Characterizing nanoscale changes in the activity of VEGFR-2 on glioma microvascular endothelial cell membranes using atomic force microscopy

• Published in: Experimental and therapeutic medicine Vol. 13; no. 2; pp. 483 - 488
• Main Authors: Zhou, Dexiang, Zhan, Shengquan, Zhou, Dong, Wang, Peng, Chen, Guangzhong, Qin, Kun, Lin, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.02.2017; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Angiogenesis; Antigens; Brain cancer; Care and treatment; Cell membranes; Diagnosis; Dosage and administration; Endothelium; Glioma; Gliomas; Health aspects; Inhibitor drugs; Kinases; Lung cancer; Membranes; Microscopy; Penicillin; Proteins; Studies; Tumors; Vascular endothelial growth factor; China; Beijing China; United States > US; Japan; bradykinin; glioma; vascular endothelial growth factor receptor-2; sorafenib; atomic force microscopy; endothelial cell

The aim of the current study was to demonstrate the distribution of VEGFR-2 on glioma microvascular endothelial cells on a nanoscale and investigate changes in VEGFR-2 activity following treatment with the VEGFR-2 inhibitor and agonist sorafenib and bradykinin, respectively. Three groups were evalua...