Next-generation sequencing-based analysis of homologous recombination repair gene variant in ovarian cancer

• Published in: Heliyon Vol. 10; no. 2; p. e23684
• Main Authors: Song, Yaolin, Ran, Wenwen, Jia, Huiqing, Yao, Qin, Li, Guangqi, Chen, Yang, Wang, Xiaonan, Xiao, Yujing, Sun, Mengqi, Lu, Xiao, Xing, Xiaoming
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30.01.2024; Elsevier
• Subjects: BRCA1/2 mutation; Generation sequencing; Homologous recombination repair; Next; Ovarian cancer; Prognosis; Homologous recombination repair; Generation sequencing; Prognosis; BRCA1/2 mutation; Next; Ovarian cancer

Ovarian cancer is the leading cause of death from gynecological malignancies. Investigating the HRR-related gene status, notably BRCA1/2 in different regions and populations is of great significance for formulating accurate target therapy. We collected 124 ovarian cancer cases from the Affiliated Ho...