Synthesis, Characterization, and Bioactivity of Mesoporous Bioactive Glass Codoped with Zinc and Silver

Due to the overconsumption of antimicrobials, antibiotic-resistant bacteria have become a critical health issue worldwide, especially methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE). Recently, many efforts have been made to load metals into bioactive glasses to enha...

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Published inInternational journal of molecular sciences Vol. 24; no. 18; p. 13679
Main Authors Yang, Tsung-Ying, Chern, Guann-In, Wang, Wei-Hsun, Shih, Chi-Jen
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2023
MDPI
Subjects
Alkalinity
antibacterial
Antibiotics
Bacterial infections
Biological activity
Biological products
biomaterial
Drug resistance
Drug resistance in microorganisms
drug-resistant bacteria
E coli
Health aspects
Hydroxyapatite
Methicillin
Nanoparticles
osteoinduction
Silver
Staphylococcus aureus
Staphylococcus infections
Zinc
Japan
Taiwan
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Abstract Due to the overconsumption of antimicrobials, antibiotic-resistant bacteria have become a critical health issue worldwide, especially methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE). Recently, many efforts have been made to load metals into bioactive glasses to enhance the multifunctionality of materials, such as antibacterial and osteoinductive functions. Zinc has been documented to stimulate the gene expression of various regulatory factors in bone cells. Meanwhile, previous studies have reported that silver and zinc could be a promising antibacterial combination with synergistic antimicrobial effects. Here, we sought to develop a biomaterial coreleasing zinc and silver, designated 80S-ZnAg, and to evaluate its antibacterial activity and biocompatibility. The textural analyses demonstrated different coreleasing patterns of zinc and silver for the materials. The chemical characterization revealed that the zinc in 80S-ZnAg could be the network modifier when its molar ratio was high, releasing more zinc; zinc could also be the network former when its molar ratio was low, showing an extremely low rate of release. However, the ICP results for 80S-Zn3Ag2 demonstrated up to 7.5 ppm of zinc and 67.6 ppm of silver. Among all the 80S-ZnAg materials, 80S-Zn3Ag2 demonstrated more marked antibacterial activity against MRSA and VRE than the others, with inhibition zones of 11.5 and 13.4 mm, respectively. The cytotoxicity assay exhibited nearly 90% cell viability at 20 mg/mL of 80-Zn3Ag2. Further clinical study is needed to develop an innovative biomaterial to address the issue of antibiotic resistance.
AbstractList Due to the overconsumption of antimicrobials, antibiotic-resistant bacteria have become a critical health issue worldwide, especially methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE). Recently, many efforts have been made to load metals into bioactive glasses to enhance the multifunctionality of materials, such as antibacterial and osteoinductive functions. Zinc has been documented to stimulate the gene expression of various regulatory factors in bone cells. Meanwhile, previous studies have reported that silver and zinc could be a promising antibacterial combination with synergistic antimicrobial effects. Here, we sought to develop a biomaterial coreleasing zinc and silver, designated 80S-ZnAg, and to evaluate its antibacterial activity and biocompatibility. The textural analyses demonstrated different coreleasing patterns of zinc and silver for the materials. The chemical characterization revealed that the zinc in 80S-ZnAg could be the network modifier when its molar ratio was high, releasing more zinc; zinc could also be the network former when its molar ratio was low, showing an extremely low rate of release. However, the ICP results for 80S-Zn3Ag2 demonstrated up to 7.5 ppm of zinc and 67.6 ppm of silver. Among all the 80S-ZnAg materials, 80S-Zn3Ag2 demonstrated more marked antibacterial activity against MRSA and VRE than the others, with inhibition zones of 11.5 and 13.4 mm, respectively. The cytotoxicity assay exhibited nearly 90% cell viability at 20 mg/mL of 80-Zn3Ag2. Further clinical study is needed to develop an innovative biomaterial to address the issue of antibiotic resistance.
