Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice - Lin, Nan; Pan, Xiao-dong; Chen, Ai-qin; Zhu, Yuan-gui; Wu, Ming; Zhang, Jing; Chen, Xiao-chun (Behavioural brain research, 2014)
Keywords: Aging; Aging - drug effects; Aging - metabolism; Animals; Behavioral psychophysiology; Biological and medical sciences; Cognition; Cognition - drug effects; Cognition Disorders - drug therapy; Cognition Disorders - metabolism; Cognition Disorders - physiopathology; Diterpenes - pharmacology; Diterpenes - therapeutic use; Fundamental and applied biological sciences. Psychology; Hippocampus - drug effects; Hippocampus - physiopathology; Long-term potentiation; Male; Maze Learning - drug effects; Mice; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; NMDA receptor; Phenanthrenes - pharmacology; Phenanthrenes - therapeutic use; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Receptors, N-Methyl-D-Aspartate - metabolism; Synapses - drug effects; Synapses - physiology; Synaptic plasticity; Tripchlorolide; Vertebrates: nervous system and sense organs; T4; MWM; AD; BDNF; Long-term potentiation; LTP; Cognition; Tripchlorolide; CaMKII; CREB; SAMP8; Synaptic plasticity; Aging; NMDAR; EPSPs; PSD-95; NMDA receptor; Senescence; Cognitive disorder; Rodentia; Central nervous system; Glutamate receptor; Encephalon; Vertebrata; Mammalia; Mouse; Animal; Age; Hippocampus; Morris water maze; cyclic AMP-response element binding protein; excitatory postsynaptic potentials; T; brain-derived neurotrophic factor; N-methyl-d-aspartate receptor; calcium/calmodulin-dependent protein kinase II; postsynaptic density-95; Alzheimer's Disease; senescence-accelerated mouse Prone 8 SAMR1