Atherosclerosis Burdens in Diabetes Mellitus: Assessment by PET Imaging
Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of death worldwide, fatalities having doubled since 2000. The literature in the field claims almost unanimously that arteriosclerosis is more fr...
Saved in:
| Published in | International journal of molecular sciences Vol. 23; no. 18; p. 10268 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel
MDPI AG
06.09.2022
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1422-0067 1661-6596 1422-0067 |
| DOI | 10.3390/ijms231810268 |
Cover
Loading…
| Abstract | Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of death worldwide, fatalities having doubled since 2000. The literature in the field claims almost unanimously that arteriosclerosis is more frequent or develops more rapidly in diabetic than non-diabetic subjects, and that the disease is caused by arterial inflammation, the control of which should therefore be the goal of therapeutic efforts. These views are mostly based on indirect methodologies, including studies of artery wall thickness or stiffness, or on conventional CT-based imaging used to demonstrate tissue changes occurring late in the disease process. In contrast, imaging with positron emission tomography and computed tomography (PET/CT) applying the tracers 18F-fluorodeoxyglucose (FDG) or 18F-sodium fluoride (NaF) mirrors arterial wall inflammation and microcalcification, respectively, early in the course of the disease, potentially enabling in vivo insight into molecular processes. The present review provides an overview of the literature from the more than 20 and 10 years, respectively, that these two tracers have been used for the study of atherosclerosis, with emphasis on what new information they have provided in relation to diabetes and which questions remain insufficiently elucidated. |
|---|---|
| AbstractList | Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of death worldwide, fatalities having doubled since 2000. The literature in the field claims almost unanimously that arteriosclerosis is more frequent or develops more rapidly in diabetic than non-diabetic subjects, and that the disease is caused by arterial inflammation, the control of which should therefore be the goal of therapeutic efforts. These views are mostly based on indirect methodologies, including studies of artery wall thickness or stiffness, or on conventional CT-based imaging used to demonstrate tissue changes occurring late in the disease process. In contrast, imaging with positron emission tomography and computed tomography (PET/CT) applying the tracers 18F-fluorodeoxyglucose (FDG) or 18F-sodium fluoride (NaF) mirrors arterial wall inflammation and microcalcification, respectively, early in the course of the disease, potentially enabling in vivo insight into molecular processes. The present review provides an overview of the literature from the more than 20 and 10 years, respectively, that these two tracers have been used for the study of atherosclerosis, with emphasis on what new information they have provided in relation to diabetes and which questions remain insufficiently elucidated. Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of death worldwide, fatalities having doubled since 2000. The literature in the field claims almost unanimously that arteriosclerosis is more frequent or develops more rapidly in diabetic than non-diabetic subjects, and that the disease is caused by arterial inflammation, the control of which should therefore be the goal of therapeutic efforts. These views are mostly based on indirect methodologies, including studies of artery wall thickness or stiffness, or on conventional CT-based imaging used to demonstrate tissue changes occurring late in the disease process. In contrast, imaging with positron emission tomography and computed tomography (PET/CT) applying the tracers 18F-fluorodeoxyglucose (FDG) or 18F-sodium fluoride (NaF) mirrors arterial wall inflammation and microcalcification, respectively, early in the course of the disease, potentially enabling in vivo insight into molecular processes. The present review provides an overview of the literature from the more than 20 and 10 years, respectively, that these two tracers have been used for the study of atherosclerosis, with emphasis on what new information they have provided in relation to diabetes and which questions remain insufficiently elucidated.Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of death worldwide, fatalities having doubled since 2000. The literature in the field claims almost unanimously that arteriosclerosis is more frequent or develops more rapidly in diabetic than non-diabetic subjects, and that the disease is caused by arterial inflammation, the control of which should therefore be the goal of therapeutic efforts. These views are mostly based on indirect methodologies, including studies of artery wall thickness or stiffness, or on conventional CT-based imaging used to demonstrate tissue changes occurring late in the disease process. In contrast, imaging with positron emission tomography and computed tomography (PET/CT) applying the tracers 18F-fluorodeoxyglucose (FDG) or 18F-sodium fluoride (NaF) mirrors arterial wall inflammation and microcalcification, respectively, early in the course of the disease, potentially enabling in vivo insight into molecular processes. The present review provides an overview of the literature from the more than 20 and 10 years, respectively, that these two tracers have been used for the study of atherosclerosis, with emphasis on what new information they have provided in relation to diabetes and which questions remain insufficiently elucidated. Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of death worldwide, fatalities having doubled since 2000. The literature in the field claims almost unanimously that arteriosclerosis is more frequent or develops more rapidly in diabetic than non-diabetic subjects, and that the disease is caused by arterial inflammation, the control of which should therefore be the goal of therapeutic efforts. These views are mostly based on indirect methodologies, including studies of artery wall thickness or stiffness, or on conventional CT-based imaging used to demonstrate tissue changes occurring late in the disease process. In contrast, imaging with positron emission tomography and computed tomography (PET/CT) applying the tracers 18 F-fluorodeoxyglucose (FDG) or 18 F-sodium fluoride (NaF) mirrors arterial wall inflammation and microcalcification, respectively, early in the course of the disease, potentially enabling in vivo insight into molecular processes. The present review provides an overview of the literature from the more than 20 and 10 years, respectively, that these two tracers have been used for the study of atherosclerosis, with emphasis on what new information they have provided in relation to diabetes and which questions remain insufficiently elucidated. |
| Author | Alavi, Abass Gerke, Oke Høilund-Carlsen, Poul F. Revheim, Mona-Elisabeth Werner, Thomas J. Piri, Reza Madsen, Per Lav Sturek, Michael |
| AuthorAffiliation | 4 Division of Radiology and Nuclear Medicine, Oslo University Hospital, 0424 Oslo, Norway 1 Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark 3 Department of Cardiology, Herlev Gentofte Hospital, 2900 Herlev, Denmark 5 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0315 Oslo, Norway 6 Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 2 Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark 7 Department of Anatomy, Cell Biology, Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA |
| AuthorAffiliation_xml | – name: 6 Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA – name: 2 Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark – name: 7 Department of Anatomy, Cell Biology, Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA – name: 3 Department of Cardiology, Herlev Gentofte Hospital, 2900 Herlev, Denmark – name: 5 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0315 Oslo, Norway – name: 1 Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark – name: 4 Division of Radiology and Nuclear Medicine, Oslo University Hospital, 0424 Oslo, Norway |
| Author_xml | – sequence: 1 givenname: Poul F. orcidid: 0000-0001-7420-2367 surname: Høilund-Carlsen fullname: Høilund-Carlsen, Poul F. – sequence: 2 givenname: Reza orcidid: 0000-0002-6379-3373 surname: Piri fullname: Piri, Reza – sequence: 3 givenname: Per Lav surname: Madsen fullname: Madsen, Per Lav – sequence: 4 givenname: Mona-Elisabeth orcidid: 0000-0003-3300-7420 surname: Revheim fullname: Revheim, Mona-Elisabeth – sequence: 5 givenname: Thomas J. surname: Werner fullname: Werner, Thomas J. – sequence: 6 givenname: Abass surname: Alavi fullname: Alavi, Abass – sequence: 7 givenname: Oke orcidid: 0000-0001-6335-3303 surname: Gerke fullname: Gerke, Oke – sequence: 8 givenname: Michael orcidid: 0000-0002-2920-7406 surname: Sturek fullname: Sturek, Michael |
