Diffusion Tensor Magnetic Resonance Imaging of Disruption of Regional White Matter in Schizophrenia
Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption of regional white matter in schizophrenia. Twelve patients with schizophrenia were compared with 11 healthy controls. Psychotic symp...
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| Published in | Neuropsychobiology Vol. 47; no. 3; pp. 141 - 145 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel, Switzerland
Karger
01.01.2003
S. Karger AG |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0302-282X 1423-0224 |
| DOI | 10.1159/000070583 |
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| Abstract | Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption of regional white matter in schizophrenia. Twelve patients with schizophrenia were compared with 11 healthy controls. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. A significant fractional anisotropy (FA) reduction was found in all white matter regions bilaterally in schizophrenic patients. Higher FA of left frontal white matter correlated significantly with higher dosage of antipsychotic medication. These findings support the view that the pathological process is a distortion of the central nervous system myelination affecting the whole white matter. Our findings also show the effects of antipsychotics on the white matter in the left frontal region in schizophrenia. |
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| AbstractList | Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption of regional white matter in schizophrenia. Twelve patients with schizophrenia were compared with 11 healthy controls. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. A significant fractional anisotropy (FA) reduction was found in all white matter regions bilaterally in schizophrenic patients. Higher FA of left frontal white matter correlated significantly with higher dosage of antipsychotic medication. These findings support the view that the pathological process is a distortion of the central nervous system myelination affecting the whole white matter. Our findings also show the effects of antipsychotics on the white matter in the left frontal region in schizophrenia. Copyright [copy 2003 S. Karger AG, Basel Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption of regional white matter in schizophrenia. Twelve patients with schizophrenia were compared with 11 healthy controls. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. A significant fractional anisotropy (FA) reduction was found in all white matter regions bilaterally in schizophrenic patients. Higher FA of left frontal white matter correlated significantly with higher dosage of antipsychotic medication. These findings support the view that the pathological process is a distortion of the central nervous system myelination affecting the whole white matter. Our findings also show the effects of antipsychotics on the white matter in the left frontal region in schizophrenia. Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption of regional white matter in schizophrenia. Twelve patients with schizophrenia were compared with 11 healthy controls. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. A significant fractional anisotropy (FA) reduction was found in all white matter regions bilaterally in schizophrenic patients. Higher FA of left frontal white matter correlated significantly with higher dosage of antipsychotic medication. These findings support the view that the pathological process is a distortion of the central nervous system myelination affecting the whole white matter. Our findings also show the effects of antipsychotics on the white matter in the left frontal region in schizophrenia.Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption of regional white matter in schizophrenia. Twelve patients with schizophrenia were compared with 11 healthy controls. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. A significant fractional anisotropy (FA) reduction was found in all white matter regions bilaterally in schizophrenic patients. Higher FA of left frontal white matter correlated significantly with higher dosage of antipsychotic medication. These findings support the view that the pathological process is a distortion of the central nervous system myelination affecting the whole white matter. Our findings also show the effects of antipsychotics on the white matter in the left frontal region in schizophrenia. |
