An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3 - Kizuka, Yasuhiko; Nakano, Miyako; Yamaguchi, Yoshiki; Nakajima, Kazuki; Oka, Ritsuko; Sato, Keiko; Ren, Chien-Tai; Hsu, Tsui-Ling; Wong, Chi-Huey; Taniguchi, Naoyuki (Cell chemical biology, 2017)
Keywords: Alkynes - chemistry; Alkynes - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Carbohydrate Epimerases - antagonists & inhibitors; Carbohydrate Epimerases - metabolism; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Movement - drug effects; Drug Screening Assays, Antitumor; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; fucose; Fucose - chemistry; Fucose - pharmacology; fucosylation inhibitor; FX (TSTA3); glycosylation; Guanosine Diphosphate Fucose - biosynthesis; HEK293 Cells; HeLa Cells; Humans; Ketone Oxidoreductases - antagonists & inhibitors; Ketone Oxidoreductases - metabolism; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; sugar analog; fucose; glycosylation; FX (TSTA3); sugar analog; fucosylation inhibitor