| BookMark | eNptkUtP3TAQha0KpPJadt1IbLoJ2I6fXSDdUl4SCBZ0bTmOc_FVYlOPU4l_30SABIjNeKT55pzxzC7aiil6hL4RfNQ0Gh-HzQi0IYpgKtQXtEMYpTXGQm69yb-iXYANxrShXO-gi1V58DmBG5YYoPo15c5HqEKsfgfb-uKhuvHDEMoEP6sVgAcYfSxV-1Tdnd1XV6Ndh7jeR9u9HcAfvLx76M_52f3pZX19e3F1urquHVO01AQ3tO-497RnkvdcKSYkaRkjTslOO6mJ4qzrWqq9cMp1qneaSUGwJppR3uyhk2fdx6kdfefmSbIdzGMOo81PJtlg3ldieDDr9M9oprUgZBb4_izgcoASookpW0Ow4tRozfBi8ePFIqe_k4dixgBuXoGNPk1gqCRSKEGVmtHDD-gmTTnOC1gowbnUjM1U82qZALLvjQvFlpCWCcMwm5vlfubd_eau-kPX6yc_5_8D-_-dCQ |
| CitedBy_id | crossref_primary_10_1007_s12149_023_01875_4 crossref_primary_10_1021_acssensors_2c02590 crossref_primary_10_1016_j_cpcardiol_2023_101925 crossref_primary_10_62347_NLLM5784 crossref_primary_10_3390_ph17070929 crossref_primary_10_1152_ajpheart_00539_2024 crossref_primary_10_1016_j_atherosclerosis_2023_117275 crossref_primary_10_1021_acs_jmedchem_3c00720 |
| Cites_doi | 10.1016/S0140-6736(10)60484-9 10.1016/j.jcmg.2011.08.007 10.1007/s00259-015-3259-3 10.1161/01.CIR.0000033824.02722.F7 10.1007/s11606-015-3556-3 10.1111/dom.14717 10.1161/CIRCIMAGING.118.007835 10.1016/j.cpet.2018.12.001 10.1016/j.atherosclerosis.2022.03.019 10.2337/diacare.21.11.1861 10.1161/hc0902.104353 10.1038/ncomms8495 10.1007/s12350-021-02533-w 10.1016/j.jcmg.2011.07.009 10.1007/s13139-014-0277-1 10.1038/362801a0 10.1016/j.atherosclerosis.2020.03.029 10.1097/RLU.0b013e3180646ac0 10.3390/diagnostics10100852 10.1097/RLU.0b013e3182817c4c 10.1007/s00259-018-4078-0 10.1161/ATVBAHA.120.315364 10.1097/00003072-200104000-00007 10.1007/s12350-021-02589-8 10.1007/s12350-013-9680-8 10.1053/ajkd.2001.27440 10.1161/01.CIR.0000091257.27563.32 10.1001/archinte.161.13.1581 10.1111/j.1464-5491.2008.02640.x 10.1177/026765919601100502 10.1016/j.jacc.2011.11.069 10.1056/NEJM199807233390404 10.1007/s11682-016-9583-9 10.1016/j.nicl.2020.102302 10.1007/s12350-019-01842-5 10.1186/s12872-016-0397-x 10.1007/s12350-020-02099-z 10.1089/dia.2006.8.1 10.1016/j.jcmg.2013.09.004 10.1007/s12350-021-02781-w 10.1016/j.atherosclerosis.2019.09.016 10.1186/s12933-016-0340-6 10.1038/s41598-020-77391-6 10.1097/RLU.0000000000001695 10.1007/s00259-017-3671-y 10.2337/diacare.27.3.813 10.1093/ajcn/nqz147 10.1016/j.jcmg.2018.05.013 10.1590/S0104-11692007000300023 10.1093/ajcn/nqab306 10.1113/JP271340 10.2337/diacare.22.2.233 10.1161/ATVBAHA.118.311711 10.1007/s00259-019-04603-1 10.3390/ijms21051835 10.1161/ATVBAHA.116.307293 10.1007/s10554-013-0277-8 10.1007/BF00276995 10.7547/1020240 10.1007/s12350-017-0977-x 10.1161/CIRCIMAGING.109.888909 10.1152/ajpheart.00220.2020 10.1007/s00259-009-1297-4 10.2337/dc16-0327 10.2337/dc12-0087 10.1161/CIRCIMAGING.120.012174 10.1371/journal.pone.0131332 10.5551/jat.15669 10.1161/01.CIR.0000147540.88559.00 10.2967/jnumed.110.076471 10.1177/1479164112436403 10.1016/j.atherosclerosis.2011.11.008 10.1007/s11886-019-1107-y |
| ContentType | Journal Article |
| Copyright | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. info:eu-repo/semantics/openAccess 2022 by the authors. 2022 |
| Copyright_xml | – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: info:eu-repo/semantics/openAccess – notice: 2022 by the authors. 2022 |
| DBID | AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8 3HK 5PM |
| DOI | 10.3390/ijms231810268 |
| DatabaseName | CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni) Medical Database Research Library Research Library (Corporate) ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic NORA - Norwegian Open Research Archives PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database CrossRef |
| Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central (New) (NC LIVE) url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1422-0067 |
| ExternalDocumentID | PMC9499611 10852_99405 10_3390_ijms231810268 |
| GroupedDBID | --- 29J 2WC 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AFKRA AFZYC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU CITATION CS3 D1I DIK DU5 DWQXO E3Z EBD EBS EJD ESX F5P FRP FYUFA GNUQQ GUQSH GX1 HH5 HMCUK HYE IAO IHR ITC KQ8 LK8 M1P M2O M48 MODMG O5R O5S OK1 OVT P2P PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO RNS RPM TR2 TUS UKHRP ~8M 3V. 7XB 8FK K9. MBDVC PJZUB PKEHL PPXIY PQEST PQUKI PRINS Q9U 7X8 3HK ADRAZ C1A IPNFZ RIG 5PM |
| ID | FETCH-LOGICAL-c482t-1032fd5ee2f475f5884671b441c87d9c791854ddb29e6c8cd8fc9476109194253 |
| IEDL.DBID | M48 |
| ISSN | 1422-0067 1661-6596 |
| IngestDate | Thu Aug 21 18:39:50 EDT 2025 Tue May 06 06:43:33 EDT 2025 Fri Jul 11 09:05:52 EDT 2025 Fri Jul 25 20:18:51 EDT 2025 Tue Jul 01 03:40:31 EDT 2025 Thu Apr 24 23:11:49 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 18 |
| Language | English |
