HLA-DRB111 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 52; pp. 15970 - 15975
• Main Authors: Ombrello, Michael J., Remmers, Elaine F., Tachmazidou, Ioanna, Grom, Alexei, Foell, Dirk, Haas, Johannes-Peter, Martini, Alberto, Gattorno, Marco, Özen, Seza, Prahalad, Sampath, Zeft, Andrew S., Bohnsack, John F., Mellins, Elizabeth D., Ilowite, Norman T., Russo, Ricardo, Len, Claudio, Hilario, Maria Odete E., Oliveira, Sheila, Yeung, Rae S. M., Rosenberg, Alan, Wedderburn, Lucy R., Anton, Jordi, Schwarz, Tobias, Hinks, Anne, Bilginer, Yelda, Park, Jane, Cobb, Joanna, Satorius, Colleen L., Han, Buhm, Baskin, Elizabeth, Signa, Sara, Duerr, Richard H., Achkar, J. P., Kamboh, M. Ilyas, Kaufman, Kenneth M., Kottyan, Leah C., Pinto, Dalila, Scherer, Stephen W., Alarcón-Riquelme, Marta E., Docampo, Elisa, Estivill, Xavier, Gül, Ahmet, de Bakker, Paul I. W., Raychaudhuri, Soumya, Langefeld, Carl D., Thompson, Susan, Zeggini, Eleftheria, Thomson, Wendy, Kastner, Daniel L., Woo, Patricia, Allen, Roger, Berg, Stefan, Bica, Bianca, Cavalcanti, Andre, Chaitow, Jeffrey, Cuttica, Rubin, Duerr, Richard, Ellis, Justine, Finkel, Terri H., Hakonarson, Hakon, Kaufman, Kenneth, Langefeld, Carl, Minden, Kirstin, Murray, Kevin, Ozen, Seza, Quartier, Pierre, Satorius, Colleen
• Format: Journal Article Web Resource
• Language: English
• Published: United States National Acad Sciences 29.12.2015; National Academy of Sciences
• Series: From the Cover
• Subjects: Amino acids; Arthritis; Arthritis, Juvenile - genetics; autoinflammation; Biological Sciences; Child; Gene Frequency; Genes; Genetic diversity; Genetic Predisposition to Disease - genetics; Genetics & genetic processes; Genotype; Genotypes; Génétique & processus génétiques; Haplotypes; Histocompatibility Antigens Class II - genetics; HLA-DRB1 Chains - genetics; human leukocyte antigen; Humans; Life sciences; Linkage Disequilibrium; Meta-analysis; Meta-Analysis as Topic; Molecules; Odds Ratio; Pathogenesis; Polymorphism, Single Nucleotide; Risk Factors; Sciences du vivant; Still's disease; systemic juvenile idiopathic arthritis; systemic juvenile idiopathic arthritis; autoinflammation; human leukocyte antigen; Still’s disease

To determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent...