Cholecalciferol (vitamin D) differentially regulates antimicrobial peptide expression in bovine mammary epithelial cells: Implications during Staphylococcus aureus internalization

• Published in: Veterinary microbiology Vol. 160; no. 1-2; pp. 91 - 98
• Main Authors: Téllez-Pérez, Ana Dolores, Alva-Murillo, Nayeli, Ochoa-Zarzosa, Alejandra, López-Meza, Joel E.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 09.11.2012; Elsevier
• Subjects: Animals; Anti-Infective Agents; Anti-Infective Agents - metabolism; Anti-Infective Agents - pharmacology; Antimicrobial peptides; bacteria; bacterial infections; Bacteriology; beta-Defensins; beta-Defensins - biosynthesis; beta-Defensins - genetics; beta-Defensins - immunology; Biological and medical sciences; biosynthesis; Bovine mastitis; Cattle; Cells, Cultured; Cholecalciferol; Cholecalciferol - pharmacology; drug effects; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - immunology; Epithelial Cells - metabolism; Female; Fundamental and applied biological sciences. Psychology; gene expression; genes; genetics; hosts; immunity; immunology; mammary glands; Mammary Glands, Animal; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - immunology; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - microbiology; Mastitis, Bovine; Mastitis, Bovine - immunology; Mastitis, Bovine - microbiology; messenger RNA; metabolism; Microbiology; Miscellaneous; pharmacology; physiology; receptors; Staphylococcal Infections; Staphylococcal Infections - immunology; Staphylococcal Infections - microbiology; Staphylococcal Infections - veterinary; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics; Staphylococcus aureus - immunology; Staphylococcus aureus - physiology; Staphylococcus aureus internalization; veterinary; viability; Vitamin D; Vitamin D; Bovine mastitis; Epithelial cells; Staphylococcus aureus internalization; Cholecalciferol; Antimicrobial peptides; Mastitis; Bovine; Peptides; Antimicrobial agent; Mammary gland diseases; Vertebrata; Regulation(control); Mammalia; Bacteria; Micrococcales; Epithelial cell; Micrococcaceae; Artiodactyla; Veterinary; Ungulata; Staphylococcus aureus; Colecalciferol

Vitamin D has immunomodulatory functions regulating the expression of host defense genes. The aim of this study was to determine the effect of cholecalciferol (vitamin D3) on S. aureus internalization into bovine mammary epithelial cells (bMEC) and antimicrobial peptide (AP) mRNA expression. Choleca...