| License | https://creativecommons.org/licenses/by/4.0 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c482t-1032fd5ee2f475f5884671b441c87d9c791854ddb29e6c8cd8fc9476109194253 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0001-7420-2367 0000-0003-3300-7420 0000-0002-6379-3373 0000-0001-6335-3303 0000-0002-2920-7406 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/ijms231810268 |
| PQID | 2716557944 |
| PQPubID | 2032341 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_9499611 cristin_nora_10852_99405 proquest_miscellaneous_2717686288 proquest_journals_2716557944 crossref_citationtrail_10_3390_ijms231810268 crossref_primary_10_3390_ijms231810268 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20220906 |
| PublicationDateYYYYMMDD | 2022-09-06 |
| PublicationDate_xml | – month: 9 year: 2022 text: 20220906 day: 6 |
| PublicationDecade | 2020 |
| PublicationPlace | Basel |
| PublicationPlace_xml | – name: Basel |
| PublicationTitle | International journal of molecular sciences |
| PublicationYear | 2022 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Janssen (ref_32) 2013; 20 Bellinge (ref_48) 2022; 115 Bellinge (ref_47) 2022; 29 Mizoguchi (ref_41) 2011; 4 Yamashita (ref_16) 2013; 20 Bulugahapitiya (ref_68) 2009; 26 ref_53 Bucerius (ref_76) 2016; 43 Moghbel (ref_4) 2019; 14 Cruickshank (ref_62) 2002; 106 Yang (ref_24) 2012; 220 Juonala (ref_63) 2004; 110 Alavi (ref_21) 2018; 25 Chau (ref_10) 2020; 27 Cui (ref_9) 2017; 11 Heerspink (ref_27) 2016; 39 Niskanen (ref_58) 1998; 21 Sivalingam (ref_13) 2022; 24 ref_69 Creager (ref_5) 2003; 108 Assante (ref_11) 2017; 44 Basu (ref_17) 2007; 32 Raggi (ref_35) 2019; 39 Libby (ref_61) 2002; 105 Saraste (ref_23) 2011; 4 Boswijk (ref_49) 2021; 61 Coutinho (ref_59) 1999; 22 Yun (ref_30) 2001; 26 ref_26 Derlin (ref_51) 2010; 51 Haffner (ref_57) 1998; 339 Tahara (ref_31) 2012; 35 Glovaci (ref_72) 2019; 21 Pickup (ref_64) 2004; 27 Creager (ref_3) 2019; 12 Creager (ref_6) 2003; 108 Moss (ref_73) 2020; 10 Irkle (ref_2) 2015; 6 Bellinge (ref_40) 2021; 41 Reijrink (ref_39) 2022; 29 ref_33 Bural (ref_34) 2017; 20 Assante (ref_12) 2021; 28 Kapustin (ref_75) 2016; 594 Nawaz (ref_18) 2012; 102 Hellberg (ref_29) 2016; 15 Field (ref_60) 2001; 161 Santos (ref_77) 2007; 15 Bucerius (ref_25) 2012; 59 Virta (ref_44) 2020; 305 Boellaard (ref_50) 2009; 37 Takx (ref_38) 2021; 28 Pallas (ref_8) 1996; 11 Kim (ref_22) 2010; 3 Nitta (ref_42) 2013; 6 Honda (ref_28) 2016; 36 Reijrink (ref_67) 2019; 290 Zwakenberg (ref_43) 2019; 110 Marre (ref_19) 2013; 38 Lee (ref_37) 2014; 48 Alavi (ref_20) 2017; 42 Ripa (ref_46) 2021; 14 Moghbel (ref_52) 2018; 45 (ref_74) 2018; 11 Sturek (ref_54) 2020; 47 Shi (ref_66) 2020; 319 Rana (ref_71) 2016; 31 Bisgaard (ref_15) 2022; 350 ref_1 Uusitupa (ref_55) 1985; 28 Ishimura (ref_14) 2001; 38 Ross (ref_56) 1993; 362 Pickup (ref_65) 2006; 8 Strobl (ref_36) 2013; 29 Wong (ref_70) 2012; 9 ref_7 Tahara (ref_45) 2020; 27 |
| References_xml | – ident: ref_69 doi: 10.1016/S0140-6736(10)60484-9 – volume: 4 start-page: 1110 year: 2011 ident: ref_41 article-title: Pioglitazone Attenuates Atherosclerotic Plaque Inflammation in Patients with Impaired Glucose Tolerance or Diabetes: A Prospective, Randomized, Comparator-Controlled Study Using Serial FDG PET/CT Imaging Study of Carotid Artery and Ascending Aorta publication-title: JACC Cardiovasc. Imaging doi: 10.1016/j.jcmg.2011.08.007 – volume: 43 start-page: 780 year: 2016 ident: ref_76 article-title: Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-015-3259-3 – volume: 106 start-page: 2085 year: 2002 ident: ref_62 article-title: Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose Intolerance publication-title: Circulation doi: 10.1161/01.CIR.0000033824.02722.F7 – volume: 31 start-page: 387 year: 2016 ident: ref_71 article-title: Diabetes and Prior Coronary Heart Disease are Not Necessarily Risk Equivalent for Future Coronary Heart Disease Events publication-title: J. Gen. Intern. Med. doi: 10.1007/s11606-015-3556-3 – volume: 24 start-page: 1638 year: 2022 ident: ref_13 article-title: The effect of liraglutide on cardiac autonomic function in type 2 diabetes: A prespecified secondary analysis from the LIRAFLAME randomized, double-blinded, placebo-controlled trial publication-title: Diabetes Obes. Metab. doi: 10.1111/dom.14717 – volume: 12 start-page: e007835 year: 2019 ident: ref_3 article-title: 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated with Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images publication-title: Circ. Cardiovasc. Imaging doi: 10.1161/CIRCIMAGING.118.007835 – volume: 14 start-page: 197 year: 2019 ident: ref_4 article-title: Evolving role of PET in detecting and characterizing atherosclerosis