UBA2 promotes proliferation of colorectal cancer

• Published in: Molecular medicine reports Vol. 18; no. 6; pp. 5552 - 5562
• Main Authors: He, Ping, Sun, Xun, Cheng, Hong-Jing, Zou, Ya-Bin, Wang, Quan, Zhou, Chang-Li, Liu, Wan-Qi, Hao, Yue-Ming, Meng, Xiang-Wei
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.12.2018; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Adult; Aged; AKT protein; Analysis; Animals; Apoptosis; B-cell lymphoma; Cancer; Carcinogenesis; Care and treatment; Cell cycle; Cell Cycle - genetics; Cell growth; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Cyclin B1; Cyclin-dependent kinases; Disease Models, Animal; Enzymes; Female; Flow cytometry; Gene Expression; Genomes; Health aspects; HIV; Human immunodeficiency virus; Humans; Immunohistochemistry; Kinases; Lymphocytes B; Male; MDM2 protein; Medical prognosis; Messenger RNA; Metastasis; Mice; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Oncology, Experimental; Polymerase chain reaction; Prognosis; Proteins; Reverse transcription; Studies; Therapeutic applications; Tumor cell lines; Tumorigenesis; Tumors; Ubiquitin; Ubiquitin-Activating Enzymes - genetics; Ubiquitin-Activating Enzymes - metabolism; Ubiquitin-protein ligase; Western blotting; United States > US; China

Small ubiquitin‑like modifier proteins are involved in tumorigenesis; however, the potential effects and functions of the family member ubiquitin‑like modifier‑activating enzyme 2 (UBA2) on colorectal cancer are not clear. The present study aimed to examine the effects of UBA2 on the proliferation o...