Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice

• Published in: Behavioural brain research Vol. 258; pp. 8 - 18
• Main Authors: Lin, Nan, Pan, Xiao-dong, Chen, Ai-qin, Zhu, Yuan-gui, Wu, Ming, Zhang, Jing, Chen, Xiao-chun
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.01.2014; Elsevier
• Subjects: Aging; Aging - drug effects; Aging - metabolism; Animals; Behavioral psychophysiology; Biological and medical sciences; Cognition; Cognition - drug effects; Cognition Disorders - drug therapy; Cognition Disorders - metabolism; Cognition Disorders - physiopathology; Diterpenes - pharmacology; Diterpenes - therapeutic use; Fundamental and applied biological sciences. Psychology; Hippocampus - drug effects; Hippocampus - physiopathology; Long-term potentiation; Male; Maze Learning - drug effects; Mice; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; NMDA receptor; Phenanthrenes - pharmacology; Phenanthrenes - therapeutic use; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Receptors, N-Methyl-D-Aspartate - metabolism; Synapses - drug effects; Synapses - physiology; Synaptic plasticity; Tripchlorolide; Vertebrates: nervous system and sense organs; T4; MWM; AD; BDNF; Long-term potentiation; LTP; Cognition; Tripchlorolide; CaMKII; CREB; SAMP8; Synaptic plasticity; Aging; NMDAR; EPSPs; PSD-95; NMDA receptor; Senescence; Cognitive disorder; Rodentia; Central nervous system; Glutamate receptor; Encephalon; Vertebrata; Mammalia; Mouse; Animal; Age; Hippocampus; Morris water maze; cyclic AMP-response element binding protein; excitatory postsynaptic potentials; T; brain-derived neurotrophic factor; N-methyl-d-aspartate receptor; calcium/calmodulin-dependent protein kinase II; postsynaptic density-95; Alzheimer's Disease; senescence-accelerated mouse Prone 8 SAMR1

•A novel extract of natural herbal, tripchlorolide has anti-dementia action.•Long-term T4 treatment prevents learning and memory loss in aged SAMP8 mice.•T4 ameliorates hippocampal LTP in aged SAMP8 mice.•T4 alleviates synaptic plasticity dysfunction of the hippocampus.•T4 intensified the signal pat...