Onset of symptom resolution in adults with acute bacterial rhinosinusitis treated with a single dose of azithromycin extended release compared with 10 days of levofloxacin: A retrospective analysis of a randomized, double-blind, double-dummy trial

• Published in: Clinical therapeutics Vol. 29; no. 12; pp. 2690 - 2698
• Main Authors: Marple, Bradley F., MD, Roberts, Craig S., PharmD, MPA, de Caprariis, Pascal J., MD, Reisman, Arlene, MPH
• Format: Journal Article
• Language: English
• Published: Belle Mead, NJ EM Inc USA 01.12.2007; Excerpta Medica; Elsevier Limited
• Subjects: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Azithromycin - therapeutic use; Biological and medical sciences; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Internal Medicine; Levofloxacin; Male; Medical Education; Medical sciences; Middle Aged; Non tumoral diseases; Ofloxacin - therapeutic use; Otorhinolaryngology. Stomatology; Pharmacology. Drug treatments; Randomized Controlled Trials as Topic; Retrospective Studies; Rhinitis - drug therapy; Rhinitis - microbiology; Sinusitis - drug therapy; Sinusitis - microbiology; Treatment Outcome; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Levofloxacin; Nose disease; Rhinitis; Azithromycin; acute bacterial rhinosinusitis; Sinusitis; Fluoroquinolone derivatives; Randomization; Age of onset; symptom resolution; ENT disease; Adult; Bacteria; Clinical trial; Protein synthesis inhibitor; Quinolone derivatives; Human; Controlled release form; Acute; Single dose; Macrolide; Infection; Symptomatology; Antibiotic; Treatment; Follow up study; Dosage form; Bacteriosis; Double blind study; Paranasal sinus disease; Antibacterial agent; antibiotics; Comparative study

Abstract Background: A previous study found that a single 2-g dose of azithromycin extended release (AZ-ER) was as efficacious as 10 days of levofloxacin (LFX) 500 mg QD in adults with acute bacterial rhinosinusitis (ABRS). The speed with which patients experience resolution of ABRS symptoms has not...