Due to the overconsumption of antimicrobials, antibiotic-resistant bacteria have become a critical health issue worldwide, especially methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE). Recently, many efforts have been made to load metals into bioactive glasses to enhance the multifunctionality of materials, such as antibacterial and osteoinductive functions. Zinc has been documented to stimulate the gene expression of various regulatory factors in bone cells. Meanwhile, previous studies have reported that silver and zinc could be a promising antibacterial combination with synergistic antimicrobial effects. Here, we sought to develop a biomaterial coreleasing zinc and silver, designated 80S-ZnAg, and to evaluate its antibacterial activity and biocompatibility. The textural analyses demonstrated different coreleasing patterns of zinc and silver for the materials. The chemical characterization revealed that the zinc in 80S-ZnAg could be the network modifier when its molar ratio was high, releasing more zinc; zinc could also be the network former when its molar ratio was low, showing an extremely low rate of release. However, the ICP results for 80S-Zn3Ag2 demonstrated up to 7.5 ppm of zinc and 67.6 ppm of silver. Among all the 80S-ZnAg materials, 80S-Zn3Ag2 demonstrated more marked antibacterial activity against MRSA and VRE than the others, with inhibition zones of 11.5 and 13.4 mm, respectively. The cytotoxicity assay exhibited nearly 90% cell viability at 20 mg/mL of 80-Zn3Ag2. Further clinical study is needed to develop an innovative biomaterial to address the issue of antibiotic resistance.
Audience Academic
Author Shih, Chi-Jen
Yang, Tsung-Ying
Wang, Wei-Hsun
Chern, Guann-In
AuthorAffiliation 3 Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan
9 Department of Chemical Engineering, National United University, Miaoli 36063, Taiwan
12 Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
13 Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
2 Research Organization for Nano and Life Innovation, Future Innovation Institute, Waseda University, Tokyo 162-0041, Japan
10 Department of Golden-Ager Industry Management, Chaoyang University of Technology, Taichung 41349, Taiwan
11 Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine and Management, Kaohsiung 82144, Taiwan
7 Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 40227, Taiwan
1 Department of Medical Laboratory Science, I-Shou University, Kaohsiung 84001, Taiwan; zegma040899@gmail.com
4 School of Education, Waseda Univer
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Cites_doi 10.1111/j.1365-2591.2011.01886.x
10.1016/j.actbio.2008.04.007
10.1038/s41598-017-01017-7
10.1007/s10565-007-9040-z
10.1097/00004770-200405000-00004
10.4103/jispcd.JISPCD_29_18
10.1016/j.ceramint.2017.10.208
10.1016/j.jnoncrysol.2020.120568
10.1016/j.msec.2019.109910
10.1016/j.freeradbiomed.2004.07.007
10.1016/j.ceramint.2014.06.105
10.1016/j.actbio.2019.07.012
10.4162/nrp.2007.1.2.113
10.1016/j.jallcom.2020.156487
10.1007/s11837-020-04006-w
10.1039/C5RA17024A
10.3390/ijms22137202
10.1016/S0140-6736(04)16727-5
10.1016/j.jnoncrysol.2023.122371
10.1111/j.1574-6968.2007.01012.x
10.1016/j.matchemphys.2018.07.038
10.1006/bbrc.2000.3503
