Triglyceride-Lowering Effects of a Modest Dose of Docosahexaenoic Acid Alone Versus in Combination with Low Dose Eicosapentaenoic Acid in Patients with Coronary Artery Disease and Elevated Triglycerides

• Published in: Journal of the American College of Nutrition Vol. 25; no. 6; pp. 480 - 485
• Main Authors: Schwellenbach, Lisa J, Olson, Kari L, McConnell, Karen J, Stolcpart, Ryan S, Nash, James D, Merenich, John A
• Format: Journal Article
• Language: English
• Published: United States American College of Nutrition 01.12.2006
• Subjects: Aged; blood lipids; cardioprotective effect; cardiovascular diseases; Coronary Artery Disease - blood; Coronary Artery Disease - drug therapy; dietary supplements; Docosahexaenoic Acids - therapeutic use; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Eicosapentaenoic Acid - therapeutic use; Female; human nutrition; Humans; hypertriglyceridemia; Hypertriglyceridemia - drug therapy; lipemic effect; Lipid Metabolism - drug effects; Male; nutritional intervention; omega-3 fatty acids; patients; polyunsaturated fatty acids; Prospective Studies; randomized clinical trials; Risk Factors; Treatment Outcome; triacylglycerols; Triglycerides - blood

BACKGROUND: Hypertriglyceridemia is a risk factor for coronary artery disease (CAD). The American Heart Association recommends 1000 mg of omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), daily for cardioprotection and higher doses for triglyceride-lowering in patients...