publication-title: PET Clin. doi: 10.1016/j.cpet.2018.12.001 – volume: 20 start-page: 192 year: 2017 ident: ref_34 article-title: Is 18F-FDG PET/CT a valuable diagnostic tool for verifying accelerated atherosclerosis secondary to diabetes mellitus on insulin in the aortic segments and large arteries? publication-title: Hell. J. Nucl. Med. – volume: 350 start-page: 109 year: 2022 ident: ref_15 article-title: The metabolic signature of cardiovascular disease and arterial calcification in patients with chronic kidney disease publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2022.03.019 – volume: 21 start-page: 1861 year: 1998 ident: ref_58 article-title: Hyperglycemia and compositional lipoprotein abnormalities as predictors of cardiovascular mortality in type 2 diabetes: A 15-year follow-up from the time of diagnosis publication-title: Diabetes Care doi: 10.2337/diacare.21.11.1861 – volume: 105 start-page: 1135 year: 2002 ident: ref_61 article-title: Inflammation and atherosclerosis publication-title: Circulation doi: 10.1161/hc0902.104353 – volume: 6 start-page: 7495 year: 2015 ident: ref_2 article-title: Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography publication-title: Nat. Commun. doi: 10.1038/ncomms8495 – volume: 28 start-page: 1222 year: 2021 ident: ref_12 article-title: Relation between myocardial blood flow and cardiac events in diabetic patients with suspected coronary artery disease and normal myocardial perfusion imaging publication-title: J. Nucl. Cardiol. doi: 10.1007/s12350-021-02533-w – volume: 4 start-page: 1294 year: 2011 ident: ref_23 article-title: Effects of Age, Diet, and Type 2 Diabetes on the Development and FDG Uptake of Atherosclerotic Plaques publication-title: JACC Cardiovasc. Imaging doi: 10.1016/j.jcmg.2011.07.009 – volume: 48 start-page: 196 year: 2014 ident: ref_37 article-title: Carotid Artery FDG Uptake May Serve as a Biomarker for Cardiovascular Risk Stratification in Asymptomatic Adults publication-title: Nucl. Med. Mol. Imaging doi: 10.1007/s13139-014-0277-1 – volume: 362 start-page: 801 year: 1993 ident: ref_56 article-title: The pathogenesis of atherosclerosis: A perspective for the 1990s publication-title: Nature doi: 10.1038/362801a0 – ident: ref_1 – volume: 305 start-page: 64 year: 2020 ident: ref_44 article-title: Effects of dipeptidyl peptidase 4 inhibition on inflammation in atherosclerosis: A 18F-fluorodeoxyglucose study of a mouse model of atherosclerosis and type 2 diabetes publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2020.03.029 – volume: 32 start-page: 567 year: 2007 ident: ref_17 article-title: Imaging of Lower Extremity Artery Atherosclerosis in Diabetic Foot: FDG-PET Imaging and Histopathological Correlates publication-title: Clin. Nucl. Med. doi: 10.1097/RLU.0b013e3180646ac0 – ident: ref_53 doi: 10.3390/diagnostics10100852 – volume: 38 start-page: 269 year: 2013 ident: ref_19 article-title: (18)F-FDG PET/CT imaging of critical ischemia in the diabetic foot publication-title: Clin. Nucl. Med. doi: 10.1097/RLU.0b013e3182817c4c – volume: 45 start-page: 2190 year: 2018 ident: ref_52 article-title: 18F-NaF and 18F-FDG as molecular probes in the evaluation of atherosclerosis publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-018-4078-0 – volume: 41 start-page: 534 year: 2021 ident: ref_40 article-title: 18F-Sodium Fluoride Positron Emission Tomography Activity Predicts the Development of New Coronary Artery Calcifications publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.120.315364 – volume: 26 start-page: 314 year: 2001 ident: ref_30 article-title: F-18 FDG Uptake in the Large Arteries: A New Observation publication-title: Clin. Nucl. Med. doi: 10.1097/00003072-200104000-00007 – volume: 29 start-page: 1855 year: 2022 ident: ref_47 article-title: The effect of Vitamin-K1 and Colchicine on Vascular Calcification Activity in subjects with Diabetes Mellitus (ViKCoVaC): A double-blind 2x2 factorial randomized controlled trial publication-title: J. Nucl. Cardiol. doi: 10.1007/s12350-021-02589-8 – volume: 20 start-page: 569 year: 2013 ident: ref_32 article-title: Association of linear 18F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: A PET/CT study publication-title: J. Nucl. Cardiol. doi: 10.1007/s12350-013-9680-8 – volume: 38 start-page: S186 year: 2001 ident: ref_14 article-title: Renal insufficiency accelerates atherosclerosis in patients with type 2 diabetes mellitus publication-title: Am. J. Kidney Dis. doi: 10.1053/ajkd.2001.27440 – volume: 108 start-page: 1655 year: 2003 ident: ref_6 article-title: Diabetes and