10.1016/j.msec.2015.03.057
10.3390/nano8080592
10.1016/j.jnoncrysol.2020.120492
10.1016/j.ceramint.2015.10.090
10.1007/s40820-015-0040-x
10.1002/1097-4636(20010315)54:4<560::AID-JBM130>3.0.CO;2-J
10.2147/IJN.S246764
10.2320/matertrans.45.1147
10.1016/j.msec.2019.110180
10.1016/j.matlet.2016.01.156
10.3390/biomimetics5040057
10.20944/preprints201705.0176.v1
10.3390/nano9091265
10.1016/j.ceramint.2017.07.100
10.1016/j.ceramint.2020.08.149
10.1007/s11010-009-0358-0
10.1086/533590
10.1002/anie.200460598
10.1016/j.msec.2021.112093
10.1177/0022034509357148
10.1016/j.apsusc.2008.06.101
10.1038/s41598-023-34042-w
10.1016/j.tsf.2007.11.081
10.1016/j.pcrysgrow.2014.09.005
10.1039/D0TB02884C
10.1056/NEJM199808203390806
10.1016/j.scriptamat.2014.01.033
10.1016/j.ceramint.2011.04.025
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References Akhtach (ref_28) 2021; 47
Koohkan (ref_56) 2018; 44
Xynos (ref_16) 2000; 276
Chiang (ref_13) 2010; 89
Zhang (ref_12) 2008; 4
Boucher (ref_5) 2008; 46
Naruphontjirakul (ref_31) 2023; 13
Chen (ref_45) 2020; 848
Yamaguchi (ref_30) 2010; 338
Goh (ref_46) 2014; 78
Lowy (ref_4) 1998; 339
Bai (ref_19) 2021; 9
McGuinness (ref_6) 2017; 90
Hamadouche (ref_17) 2001; 54
Shruti (ref_42) 2014; 2
Lalzawmliana (ref_21) 2020; 106
ref_20
Santos (ref_44) 2014; 386
Chen (ref_41) 2020; 72
Jones (ref_52) 2008; 279
(ref_22) 2015; 1
Siqueira (ref_7) 2004; 30
Azizabadi (ref_39) 2021; 556
Cho (ref_29) 2007; 1
Calahoo (ref_49) 2020; 8
Fujino (ref_55) 2004; 45
Yin (ref_35) 2020; 15
Castillo (ref_37) 2017; 7
Wang (ref_47) 2015; 5
Kanumuru (ref_8) 2014; 8
Prasad (ref_32) 2004; 37
ref_34
Sirelkhatim (ref_53) 2015; 7
Capela (ref_26) 2017; 43
ref_33
Bhatia (ref_58) 2008; 24
Chen (ref_50) 2021; 553
Shih (ref_43) 2014; 40
Chen (ref_15) 2008; 255
Atkinson (ref_25) 2016; 42
Yuan (ref_54) 2018; 218
ref_38
Zhu (ref_23) 2016; 171
Mohammadi (ref_9) 2011; 44
Kaur (ref_10) 2017; 11
Lew (ref_2) 2004; 364
Yan (ref_18) 2004; 43
Sergi (ref_27) 2019; 104
Wu (ref_24) 2015; 52
Dalmia (ref_11) 2018; 8
Shook (ref_3) 2019; 96
Shahrabi (ref_40) 2011; 37
Yang (ref_57) 2021; 125
ref_48
Rey (ref_14) 2014; 60
Tam (ref_51) 2008; 516
Li (ref_36) 2023; 613
Michno (ref_1) 2018; 92
References_xml – volume: 44
  start-page: 697
  year: 2011
  ident: ref_9
  article-title: Properties and applications of calcium hydroxide in endodontics and dental traumatology
  publication-title: Int. Endod. J.
  doi: 10.1111/j.1365-2591.2011.01886.x
  contributor:
    fullname: Mohammadi
– volume: 4
  start-page: 149820081505
  year: 2008
  ident: ref_12
  article-title: In situ pH within particle beds of bioactive glasses
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2008.04.007
  contributor:
    fullname: Zhang
– volume: 7
  start-page: 903
  year: 2017
  ident: ref_37
  article-title: Synergistic antimicrobial effects of silver/transition-metal combinatorial treatments
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-01017-7
  contributor:
    fullname: Castillo
– volume: 24
  start-page: 315
  year: 2008
  ident: ref_58
  article-title: Correlation of visual in vitro cytotoxicity ratings of biomaterials with quantitative in vitro cell viability measurements
  publication-title: Cell Biol. Toxicol.
  doi: 10.1007/s10565-007-9040-z
  contributor:
    fullname: Bhatia
– volume: 30
  start-page: 315
  year: 2004
  ident: ref_7
  article-title: Association of Enterococcus faecalis with different forms of periradicular diseases
  publication-title: J. Endod.
  doi: 10.1097/00004770-200405000-00004
  contributor:
    fullname: Siqueira
– volume: 8
  start-page: 104
  year: 2018
  ident: ref_11
  article-title: Antimicrobial efficacy of different endodontic sealers against Enterococcus faecalis: An in vitro study
  publication-title: J. Int. Soc. Prev. Community Dent.
  doi: 10.4103/jispcd.JISPCD_29_18
  contributor:
    fullname: Dalmia
– volume: 1
  start-page: 140
  year: 2015
  ident: ref_22
  article-title: Mesoporous bioactive glasses: Relevance of their porous structure compared to that of classical bioglasses
  publication-title: Biomed. Glas.
– volume: 44
  start-page: 2390
  year: 2018
  ident: ref_56
  article-title: Synthesis, characterization and in vitro bioactivity of mesoporous copper silicate bioactive glasses
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2017.10.208
  contributor:
    fullname: Koohkan
– volume: 556
  start-page: 120568
  year: 2021
  ident: ref_39
  article-title: Synthesis and characteristics of gel-derived SiO2-CaO-P2O5-SrO-Ag2O-ZnO bioactive glass: Bioactivity, biocompatibility, and antibacterial properties
  publication-title: J. Non-Cryst. Solids
  doi: 10.1016/j.jnoncrysol.2020.120568
  contributor:
    fullname: Azizabadi
– volume: 104
  start-page: 109910
  year: 2019
  ident: ref_27
  article-title: Zinc containing bioactive glasses with ultra-high crystallization temperature, good biological performance and antibacterial effects
  publication-title: Mater. Sci. Eng. C Mater. Biol. Appl.
  doi: 10.1016/j.msec.2019.109910
  contributor:
    fullname: Sergi
– volume: 37
  start-page: 1182
  year: 2004
  ident: ref_32
  article-title: Antioxidant effect of zinc in humans
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2004.07.007
  contributor:
    fullname: Prasad
– volume: 40
  start-page: 15019
  year: 2014
  ident: ref_43
  article-title: Evaluation of gentamicin encapsulated hierarchically meso-macroporous silica-based calcium phosphates glass powders
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2014.06.105
  contributor:
    fullname: Shih
– volume: 96
  start-page: 537
  year: 2019
  ident: ref_3
  article-title: Resurrection of antibiotics that methicillin-resistant Staphylococcus aureus resists by silver-doped bioactive glass-ceramic microparticles
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2019.07.012
  contributor:
    fullname: Shook
– volume: 92
  start-page: 272
  year: 2018
  ident: ref_1
  article-title: Review of contemporary knowledge of osteomyelitis diagnosis
  publication-title: World Sci. News
  contributor:
    fullname: Michno
– volume: 1
  start-page: 113
  year: 2007
  ident: ref_29
  article-title: Zinc deficiency negatively affects alkaline phosphatase and the concentration of Ca, Mg and P in rats
  publication-title: Nutr. Res. Pract.
  doi: 10.4162/nrp.2007.1.2.113
  contributor:
    fullname: Cho
– volume: 848
  start-page: 156487
  year: 2020
  ident: ref_45
  article-title: Compounds, Structure-dependence of anti-methicillin-resistant Staphylococcus aureus (MRSA) activity on ZnO-containing bioglass
  publication-title: J. Alloys Compd.