| Author | Kinoshita, T. Ikeda, K. Sawada, S. Okugawa, G. Yoshida, T. Minami, T. Nobuhara, K. Ha-Kawa, S. Takase, K. |
| Author_xml | – sequence: 1 givenname: T. surname: Minami fullname: Minami, T. – sequence: 2 givenname: K. surname: Nobuhara fullname: Nobuhara, K. – sequence: 3 givenname: G. surname: Okugawa fullname: Okugawa, G. – sequence: 4 givenname: K. surname: Takase fullname: Takase, K. – sequence: 5 givenname: T. surname: Yoshida fullname: Yoshida, T. – sequence: 6 givenname: S. surname: Sawada fullname: Sawada, S. – sequence: 7 givenname: S. surname: Ha-Kawa fullname: Ha-Kawa, S. – sequence: 8 givenname: K. surname: Ikeda fullname: Ikeda, K. – sequence: 9 givenname: T. surname: Kinoshita fullname: Kinoshita, T. |
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| Cites_doi | 10.1136/jnnp.68.2.242 10.1006/jmrb.1994.1037 10.1016/0168-0102(95)00917-I 10.1001/archpsyc.56.4.367 10.1016/S0006-3223(99)00018-9 10.1006/nimg.1999.0421 10.1073/pnas.081071198 10.1002/jmri.1076 10.1176/appi.ajp.159.5.813 10.1097/00001756-200107200-00041 10.1176/appi.ajp.159.2.227 10.1176/appi.ajp.159.2.244 10.1016/S0165-1781(01)00250-5 |
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| Keywords | Schizophrenia Anisotropy White matter Diffusion tensor imaging Psychosis Human Methodology Healthy subject Investigation method Magnetic resonance Central nervous system Positive and Negative Syndrome Scale Kay et al Comparative study Brain (vertebrata) |
| Language | English |
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| References | Beaulieu C, Allen PS: Determinants of anisotropic water diffusion in nerves. Magn Reson Med 1994;31:394-400.8208115 Werring DJ, Clark CA, Parker GJ, Miller DH, Thompson AJ, Barker GJ: A direct demonstration of both structure and function in the visual system: Combining diffusion tensor imaging with functional magnetic resonance imaging. Neuroimage 1999;9:352-361.1007590510.1006/nimg.1999.0421 Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO: Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: A preliminary study. Biol Psychiatry 2002;52:9-14. McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA, Shenton ME: MRI anatomy of schizophrenia. Biol Psychiatry 1999;45:1099-1119.1033110210.1016/S0006-3223(99)00018-9 Moseley ME, Cohen Y, Kucharczyk J, Mintorovitch J, Asgari HS, Wendland MF, Tsuruda J, Norman D: Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology 1990;176:439-445.2367658 Buchsbaum MS, Tang CY, Peled S, Gudbjartsson H, Lu D, Hazlett EA, Downhill J, Haznedar M, Fallon JH, Atlas SW: MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia. Neuroreport 1998;9:425-430.9512384 Deicken RF, Zhou L, Corwin F, Vinogradov S, Weiner MW: Decreased left frontal lobe N-acetylaspartate in schizophrenia. Am J Psychiatry 1997;154:688-690.9137129 Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, Haroutunian V, Fienberg AA: Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci USA 2001;98:4746-4751.1129630110.1073/pnas.081071198 Wible CG, Anderson J, Shenton ME, Kricun A, Hirayasu Y, Tanaka S, Levitt JJ, O'Donnell BF, Kikinis R, Jolesz FA, McCarley RW: Prefrontal cortex, negative symptoms, and schizophrenia: An MRI study. Psychiatry Res 2001;108:65-78.1173854110.1016/S0165-1781(01)00250-5 Jarema M, Choma M, Poniatowska R, Krawczyk R, Kozlowski P: Improvement criteria after neuroleptic treatment and clinical and neuroradiological factors in schizophrenic psychoses. Preliminary studies. Psychiatr Pol 1997;31:21-32.9527652 Kubicki M, Westin CF, Maier SE, Frumin M, Nestor PG, Salisbury DF, Kikinis R, Jolesz FA, McCarley RW, Shenton ME: Uncinate fasciculus findings in schizophrenia: A magnetic resonance diffusion tensor imaging study. Am J Psychiatry 2002;159:813-820.1198613610.1176/appi.ajp.159.5.813 Lim KO, Hedehus M, Moseley M, de Crespigny A, Sullivan EV, Pfefferbaum A: Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Arch Gen Psychiatry 1999;56:367-374.1019783410.1001/archpsyc.56.4.367 Hulshoff Pol HE, Schnack HG, Bertens MG, van Haren NE, van der Tweel I, Staal WG, Baare WF, Kahn RS: Volume changes in gray matter in patients with schizophrenia. Am J Psychiatry 2002;159:244-250.1182326610.1176/appi.ajp.159.2.244 Buchsbaum MS: The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophr Bull 1990;16:379-389.2287929 Potkin SG, Alva G, Fleming K, Anand R, Keator D, Carreon D, Doo M, Jin Y, Wu JC, Fallon JH: A PET study of the pathophysiology of negative symptoms in schizophrenia. Positron emission tomography. Am J