Systemic Treatment with Nicotinamide Riboside Is Protective in Two Mouse Models of Retinal Ganglion Cell Damage

• Published in: Pharmaceutics Vol. 13; no. 6; p. 893
• Main Authors: Zhang, Xian, Zhang, Nan, Chrenek, Micah A., Girardot, Preston E., Wang, Jiaxing, Sellers, Jana T., Geisert, Eldon E., Brenner, Charles, Nickerson, John M., Boatright, Jeffrey H., Li, Ying
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 16.06.2021; MDPI
• Subjects: Age; Animals; Antibiotics; Drug dosages; ERG; Experiments; Gene expression; Glaucoma; Metabolism; microbead; neuroprotection; nicotinamide riboside; Optic nerve; optic nerve crush; retinal ganglion cell; United States > US

Glaucoma etiology often includes retinal ganglion cell (RGC) death associated with elevated intraocular pressure (IOP). However, even when IOP is managed well, disease can progress. It is thus important to develop therapeutic approaches that directly protect RGCs in an IOP-independent manner. Compro...