Antiplatelet agents in tissue factor–induced blood coagulation

• Published in: Blood Vol. 97; no. 8; pp. 2314 - 2322
• Main Authors: Butenas, Saulius, Cawthern, Kevin M., van't Veer, Cornelis, DiLorenzo, Maria E., Lock, Jennifer B., Mann, Kenneth G.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 15.04.2001; The Americain Society of Hematology
• Subjects: Abciximab; Adult; Alprostadil - pharmacology; Animals; Antibodies, Monoclonal - pharmacology; Antithrombin III - biosynthesis; Aspirin - pharmacology; Biological and medical sciences; Blood Coagulation - drug effects; Blood. Blood coagulation. Reticuloendothelial system; Dipyridamole - pharmacology; Eptifibatide; Fibrinopeptide A - analysis; Humans; Immunoglobulin Fab Fragments - pharmacology; Medical sciences; Mice; Osteonectin - metabolism; Partial Thromboplastin Time; Peptide Hydrolases - biosynthesis; Peptides - pharmacology; Pharmacology. Drug treatments; Plant Proteins - pharmacology; Platelet Activation - drug effects; Platelet Aggregation Inhibitors - pharmacology; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors; Proteins - pharmacology; Prothrombin Time; Receptors, Thrombin; Thromboplastin - pharmacology; Human; Blood coagulation; Serine endopeptidases; Enzyme; Clotting time; Tissue factor; Thrombin; Biological activity; Antiplatelet agent; Whole blood; Peptidases; Platelet; Hemostasis; Hydrolases; Coagulation factor; EC 3.4.21.5

Several platelet inhibitors were examined in a tissue factor (TF)–initiated model of whole blood coagulation. In vitro coagulation of human blood from normal donors was initiated by 25 pM TF while contact pathway coagulation was suppressed using corn trypsin inhibitor. Products of the reaction were...