Psychiatry 2002;159:227-237.1182326410.1176/appi.ajp.159.2.227 Agartz I, Andersson JL, Skare S: Abnormal brain white matter in schizophrenia: A diffusion tensor imaging study. Neuroreport 2001;12:2251-2254.1144734410.1097/00001756-200107200-00041 Basser PJ, Mattiello J, LeBihan D: Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994;103:247-254.801977610.1006/jmrb.1994.1037 Lawrie SM, Buechel C, Whalley HC, Frith CD, Friston KJ, Johnstone EC: Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 2002;51:1008-1011. Hirayasu Y, Potts GF, O'Donnell BF, Kwon JS, Arakaki H, Akdag SJ, Levitt JJ, Shenton ME, McCarley RW: Auditory mismatch negativity in schizophrenia: Topographic evaluation with a high-density recording montage. Am J Psychiatry 1998;155:1281-1284.9734556 Wimberger DM, Roberts TP, Barkovich AJ, Prayer LM, Moseley ME, Kucharczyk J: Identification of 'premyelination' by diffusion-weighted MRI. J Comput Assist Tomogr 1995;19:28-33.7529780 Nakada T, Matsuzawa H: Three-dimensional anisotropy contrast magnetic resonance imaging of the rat nervous system: MR axonography. Neurosci Res 1995;22:389-398.747830410.1016/0168-0102(95)00917-I Foong J, Maier M, Clark CA, Barker GJ, Miller DH, Ron MA: Neuropathological abnormalities of the corpus callosum in schizophrenia: A diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 2000;68:242-244.1064479910.1136/jnnp.68.2.242 Tauscher J, Fischer P, Neumeister A, Rappelsberger P, Kasper S: Low frontal electroencephalographic coherence in neuroleptic-free schizophrenic patients. Biol Psychiatry 1998;44:438-447. Makris N, Worth AJ, Sorensen AG, Papadimitriou GM, Wu O, Reese TG, Wedeen VJ, Davis TL, Stakes JW, Caviness VS, Kaplan E, Rosen BR, Pandya DN, Kennedy DN: Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging. Ann Neurol 1997;42:951-962.9403488 Paulus MP, Hozack NE, Zauscher BE, Frank L, Brown GG, McDowell J, Braff DL: Parietal dysfunction is associated with increased outcome-related decision-making in schizophrenia patients. Biol Psychiatry 2002;51:995-1004. Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H: Diffusion tensor imaging: Concepts and applications. J Magn Reson Imaging 2001;13:534-546.1127609710.1002/jmri.1076 ref13 ref12 ref11 ref10 ref2 ref1 ref8 ref7 ref9 ref4 ref3 ref6 ref5 |
| References_xml | – reference: Jarema M, Choma M, Poniatowska R, Krawczyk R, Kozlowski P: Improvement criteria after neuroleptic treatment and clinical and neuroradiological factors in schizophrenic psychoses. Preliminary studies. Psychiatr Pol 1997;31:21-32.9527652 – reference: McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA, Shenton ME: MRI anatomy of schizophrenia. Biol Psychiatry 1999;45:1099-1119.1033110210.1016/S0006-3223(99)00018-9 – reference: Paulus MP, Hozack NE, Zauscher BE, Frank L, Brown GG, McDowell J, Braff DL: Parietal dysfunction is associated with increased outcome-related decision-making in schizophrenia patients. Biol Psychiatry 2002;51:995-1004. – reference: Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO: Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: A preliminary study. Biol Psychiatry 2002;52:9-14. – reference: Lim KO, Hedehus M, Moseley M, de Crespigny A, Sullivan EV, Pfefferbaum A: Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Arch Gen Psychiatry 1999;56:367-374.1019783410.1001/archpsyc.56.4.367 – reference: Nakada T, Matsuzawa H: Three-dimensional anisotropy contrast magnetic resonance imaging of the rat nervous system: MR axonography. Neurosci Res 1995;22:389-398.747830410.1016/0168-0102(95)00917-I – reference: Beaulieu C, Allen PS: Determinants of anisotropic water diffusion in nerves. Magn Reson Med 1994;31:394-400.8208115 – reference: Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H: Diffusion tensor imaging: Concepts and applications. J Magn Reson Imaging 2001;13:534-546.1127609710.1002/jmri.1076 – reference: Tauscher J, Fischer P, Neumeister A, Rappelsberger P, Kasper S: Low frontal electroencephalographic coherence in neuroleptic-free schizophrenic patients. Biol Psychiatry 1998;44:438-447. – reference: Potkin SG, Alva G, Fleming K, Anand R, Keator D, Carreon D, Doo M, Jin Y, Wu JC, Fallon JH: A PET study of the pathophysiology of negative symptoms in schizophrenia. Positron emission tomography. Am J Psychiatry 2002;159:227-237.1182326410.1176/appi.ajp.159.2.227 – reference: Moseley ME, Cohen Y, Kucharczyk J, Mintorovitch J, Asgari HS, Wendland MF, Tsuruda J, Norman D: Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology 1990;176:439-445.2367658 – reference: Deicken RF, Zhou L, Corwin F, Vinogradov S, Weiner MW: Decreased left frontal lobe N-acetylaspartate in schizophrenia. Am J Psychiatry 1997;154:688-690.9137129 – reference: Werring DJ, Clark CA, Parker GJ, Miller DH, Thompson AJ, Barker GJ: A direct demonstration of both structure and function in the visual system: Combining diffusion tensor imaging with functional magnetic resonance imaging. Neuroimage 1999;9:352-361.1007590510.1006/nimg.1999.0421 – reference: Agartz I, Andersson JL, Skare S: Abnormal brain white matter in schizophrenia: A diffusion tensor imaging study. Neuroreport 2001;12:2251-2254.1144734410.1097/00001756-200107200-00041 – reference: Makris N, Worth AJ, Sorensen AG, Papadimitriou GM, Wu O, Reese TG, Wedeen VJ, Davis TL, Stakes JW, Caviness VS, Kaplan E, Rosen BR, Pandya DN, Kennedy DN: Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging. Ann Neurol 1997;42:951-962.9403488 – reference: Kubicki M, Westin CF, Maier SE, Frumin M, Nestor PG, Salisbury DF, Kikinis R, Jolesz FA, McCarley RW, Shenton ME: Uncinate fasciculus findings in schizophrenia: A magnetic resonance diffusion tensor imaging study. Am J Psychiatry 2002;159:813-820.1198613610.1176/appi.ajp.159.5.813 – reference: Lawrie SM, Buechel C, Whalley HC, Frith CD, Friston KJ, Johnstone EC: Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 2002;51:1008-1011. – reference: Wimberger DM, Roberts TP, Barkovich AJ, Prayer LM, Moseley ME, Kucharczyk J: Identification of 'premyelination' by diffusion-weighted MRI. J Comput Assist Tomogr 1995;19:28-33.7529780 – reference: Buchsbaum MS, Tang CY, Peled S, Gudbjartsson H, Lu D, Hazlett EA, Downhill J, Haznedar M, Fallon JH, Atlas SW: MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia. Neuroreport 1998;9:425-430.9512384 – reference: Hirayasu Y, Potts GF, O'Donnell BF, Kwon JS, Arakaki H, Akdag SJ, Levitt JJ, Shenton ME, McCarley RW: Auditory mismatch negativity in schizophrenia: Topographic evaluation with a high-density recording montage. Am J Psychiatry 1998;155:1281-1284.9734556 – reference: Hulshoff Pol HE, Schnack HG, Bertens MG, van Haren NE, van der Tweel I, Staal WG, Baare WF, Kahn RS: Volume changes in gray matter in patients with schizophrenia. Am J Psychiatry 2002;159:244-250.1182326610.1176/appi.ajp.159.2.244 – reference: Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, Haroutunian V, Fienberg AA: Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci USA 2001;98:4746-4751.1129630110.1073/pnas.081071198 – reference: Wible CG, Anderson J, Shenton ME, Kricun A, Hirayasu Y, Tanaka S, Levitt JJ, O'Donnell BF, Kikinis R, Jolesz FA, McCarley RW: Prefrontal cortex, negative symptoms, and schizophrenia: An MRI study. Psychiatry Res 2001;108:65-78.1173854110.1016/S0165-1781(01)00250-5 – reference: Foong J, Maier M, Clark CA, Barker GJ, Miller DH, Ron MA: Neuropathological abnormalities of the corpus callosum in schizophrenia: A diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 2000;68:242-244.1064479910.1136/jnnp.68.2.242 – reference: Basser PJ, Mattiello J, LeBihan D: Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994;103:247-254.801977610.1006/jmrb.1994.1037 – reference: Buchsbaum MS: The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophr Bull 1990;16:379-389.2287929 – ident: ref10 doi: 10.1136/jnnp.68.2.242 – ident: ref3 doi: 10.1006/jmrb.1994.1037 – ident: ref2 doi: 10.1016/0168-0102(95)00917-I – ident: ref9 doi: 10.1001/archpsyc.56.4.367 – ident: ref5 doi: 10.1016/S0006-3223(99)00018-9 – ident: ref4 doi: 10.1006/nimg.1999.0421 – ident: ref13 doi: 10.1073/pnas.081071198 – ident: ref1 doi: 10.1002/jmri.1076 – ident: ref11 doi: 10.1176/appi.ajp.159.5.813 – ident: ref12 doi: 10.1097/00001756-200107200-00041 – ident: ref8 doi: 10.1176/appi.ajp.159.2.227 – ident: ref7 doi: 10.1176/appi.ajp.159.2.244 – ident: ref6 doi: 10.1016/S0165-1781(01)00250-5 |
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| Snippet | Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Anisotropy Biological and medical sciences Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper Brain - anatomy & histology Diffusion Magnetic Resonance Imaging Female Humans Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - diagnosis Schizophrenia Schizophrenia - diagnosis Severity of Illness Index Surveys and Questionnaires |
| Title | Diffusion Tensor Magnetic Resonance Imaging of Disruption of Regional White Matter in Schizophrenia |
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