Vascular Disease. Pathophysiology, Clinical Consequences, and Medical Therapy: Part II publication-title: Circulation doi: 10.1161/01.CIR.0000091257.27563.32 – volume: 161 start-page: 1581 year: 2001 ident: ref_60 article-title: Impact of Overweight on the Risk of Developing Common Chronic Diseases During a 10-Year Period publication-title: Arch. Intern. Med. doi: 10.1001/archinte.161.13.1581 – volume: 26 start-page: 142 year: 2009 ident: ref_68 article-title: Is diabetes a coronary risk equivalent? Systematic review and meta-analysis publication-title: Diabet. Med. doi: 10.1111/j.1464-5491.2008.02640.x – volume: 11 start-page: 363 year: 1996 ident: ref_8 article-title: Cerebral blood flow in the diabetic patient publication-title: Perfusion doi: 10.1177/026765919601100502 – volume: 61 start-page: 33 year: 2021 ident: ref_49 article-title: Resveratrol treatment does not reduce arterial inflammation in males at risk of type 2 diabetes: A randomized crossover trial publication-title: Nuklearmedizin – volume: 59 start-page: 2080 year: 2012 ident: ref_25 article-title: Impact of Noninsulin-Dependent Type 2 Diabetes on Carotid Wall 18F-Fluorodeoxyglucose Positron Emission Tomography Uptake publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2011.11.069 – volume: 339 start-page: 229 year: 1998 ident: ref_57 article-title: Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199807233390404 – volume: 11 start-page: 1248 year: 2017 ident: ref_9 article-title: Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction publication-title: Brain Imaging Behav. doi: 10.1007/s11682-016-9583-9 – volume: 27 start-page: 102302 year: 2020 ident: ref_10 article-title: Impaired cerebral blood flow in type 2 diabetes mellitus—A comparative study with subjective cognitive decline, vascular dementia and Alzheimer’s disease subjects publication-title: NeuroImage Clin. doi: 10.1016/j.nicl.2020.102302 – volume: 27 start-page: 1352 year: 2020 ident: ref_45 article-title: Two-hour postload plasma glucose and pigment epithelium-derived factor levels are markers of coronary artery inflammation in type 2 diabetic patients publication-title: J. Nucl. Cardiol. doi: 10.1007/s12350-019-01842-5 – ident: ref_33 doi: 10.1186/s12872-016-0397-x – volume: 28 start-page: 2700 year: 2021 ident: ref_38 article-title: Determinants of 18F-NaF uptake in femoral arteries in patients with type 2 diabetes mellitus publication-title: J. Nucl. Cardiol. doi: 10.1007/s12350-020-02099-z – volume: 8 start-page: 1 year: 2006 ident: ref_65 article-title: Inflammatory markers and type 2 diabetes publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2006.8.1 – volume: 6 start-page: 1172 year: 2013 ident: ref_42 article-title: Pioglitazone Decreases Coronary Artery Inflammation in Impaired Glucose Tolerance and Diabetes Mellitus publication-title: JACC Cardiovasc. Imaging doi: 10.1016/j.jcmg.2013.09.004 – volume: 29 start-page: 1702 year: 2022 ident: ref_39 article-title: [18F]FDG and [18F]NaF as PET markers of systemic atherosclerosis progression: A longitudinal descriptive imaging study in patients with type 2 diabetes mellitus publication-title: J. Nucl. Cardiol. doi: 10.1007/s12350-021-02781-w – volume: 290 start-page: 87 year: 2019 ident: ref_67 article-title: Visceral adipose tissue volume is associated with premature atherosclerosis in early type 2 diabetes mellitus independent of traditional risk factors publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2019.09.016 – volume: 15 start-page: 26 year: 2016 ident: ref_29 article-title: Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: An imaging study with positron emission tomography tracer 18F-fluoromethylcholine publication-title: Cardiovasc. Diabetol. doi: 10.1186/s12933-016-0340-6 – volume: 10 start-page: 20172 year: 2020 ident: ref_73 article-title: Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis publication-title: Sci. Rep. doi: 10.1038/s41598-020-77391-6 – volume: 42 start-page: 603 year: 2017 ident: ref_20 article-title: What Can Be and What Cannot Be Accomplished with PET: Rectifying Ongoing Misconceptions publication-title: Clin. Nucl. Med. doi: 10.1097/RLU.0000000000001695 – volume: 44 start-page: 1129 year: 2017 ident: ref_11 article-title: Coronary atherosclerotic burden vs. coronary vascular function in diabetic and nondiabetic patients with normal myocardial perfusion: A propensity score analysis publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-017-3671-y – volume: 27 start-page: 813 year: 2004 ident: ref_64 article-title: Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes