Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan

• Published in: Infection, genetics and evolution Vol. 12; no. 7; pp. 1524 - 1534
• Main Authors: Nakano, Tatsunori, Okano, Hiroshi, Kobayashi, Makoto, Ito, Keiichi, Ohmori, Shigeru, Nomura, Tomoyuki, Kato, Hideaki, Ayada, Minoru, Nakano, Yoko, Akachi, Shigehiro, Sugimoto, Kazushi, Fujita, Naoki, Shiraki, Katsuya, Takei, Yoshiyuki, Takahashi, Masaharu, Okamoto, Hiroaki
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.10.2012; Elsevier
• Subjects: Aged; Bayes Theorem; Biological and medical sciences; Coalescent analysis; Disease Outbreaks; Epidemiology. Vaccinations; Evolution, Molecular; Female; General aspects; Genotype; hepatitis E; Hepatitis E - epidemiology; Hepatitis E virus; Hepatitis E virus - genetics; Humans; Infectious diseases; Japan; Japan - epidemiology; Likelihood Functions; Male; Markov Chains; Medical sciences; Middle Aged; Models, Genetic; Molecular Epidemiology; Molecular Sequence Data; Monte Carlo Method; nucleotide sequences; Open Reading Frames; Phylogenetic analysis; Phylogeny; Phylogeography; risk factors; Sequence Analysis, DNA; Subtype 3e; Europe; Japan; Asia; Phylogenetic analysis; Coalescent analysis; BF; TMRCA; Japan; Subtype 3e; MCMC; Genotype; BSP; Hepatitis E virus; Typing; Phylogenetic tree; Case history; Virus; Infection; Calicivirus; Microbiological investigation; Caliciviridae; Molecular epidemiology; Subtype

► HEV subtype 3e strains are comparably rare in Japan. ► We encountered multiple patients infected with subtype 3e in Mie prefecture, Japan. ► The first report of persistent occurrence of hepatitis by HEV 3e outside of Europe. ► The Mie 3e strains seem to have intruded into Mie prefecture about 10ye...