Ligand Cross-reactivity within the Protease-activated Receptor Family

• Published in: The Journal of biological chemistry Vol. 271; no. 28; pp. 16466 - 16471
• Main Authors: Blackhart, Brian D., Emilsson, Kjell, Nguyen, Dat, Teng, Willy, Martelli, Arnold J., Nystedt, Sverker, Sundelin, Johan, Scarborough, Robert M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.07.1996; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Animals; Humans; Ligands; Mice; Molecular Sequence Data; Oligopeptides - pharmacology; Peptide Fragments - pharmacology; Receptor, PAR-2; Receptors, Cell Surface - agonists; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Trypsin - pharmacology; Xenopus laevis

Recently, a second member of the protease-activated receptor (PAR) family, named PAR-2, has been identified. Similar to the thrombin receptor, PAR-2 appears to be activated by proteolytic-mediated exposure of a “tethered ligand” sequence and can also be activated by the corresponding synthetic pepti...