Effect of JTC-801 (nociceptin antagonist) on neuropathic pain in a rat model

JTC-801, a nociceptin antagonist, may alleviate neuropathic pain because nociceptin has been shown to produce pain modulation. We report that JTC-801 alleviates heat-evoked hyperalgesia and investigated the possible protective effect on osteoporosis induced by chronic constriction injury (CCI) in ra...

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Bibliographic Details
Published inNeuroscience letters Vol. 351; no. 3; pp. 133 - 136
Main Authors Suyama, Hidemichi, Kawamoto, Masashi, Gaus, Syafruddin, Yuge, Osafumi
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 20.11.2003
Elsevier
Subjects
Aminoquinolines - administration & dosage
Animals
Benzamides - administration & dosage
Biological and medical sciences
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Disease Models, Animal
Hyperalgesia - drug therapy
Hyperalgesia - pathology
JTC-801
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropathic osteoporosis
Neuropathic pain
Nociceptin
Nociceptin antagonist
Opioid Peptides - antagonists & inhibitors
Pain Measurement - drug effects
Rat
Rats
Rats, Sprague-Dawley
Neuropathic osteoporosis
Nociceptin antagonist
Rat
JTC-801
Neuropathic pain
Animal model
Nervous system diseases
Rodentia
Peripheral neuropathy
Nociceptin
Osteoporosis
Vertebrata
Mammalia
Pain
Antagonist
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Summary:JTC-801, a nociceptin antagonist, may alleviate neuropathic pain because nociceptin has been shown to produce pain modulation. We report that JTC-801 alleviates heat-evoked hyperalgesia and investigated the possible protective effect on osteoporosis induced by chronic constriction injury (CCI) in rats. JTC-801 was given orally to rats with CCI at 0% (vehicle), 0.03% (low dose), or 0.06% (high dose) in food. Paw withdrawal latency (PWL) to heat, bone mineral content (BMC) and bone mineral density (BMD) of the whole tibial bone were measured. JTC-801 dose-dependently normalized PWL. Although JTC-801 did not inhibit a CCI-induced decrease in BMC and BMD, it inhibited an increase in the number of osteoclasts in the JTC-801 groups. JTC-801, given orally in food, alleviated heat-evoked hyperalgesia in CCI rats, suggesting that it is useful for the treatment of neuropathic pain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(03)00502-0