Abnormal Nasal Nitric Oxide Production, Ciliary Beat Frequency, and Toll-like Receptor Response in Pulmonary Nontuberculous Mycobacterial Disease Epithelium

• Published in: American journal of respiratory and critical care medicine Vol. 187; no. 12; pp. 1374 - 1381
• Main Authors: Fowler, Cedar J., Olivier, Kenneth N., Leung, Janice M., Smith, Caroline C., Huth, Andrea G., Root, Heather, Kuhns, Douglas B., Logun, Carolea, Zelazny, Adrian, Frein, Cathleen A., Daub, Janine, Haney, Carissa, Shelhamer, James H., Bryant, Clare E., Holland, Steven M.
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.06.2013
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Bacterial diseases; Biological and medical sciences; Cilia - physiology; Cystic fibrosis; Disease; Dyskinesia; Female; Human bacterial diseases; Humans; Infections; Infectious diseases; Intensive care medicine; Lung Diseases - metabolism; Lung Diseases - microbiology; Lung Diseases - physiopathology; Male; Medical sciences; Middle Aged; Mutation; Mycobacterium Infections, Nontuberculous - metabolism; Mycobacterium Infections, Nontuberculous - physiopathology; Nitric oxide; Nitric Oxide - biosynthesis; Nose; Patients; Pneumology; Respiratory Mucosa - physiopathology; Toll-Like Receptors - physiology; Tuberculosis and atypical mycobacterial infections; Womens health; Lung disease; Intensive care; Beat frequency; Respiratory disease; Toll like receptor; Nasopharynx; Mycobacterial infection; Epithelium; Differential diagnostic; nontuberculous mycobacteria infections; Infection; Nitric oxide; Nose; Production; nasal nitric oxide; Bacteriosis; Toll-like receptors; cilia beat frequency; Frequency response; Resuscitation; Cilia

Pulmonary nontuberculous mycobacterial (PNTM) disease has increased over the past several decades, especially in older women. Despite extensive investigation, no consistent immunological abnormalities have been found. Using evidence from diseases such as cystic fibrosis and primary ciliary dyskinesi...