Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

• Published in: Brain (London, England : 1878) Vol. 141; no. 4; pp. 1186 - 1200
• Main Authors: Franzmeier, Nicolai, Düzel, Emrah, Jessen, Frank, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Haass, Christian, Suárez-Calvet, Marc, Fagan, Anne M, Paumier, Katrina, Benzinger, Tammie, Masters, Colin L, Morris, John C, Perneczky, Robert, Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Teipel, Stefan, Kilimann, Ingo, Ramirez, Alfredo, Rossor, Martin, Jucker, Mathias, Chhatwal, Jasmeer, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Falkai, Peter, Fliessbach, Klaus, Heneka, Michael T, Laske, Christoph, Nestor, Peter, Peters, Oliver, Fuentes, Manuel, Menne, Felix, Priller, Josef, Spruth, Eike J, Franke, Christiana, Schneider, Anja, Kofler, Barbara, Westerteicher, Christine, Speck, Oliver, Wiltfang, Jens, Bartels, Claudia, Araque Caballero, Miguel Ángel, Metzger, Coraline, Bittner, Daniel, Weiner, Michael, Lee, Jae-Hong, Salloway, Stephen, Danek, Adrian, Goate, Alison, Schofield, Peter R, Bateman, Randall J, Ewers, Michael
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2018
• Subjects: Adult; Alzheimer Disease - complications; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Amyloid beta-Protein Precursor - genetics; Brain Mapping; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - etiology; Female; Frontal Lobe - diagnostic imaging; Functional Laterality - physiology; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle Aged; Mutation - genetics; Nerve Net - diagnostic imaging; Nerve Net - physiology; Original; Presenilin-1 - genetics; Presenilin-2 - genetics; memory; dementia biomarkers; Alzheimer's disease; resting state connectivity; cognitive reserve

The neural basis of reserve capacity in Alzheimer's disease is yet to be fully determined. Franzmeier et al. show that greater left frontal hub connectivity within the fronto-parietal control network is associated with greater resilience of cognitive performance during the early stages of autos...