  doi: 10.1016/j.jallcom.2020.156487
  contributor:
    fullname: Chen
– volume: 72
  start-page: 1414
  year: 2020
  ident: ref_41
  article-title: Effect of B2O3 on structure of glassy F-free CaO-SiO2-B2O3 systems by 29Si MAS NMR and Raman spectroscopy
  publication-title: JOM
  doi: 10.1007/s11837-020-04006-w
  contributor:
    fullname: Chen
– volume: 2
  start-page: 4836
  year: 2014
  ident: ref_42
  article-title: In vitro antibacterial capacity and cytocompatibility of SiO2–CaO–P2O5 meso-macroporous glass scaffolds enriched with ZnO
  publication-title: J. Mater. Chem.
  contributor:
    fullname: Shruti
– volume: 5
  start-page: 87496
  year: 2015
  ident: ref_47
  article-title: Electronic structure and optical properties of Zn(OH)2: LDA+ U calculations and intense yellow luminescence
  publication-title: RSC Adv.
  doi: 10.1039/C5RA17024A
  contributor:
    fullname: Wang
– ident: ref_34
  doi: 10.3390/ijms22137202
– volume: 364
  start-page: 369
  year: 2004
  ident: ref_2
  article-title: Osteomyelitis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(04)16727-5
  contributor:
    fullname: Lew
– volume: 613
  start-page: 122371
  year: 2023
  ident: ref_36
  article-title: Evaluation of in vitro bioactivity and angiogenesis-promoting effect for mesoporous bioactive glass codoped with copper and silver
  publication-title: J. Non-Cryst. Solids
  doi: 10.1016/j.jnoncrysol.2023.122371
  contributor:
    fullname: Li
– volume: 279
  start-page: 71
  year: 2008
  ident: ref_52
  article-title: Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms
  publication-title: FEMS Microbiol. Lett.
  doi: 10.1111/j.1574-6968.2007.01012.x
  contributor:
    fullname: Jones
– volume: 218
  start-page: 130
  year: 2018
  ident: ref_54
  article-title: Bioactive silver doped hydroxyapatite composite coatings on metal substrates: Synthesis and characterization
  publication-title: Mater. Chem. Phys.
  doi: 10.1016/j.matchemphys.2018.07.038
  contributor:
    fullname: Yuan
– volume: 276
  start-page: 461
  year: 2000
  ident: ref_16
  article-title: Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.2000.3503
  contributor:
    fullname: Xynos
– volume: 52
  start-page: 242
  year: 2015
  ident: ref_24
  article-title: Zn and Sr incorporated 64S bioglasses: Material characterization, in-vitro bioactivity and mesenchymal stem cell responses
  publication-title: Mater. Sci. Eng. C Mater. Biol. Appl.
  doi: 10.1016/j.msec.2015.03.057
  contributor:
    fullname: Wu
– volume: 8
  start-page: ZC135
  year: 2014
  ident: ref_8
  article-title: Bacterial efficacy of Ca(OH)2 against E. faecalis compared with three dental lasers on root canal dentin- an in vitro study
  publication-title: J. Clin. Diagn. Res.
  contributor:
    fullname: Kanumuru
– ident: ref_20
  doi: 10.3390/nano8080592
– volume: 553
  start-page: 120492
  year: 2021
  ident: ref_50
  article-title: Effects of AgNPs on the structure and anti-methicillin resistant Staphylococcus aureus (MRSA) properties of SiO2-CaO-P2O5 bioactive glass
  publication-title: J. Non-Cryst. Solids
  doi: 10.1016/j.jnoncrysol.2020.120492
  contributor:
    fullname: Chen
– volume: 42
  start-page: 3033
  year: 2016
  ident: ref_25
  article-title: Influence of ZnO addition on the structural, in vitro behavior and antimicrobial activity of sol–gel derived CaO–P2O5–SiO2 bioactive glasses
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2015.10.090
  contributor:
    fullname: Atkinson
– volume: 7
  start-page: 219
  year: 2015
  ident: ref_53
  article-title: Review on zinc oxide nanoparticles: Antibacterial activity and toxicity mechanism
  publication-title: Nano-Micro Lett.
