Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study
Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s subjective perception of color changes in the e...
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Published in | Pharmaceutics Vol. 13; no. 6; p. 903 |
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Format | Journal Article |
Language | English |
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Abstract | Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s subjective perception of color changes in the endoscopy images. The objective of this study is to test the feasibility of gravitationally driven droplet translocation numerically to enhance the nasal spray dosages in the olfactory region and quantify the intranasal dose distribution in the regions of interest. A computational nasal spray testing platform was developed that included a nasal spray releasing model, an airflow-droplet transport model, and an Eulerian wall film formation/translocation model. The effects of both device-related and administration-related variables on the initial olfactory deposition were studied, including droplet size, velocity, plume angle, spray release position, and orientation. The liquid film formation and translocation after nasal spray applications were simulated for both a standard and a newly proposed delivery system. Results show that the initial droplet deposition in the olfactory region is highly sensitive to the spray plume angle. For the given nasal cavity with a vertex-to-floor head position, a plume angle of 10° with a device orientation of 45° to the nostril delivered the optimal dose to the olfactory region. Liquid wall film translocation enhanced the olfactory dosage by ninefold, compared to the initial olfactory dose, for both the baseline and optimized delivery systems. The optimized delivery system delivered 6.2% of applied sprays to the olfactory region and significantly reduced drug losses in the vestibule. Rheological properties of spray formulations can be explored to harness further the benefits of liquid film translocation in targeted intranasal deliveries. |
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AbstractList | Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s subjective perception of color changes in the endoscopy images. The objective of this study is to test the feasibility of gravitationally driven droplet translocation numerically to enhance the nasal spray dosages in the olfactory region and quantify the intranasal dose distribution in the regions of interest. A computational nasal spray testing platform was developed that included a nasal spray releasing model, an airflow-droplet transport model, and an Eulerian wall film formation/translocation model. The effects of both device-related and administration-related variables on the initial olfactory deposition were studied, including droplet size, velocity, plume angle, spray release position, and orientation. The liquid film formation and translocation after nasal spray applications were simulated for both a standard and a newly proposed delivery system. Results show that the initial droplet deposition in the olfactory region is highly sensitive to the spray plume angle. For the given nasal cavity with a vertex-to-floor head position, a plume angle of 10° with a device orientation of 45° to the nostril delivered the optimal dose to the olfactory region. Liquid wall film translocation enhanced the olfactory dosage by ninefold, compared to the initial olfactory dose, for both the baseline and optimized delivery systems. The optimized delivery system delivered 6.2% of applied sprays to the olfactory region and significantly reduced drug losses in the vestibule. Rheological properties of spray formulations can be explored to harness further the benefits of liquid film translocation in targeted intranasal deliveries. |
Author | Xi, Jinxiang Si, Xiuhua April Sami, Muhammad |
AuthorAffiliation | 1 Department of Aerospace, Industrial, and Mechanical Engineering, California Baptist University, Riverside, CA 92504, USA; asi@calbaptist.edu 2 ANSYS Inc., Houston, TX 77094, USA; Muhammad.Sami@ansys.com 3 Department of Biomedical Engineering, University of Massachusetts, Lowell, MA 01854, USA |
AuthorAffiliation_xml | – name: 1 Department of Aerospace, Industrial, and Mechanical Engineering, California Baptist University, Riverside, CA 92504, USA; asi@calbaptist.edu – name: 3 Department of Biomedical Engineering, University of Massachusetts, Lowell, MA 01854, USA – name: 2 ANSYS Inc., Houston, TX 77094, USA; Muhammad.Sami@ansys.com |
Author_xml | – sequence: 1 givenname: Xiuhua April surname: Si fullname: Si, Xiuhua April – sequence: 2 givenname: Muhammad surname: Sami fullname: Sami, Muhammad – sequence: 3 givenname: Jinxiang orcidid: 0000-0002-2536-2708 surname: Xi fullname: Xi, Jinxiang |
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CitedBy_id | crossref_primary_10_3390_pharmaceutics15061657 crossref_primary_10_1016_j_ijpharm_2023_122718 crossref_primary_10_3389_fvets_2023_1172140 crossref_primary_10_3390_biomedicines10061347 crossref_primary_10_1016_j_jaerosci_2021_105913 crossref_primary_10_2174_1389201023666220307092527 crossref_primary_10_3390_pharmaceutics15020359 crossref_primary_10_1016_j_jaerosci_2023_106246 crossref_primary_10_1063_5_0150890 crossref_primary_10_2174_1389201024666230801142913 crossref_primary_10_1002_mco2_101 crossref_primary_10_3390_pharmaceutics14050956 |
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Snippet | Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often... |
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SubjectTerms | Aerosols Bioavailability droplet deposition Drug dosages Endoscopy liquid film translocation nasal spray Nose nose-to-brain delivery olfactory dose Sinuses Velocity vertex-to-floor position |
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Title | Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study |
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