage, S., Saint-Pierre, A., Corvol, J.-C., Zelenika, D., Lambert, J.-C., Vidailhet, M., Mellick, G. D., Lohmann, E., Durif, F., Pollak, P., Damier, P., Tison, F., Silburn, P. A., Tzourio, C., Forlani, S., Loriot, M.-A., Giroud, M., Helmer, C., Portet, F., Amouyel, P., Lathrop, M., Elbaz, A., Durr, A., Martinez, M., Brice, A., Agid, Y., Anheim, M., Bonnet, A.- M., Borg, M., Broussolle, E., Corvol, J.- C., Destee, A., Klebe, S., Penet, C., Rascol, O., Tranchant, C., Verin, M., Viallet, F.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2011
• Subjects: ADP-ribosyl Cyclase - genetics; Adult; Aged; Antigens, CD - genetics; Biological and medical sciences; Brain; Case-Control Studies; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 4; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Europe - epidemiology; Female; Fundamental and applied biological sciences. Psychology; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Genotype; GPI-Linked Proteins - genetics; Humans; Male; Medical sciences; Middle Aged; Molecular and cellular biology; Neurology; Parkinson Disease - epidemiology; Parkinson Disease - genetics; Polymorphism, Single Nucleotide; Risk Factors; Transcription Factors; Europe; Human; Nervous system diseases; Parkinson disease; Risk; Chromosome C12; European; Cerebral disorder; Association; Central nervous system disease; Risk factor; Genetics; Degenerative disease; Locus; Extrapyramidal syndrome

We performed a three-stage genome-wide association study (GWAS) to identify common Parkinson's disease (PD) risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1039 cases and 1984 controls, using almost 500 000 single nucleotide polymorphis...