  doi: 10.1007/s40820-015-0040-x
  contributor:
    fullname: Sirelkhatim
– volume: 54
  start-page: 560
  year: 2001
  ident: ref_17
  article-title: Long-term in vivo bioactivity and degradability of bulk sol-gel bioactive glasses
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/1097-4636(20010315)54:4<560::AID-JBM130>3.0.CO;2-J
  contributor:
    fullname: Hamadouche
– volume: 15
  start-page: 2555
  year: 2020
  ident: ref_35
  article-title: The antibacterial mechanism of silver nanoparticles and its application in dentistry
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S246764
  contributor:
    fullname: Yin
– volume: 45
  start-page: 1147
  year: 2004
  ident: ref_55
  article-title: Fabrication and characterization of bioactive glass coatings on Co-Cr implant alloys
  publication-title: Mater. Trans.
  doi: 10.2320/matertrans.45.1147
  contributor:
    fullname: Fujino
– volume: 106
  start-page: 110180
  year: 2020
  ident: ref_21
  article-title: Mesoporous bioactive glasses for bone healing and biomolecules delivery
  publication-title: Mater. Sci. Eng.
  doi: 10.1016/j.msec.2019.110180
  contributor:
    fullname: Lalzawmliana
– volume: 171
  start-page: 259
  year: 2016
  ident: ref_23
  article-title: Synthesis of monodispersed mesoporous bioactive glass nanospheres for bone repair
  publication-title: Mater. Lett.
  doi: 10.1016/j.matlet.2016.01.156
  contributor:
    fullname: Zhu
– ident: ref_48
  doi: 10.3390/biomimetics5040057
– volume: 386
  start-page: 19
  year: 2014
  ident: ref_44
  article-title: Individual and combined effects of the elements Zn, Mg and Sr on the surface reactivity of a SiO2·CaO·Na2O·P2O5
  publication-title: Bioglass Syst.
  contributor:
    fullname: Santos
– ident: ref_33
  doi: 10.20944/preprints201705.0176.v1
– volume: 8
  start-page: 100054
  year: 2020
  ident: ref_49
  article-title: Ionic glasses: Structure, properties and classification
  publication-title: J. Non-Cryst. Solids X
  contributor:
    fullname: Calahoo
– ident: ref_38
  doi: 10.3390/nano9091265
– volume: 43
  start-page: 13800
  year: 2017
  ident: ref_26
  article-title: Bioactivity and antibacterial activity against E. coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2017.07.100
  contributor:
    fullname: Capela
– volume: 47
  start-page: 424
  year: 2021
  ident: ref_28
  article-title: A comprehensive study on copper incorporated bio-glass matrix for its potential antimicrobial applications
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2020.08.149
  contributor:
    fullname: Akhtach
– volume: 338
  start-page: 241
  year: 2010
  ident: ref_30
  article-title: Role of nutritional zinc in the prevention of osteoporosis
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-009-0358-0
  contributor:
    fullname: Yamaguchi
– volume: 46
  start-page: S344
  year: 2008
  ident: ref_5
  article-title: Epidemiology of methicillin-resistant Staphylococcus aureus
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/533590
  contributor:
    fullname: Boucher
– volume: 90
  start-page: 269
  year: 2017
  ident: ref_6
  article-title: Medicine, Focus: Infectious diseases: Vancomycin resistance in Staphylococcus aureus
  publication-title: Yale J. Biol. Med.
  contributor:
    fullname: McGuinness
– volume: 43
  start-page: 5980
  year: 2004
  ident: ref_18
  article-title: Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.200460598
  contributor:
    fullname: Yan
– volume: 125
  start-page: 112093
  year: 2021
  ident: ref_57
  article-title: In vitro and in vivo assessments of inspired Ag/80S bioactive nanocomposites against carbapenem-resistant Klebsiella pneumoniae
  publication-title: Mater. Sci. Eng. C Mater. Biol. Appl.
