Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

• Published in: Science (American Association for the Advancement of Science) Vol. 334; no. 6061; pp. 1420 - 1424
• Main Authors: Takeda, Norifumi, Jain, Rajan, LeBoeuf, Matthew R., Wang, Qiaohong, Lu, Min Min, Epstein, Jonathan A.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 09.12.2011; The American Association for the Advancement of Science
• Subjects: Animals; Biological and medical sciences; Cell Cycle; Cell Differentiation; Cell Lineage; Cell Proliferation; Cells; Cells, Cultured; Crypts; Cultured cells; Descendants; Endocrine cells; Epithelial cells; Epithelial Cells - cytology; Fundamental and applied biological sciences. Psychology; Homeodomain Proteins - analysis; Homeodomain Proteins - genetics; Intestinal Mucosa - cytology; Intestinal Mucosa - drug effects; Intestine, Small - cytology; Intestine, Small - drug effects; Intestine. Mesentery; Intestines; Mice; Models, Biological; Multipotent Stem Cells - cytology; Multipotent Stem Cells - physiology; Neural stem cells; Organoids; Paneth Cells - cytology; Stem Cell Niche; Stem cells; Tamoxifen - pharmacology; Vertebrates: digestive system; Interconversion; Digestive system; Stem cell; Rodentia; Gut; Vertebrata; Mammalia; Lieberkuhn gland; Mouse; Animal; Genetics; Epithelial cell; Homeobox gene

Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cel...