Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells
Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of leptin receptors produced by alternative mRNA splicing are found in many tissues, including the hypothalamus, liver, lung, kidney, hematopoietic cells, and gonads, suggesting that leptin exerts effects in thes...
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| Published in | The Journal of biological chemistry Vol. 272; no. 20; pp. 12897 - 12900 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
16.05.1997
American Society for Biochemistry and Molecular Biology |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of leptin receptors produced by alternative mRNA splicing are found in many tissues, including the hypothalamus, liver, lung, kidney, hematopoietic cells, and gonads, suggesting that leptin exerts effects in these tissues. In accordance with the distribution of leptin receptors, there is accumulating evidence that leptin plays various roles in reproduction, hematopoiesis, and the immune systems in addition to the regulation of food intake and energy expenditure. In the present study, we examined the in vitro effects of leptin on proliferation of a mouse embryonic cell line, C3H10T1/2, and its mechanism of action. Leptin caused a dose- and time-dependent increase in mitogen-activated protein kinase (MAPK) activity that was accompanied by an increase in C3H10T1/2 cell number. The MAPK kinase-1-specific inhibitor PD98059 completely blocked the increases in both MAPK activity and cell proliferation caused by leptin. These findings indicate that leptin stimulates the proliferation of C3H10T1/2 cells via the MAPK cascade. |
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| AbstractList | Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of leptin receptors produced by alternative mRNA splicing are found in many tissues, including the hypothalamus, liver, lung, kidney, hematopoietic cells, and gonads, suggesting that leptin exerts effects in these tissues. In accordance with the distribution of leptin receptors, there is accumulating evidence that leptin plays various roles in reproduction, hematopoiesis, and the immune systems in addition to the regulation of food intake and energy expenditure. In the present study, we examined the in vitro effects of leptin on proliferation of a mouse embryonic cell line, C3H10T1/2, and its mechanism of action. Leptin caused a dose- and time-dependent increase in mitogen-activated protein kinase (MAPK) activity that was accompanied by an increase in C3H10T1/2 cell number. The MAPK kinase-1-specific inhibitor PD98059 completely blocked the increases in both MAPK activity and cell proliferation caused by leptin. These findings indicate that leptin stimulates the proliferation of C3H10T1/2 cells via the MAPK cascade. Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of leptin receptors produced by alternative mRNA splicing are found in many tissues, including the hypothalamus, liver, lung, kidney, hematopoietic cells, and gonads, suggesting that leptin exerts effects in these tissues. In accordance with the distribution of leptin receptors, there is accumulating evidence that leptin plays various roles in reproduction, hematopoiesis, and the immune systems in addition to the regulation of food intake and energy expenditure. In the present study, we examined the in vitro effects of leptin on proliferation of a mouse embryonic cell line, C3H10T1/2, and its mechanism of action. Leptin caused a dose- and time-dependent increase in mitogen-activated protein kinase (MAPK) activity that was accompanied by an increase in C3H10T1/2 cell number. The MAPK kinase-1-specific inhibitor PD98059 completely blocked the increases in both MAPK activity and cell proliferation caused by leptin. These findings indicate that leptin stimulates the proliferation of C3H10T1/2 cells via the MAPK cascade. |
| Author | Okimura, Yasuhiko Takahashi, Tetsuya Abe, Hiromi Kaji, Hidesuke Chihara, Kazuo Mizuno, Ishikazu Takahashi, Yutaka Iida, Keiji |
| Author_xml | – sequence: 1 givenname: Yutaka surname: Takahashi fullname: Takahashi, Yutaka – sequence: 2 givenname: Yasuhiko surname: Okimura fullname: Okimura, Yasuhiko – sequence: 3 givenname: Ishikazu surname: Mizuno fullname: Mizuno, Ishikazu – sequence: 4 givenname: Keiji surname: Iida fullname: Iida, Keiji – sequence: 5 givenname: Tetsuya surname: Takahashi fullname: Takahashi, Tetsuya – sequence: 6 givenname: Hidesuke surname: Kaji fullname: Kaji, Hidesuke – sequence: 7 givenname: Hiromi surname: Abe fullname: Abe, Hiromi – sequence: 8 givenname: Kazuo surname: Chihara fullname: Chihara, Kazuo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9148892$$D View this record in MEDLINE/PubMed |
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| Copyright | 1997 © 1997 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. |
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| Snippet | Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of leptin receptors produced by alternative mRNA splicing are found in... Leptin, secreted by adipocytes, regulates satiety and energy expenditure. Several forms of leptin receptors produced by alternative mRNA splicing are found in... |
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| SubjectTerms | Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Division - drug effects Cell Line Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Flavonoids - pharmacology Leptin Mice Pregnancy Proteins - pharmacology Signal Transduction - drug effects |
| Title | Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells |
| URI | https://dx.doi.org/10.1074/jbc.272.20.12897 http://www.jbc.org/content/272/20/12897.abstract https://www.ncbi.nlm.nih.gov/pubmed/9148892 |
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