  doi: 10.1016/j.msec.2021.112093
  contributor:
    fullname: Yang
– volume: 11
  start-page: ZG01
  year: 2017
  ident: ref_10
  article-title: MTA versus Biodentine: Review of literature with a comparative analysis
  publication-title: J. Clin. Diagn. Res.
  contributor:
    fullname: Kaur
– volume: 89
  start-page: 236
  year: 2010
  ident: ref_13
  article-title: A novel mesoporous biomaterial for treating dentin hypersensitivity
  publication-title: J. Dent. Res.
  doi: 10.1177/0022034509357148
  contributor:
    fullname: Chiang
– volume: 255
  start-page: 562
  year: 2008
  ident: ref_15
  article-title: Investigation on bio-mineralization of melt and sol–gel derived bioactive glasses
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2008.06.101
  contributor:
    fullname: Chen
– volume: 13
  start-page: 6775
  year: 2023
  ident: ref_31
  article-title: Multifunctional Zn and Ag co-doped bioactive glass nanoparticles for bone therapeutic and regeneration
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-023-34042-w
  contributor:
    fullname: Naruphontjirakul
– volume: 516
  start-page: 6167
  year: 2008
  ident: ref_51
  article-title: Antibacterial activity of ZnO nanorods prepared by a hydrothermal method
  publication-title: Thin Solid Film.
  doi: 10.1016/j.tsf.2007.11.081
  contributor:
    fullname: Tam
– volume: 60
  start-page: 63
  year: 2014
  ident: ref_14
  article-title: Surface properties of biomimetic nanocrystalline apatites: Applications in biomaterials
  publication-title: Prog. Cryst. Growth Charact. Mater.
  doi: 10.1016/j.pcrysgrow.2014.09.005
  contributor:
    fullname: Rey
– volume: 9
  start-page: 2885
  year: 2021
  ident: ref_19
  article-title: Sequential macrophage transition facilitates endogenous bone regeneration induced by Zn-doped porous microcrystalline bioactive glass
  publication-title: J. Mater. Chem. B
  doi: 10.1039/D0TB02884C
  contributor:
    fullname: Bai
– volume: 339
  start-page: 520
  year: 1998
  ident: ref_4
  article-title: Staphylococcus aureus infections
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199808203390806
  contributor:
    fullname: Lowy
– volume: 78
  start-page: 49
  year: 2014
  ident: ref_46
  article-title: Effect of particle size on the UV absorbance of zinc oxide nanoparticles
  publication-title: Scr. Mater.
  doi: 10.1016/j.scriptamat.2014.01.033
  contributor:
    fullname: Goh
– volume: 37
  start-page: 2737
  year: 2011
  ident: ref_40
  article-title: Structural discrepancies and in vitro nanoapatite formation ability of sol–gel derived glasses doped with different bone stimulator ions
  publication-title: Ceram. Int.
  doi: 10.1016/j.ceramint.2011.04.025
  contributor:
    fullname: Shahrabi
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Snippet Due to the overconsumption of antimicrobials, antibiotic-resistant bacteria have become a critical health issue worldwide, especially methicillin-resistant S....
Due to the overconsumption of antimicrobials, antibiotic-resistant bacteria have become a critical health issue worldwide, especially methicillin-resistant S....
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SubjectTerms Alkalinity
antibacterial
Antibiotics
Bacterial infections
Biological activity
Biological products
biomaterial
Drug resistance
Drug resistance in microorganisms
drug-resistant bacteria
E coli
Health aspects
Hydroxyapatite
Methicillin
Nanoparticles
osteoinduction
Silver
Staphylococcus aureus
Staphylococcus infections
Zinc
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Title Synthesis, Characterization, and Bioactivity of Mesoporous Bioactive Glass Codoped with Zinc and Silver
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https://search.proquest.com/docview/2870139265
https://pubmed.ncbi.nlm.nih.gov/PMC10531463
https://doaj.org/article/2f9291cdd6cc4c449d93adf4f42be871
Volume 24
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