publication-title: Diabetes Care doi: 10.2337/diacare.27.3.813 – volume: 110 start-page: 883 year: 2019 ident: ref_43 article-title: The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: A randomized, double-blind, placebo-controlled trial publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/nqz147 – volume: 11 start-page: 1485 year: 2018 ident: ref_74 article-title: Monitoring the Response to Statin Therapy publication-title: JACC Cardiovasc. Imaging doi: 10.1016/j.jcmg.2018.05.013 – volume: 15 start-page: 508 year: 2007 ident: ref_77 article-title: The PICO strategy for the research question construction and evidence search publication-title: Rev. Lat. Am. Enferm. doi: 10.1590/S0104-11692007000300023 – volume: 115 start-page: 45 year: 2022 ident: ref_48 article-title: The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: A post hoc analysis of a double-blind, randomized, placebo-controlled trial publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/nqab306 – volume: 594 start-page: 2905 year: 2016 ident: ref_75 article-title: Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation publication-title: J. Physiol. doi: 10.1113/JP271340 – volume: 22 start-page: 233 year: 1999 ident: ref_59 article-title: The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years publication-title: Diabetes Care doi: 10.2337/diacare.22.2.233 – volume: 108 start-page: 1527 year: 2003 ident: ref_5 article-title: Diabetes and Vascular Disease. Pathophysiology, Clinical Consequences, and Medical Therapy: Part I publication-title: Circulation doi: 10.1161/01.CIR.0000091257.27563.32 – volume: 39 start-page: 276 year: 2019 ident: ref_35 article-title: 18F-Sodium Fluoride Imaging of Coronary Atherosclerosis in Ambulatory Patients with Diabetes Mellitus publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.118.311711 – volume: 47 start-page: 1538 year: 2020 ident: ref_54 article-title: Atherosclerosis imaging with 18F-sodium fluoride PET: State-of-the-art review publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-019-04603-1 – ident: ref_7 doi: 10.3390/ijms21051835 – volume: 36 start-page: 1980 year: 2016 ident: ref_28 article-title: Vascular Inflammation Evaluated by [18F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated with Endothelial Dysfunction publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.116.307293 – volume: 29 start-page: 1899 year: 2013 ident: ref_36 article-title: Impact of cardiovascular risk factors on vessel wall inflammation and calcified plaque burden differs across vascular beds: A PET-CT study publication-title: Int. J. Cardiovasc. Imaging doi: 10.1007/s10554-013-0277-8 – volume: 28 start-page: 22 year: 1985 ident: ref_55 article-title: Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed Type 2 (non-insulin-dependent) diabetic subjects publication-title: Diabetologia doi: 10.1007/BF00276995 – volume: 102 start-page: 240 year: 2012 ident: ref_18 article-title: Relation Between Popliteal-Tibial Artery Atherosclerosis and Global Glycolytic Metabolism in the Affected Diabetic Foot: A Pilot Study Using Quantitative FDG-PET publication-title: J. Am. Podiatr. Med. Assoc. doi: 10.7547/1020240 – volume: 25 start-page: 2012 year: 2018 ident: ref_21 article-title: What can be and what cannot be accomplished with PET to detect and characterize atherosclerotic plaques publication-title: J. Nucl. Cardiol. doi: 10.1007/s12350-017-0977-x – volume: 3 start-page: 142 year: 2010 ident: ref_22 article-title: Vascular Inflammation in Patients with Impaired Glucose Tolerance and Type 2 Diabetes publication-title: Circ. Cardiovasc. Imaging doi: 10.1161/CIRCIMAGING.109.888909 – volume: 319 start-page: H613 year: 2020 ident: ref_66 article-title: Metabolism of vascular smooth muscle cells in vascular diseases publication-title: Am. J. Physiol.-Heart Circ. Physiol. doi: 10.1152/ajpheart.00220.2020 – volume: 37 start-page: 181 year: 2009 ident: ref_50 article-title: FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: Version 1.0 publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-009-1297-4 – volume: 39 start-page: 1440 year: 2016 ident: ref_27 article-title: Arterial Stiffness Is Positively Associated with 18F-fluorodeoxyglucose Positron Emission Tomography–Assessed Subclinical Vascular Inflammation in People with Early Type 2 Diabetes publication-title: Diabetes Care doi: 10.2337/dc16-0327 – volume: 35 start-page: 2618 year: 2012 ident: ref_31 article-title: Positive Association Between Serum Level of Glyceraldehyde-Derived Advanced Glycation End Products and Vascular Inflammation Evaluated by [18F]Fluorodeoxyglucose Positron Emission Tomography publication-title: Diabetes Care doi: 10.2337/dc12-0087 – volume: 14 start-page: e012174 year: 2021 ident: ref_46 article-title: Effect of Liraglutide on Arterial Inflammation Assessed as [18F]FDG Uptake in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial publication-title: Circ. Cardiovasc. Imaging doi: 10.1161/CIRCIMAGING.120.012174 – ident: ref_26 doi: 10.1371/journal.pone.0131332 – volume: 20 start-page: 790 year: 2013 ident: ref_16 article-title: Renal Insufficiency without Albuminuria is Associated with Peripheral Artery Atherosclerosis and Lipid Metabolism Disorders in Patients with Type 2 Diabetes publication-title: J. Atheroscler. Thromb. doi: 10.5551/jat.15669 – volume: 110 start-page: 2918 year: 2004 ident: ref_63 article-title: Interrelations Between Brachial Endothelial Function and Carotid Intima-Media Thickness in Young Adults publication-title: Circulation doi: 10.1161/01.CIR.0000147540.88559.00 – volume: 51 start-page: 862 year: 2010 ident: ref_51 article-title: Feasibility of 18F-Sodium Fluoride PET/CT for Imaging of Atherosclerotic Plaque publication-title: J. Nucl. Med. doi: 10.2967/jnumed.110.076471 – volume: 9 start-page: 146 year: 2012 ident: ref_70 article-title: Global cardiovascular disease risk assessment in United States adults with diabetes publication-title: Diabetes Vasc. Dis. Res. doi: 10.1177/1479164112436403 – volume: 220 start-page: 402 year: 2012 ident: ref_24 article-title: Association between sRAGE, esRAGE levels and vascular inflammation: Analysis with 18F-fluorodeoxyglucose positron emission tomography publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2011.11.008 – volume: 21 start-page: 21 year: 2019 ident: ref_72 article-title: Epidemiology of Diabetes Mellitus and Cardiovascular Disease publication-title: Curr. Cardiol. Rep. doi: 10.1007/s11886-019-1107-y |
| SSID | ssj0023259 |
| Score | 2.40598 |
| SecondaryResourceType | review_article |
| Snippet | Arteriosclerosis and its sequelae are the most common cause of death in diabetic patients and one of the reasons why diabetes has entered the top 10 causes of... |
| SourceID | pubmedcentral cristin proquest crossref |
| SourceType | Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 10268 |
| SubjectTerms | Atherosclerosis Calcification Coronary vessels Diabetes Glucose Inflammation Insulin Review Tomography |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LaxsxEBZ5YMglNE1K3KRBhZJThCOtVo9eiil5FVJ6SMC3ZaXVUod47XTtg_99Z3ZlO3tILnvRsILRjOaTNPMNId-0KhM4dXEGoe6SSeUMMyaXLA8QbnMuebBYKHz_W90-yl-jdBQv3OqYVrnaE5uNuph6vCMfCAD2aQrWI3_MXhh2jcLX1dhCY5vsInUZpnTp0ebAlYimWRqHGMRUalXLsZnAMX8wfprUAG0MxFdkWe35xqWqbnTaQM5uwuSrCHT9gexH6EiH7VofkK1QfSS9tpnk8pDcDBHLTWsYg--4pm2FQk3HFY15LzW9R_7N-aL-TodrSk7qlvTP1QO9mzQdi47I4_XVw89bFtskMC-NmDOkxCuLNARRSp2WWHmqNHeAc7zRhfXaQkyWReGEDcobX5jSW6mRZ51bcNnkE9mpplU4xjynXOap5kLbIJ2T1olEudy4whsectcnx1FRWQUWiuyiqcisBdTXJxcrzWU-0otjl4tnEMpQ5VlH5X1yvhaftbwabwmerpYhi-5VZxtj6JOv62FwDHztyKswXTQyGstfDPxCd5ZvPSFSa3dHqvHfhmIbKXsU55_fn_yE7AmshsD3JXVKdub_FuELYJS5O2sM8T_Q2-R3 priority: 102 providerName: ProQuest |
| Title | Atherosclerosis Burdens in Diabetes Mellitus: Assessment by PET Imaging |
| URI | https://www.proquest.com/docview/2716557944 https://www.proquest.com/docview/2717686288 http://hdl.handle.net/10852/99405 https://pubmed.ncbi.nlm.nih.gov/PMC9499611 |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3fa9RAEB76A8EX0ar0anusID4ZdXP7UyhylrtW4UqRHtxbyG429Eqb0-YOvP_emSSXGmpf8rKThMzu5PuG3fkG4J1W-QCzLh4h1H2OhHImMiYVURoQblMueLBUKDw5V2dT8WMmZ_eSQo0Dy_-mdtRPanp38_HP7_VXDPhjyjgxZf80v74tkaYYxEpltmEXQUlTjE5Eu6GAvKHqm8YRjiIlrarlNh_ejjTYV9FVdIHqnn12z07-A0bj5_CsYZFsWE_7C9gqFnvwpO4ruX4Jp0OidYsSx_A6L1ldrFCyecGaIzAlm5AU53JVfmHDVp2TuTW7GF2y77dV86JXMB2PLk_OoqZjQuSFiZcRqePlmQwhzoWWORWhKs0dUh5vdGa9tgjPIstcbIPyxmcm91ZoklznFqN38Bp2ikUR9unIUypSqXmsbRDOCevigXKpcZk3PKSuB_uNo5ICFysJjco4sRYJYA8-bDyX-EZpnBpe3KBRQi5POi7vwfvW_FctsfGY4eFmGpLNQkliTPikxL-K6MHbdhhjhDY-0iIsVpWNpkoYg4_QnelrX0gq292RYn5VqW2Teo_i_ODx730DT2MqiqBtJnUIO8u7VThCqrJ0fdjWM41XMz7tw-630fnFzz6Bh-xXy_MvzaPpsQ |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF5VRRVcKp5qSoFFAk6sml2v91EJoQhaEtpUHFIpN-Ndr0UQddo6UZU_xW9kxo8EH-DWiy87sqXZmf1mvDPfEPJGqzyCrIszgLo-k8oZZkwqWRoAblMuebDYKDw-V8ML-XUaT7fI77YXBssq2zOxOqizucd_5IcCAvs4BuuRH6-uGU6NwtvVdoRGbRanYXULKVv5YfQZ9vetECfHk09D1kwVYF4asWDIIJdncQgilzrOsVFTae4gLPBGZ9ZrCxAms8wJG5Q3PjO5t1IjLTkk_AKnRMCRfw-At48epaebBC8S1XA2DpjHVGxVzekZRbZ_OPt5WUIoZQDPkdV1x1cuXHTRcBPidgs0_0K8k4dktwlV6aC2rUdkKxSPyU49vHL1hHwZYOw4L2ENnrOS1h0RJZ0VtKmzKekY-T4Xy_KIDtYUoNSt6LfjCR1dVhOSnpKLO1HgM7JdzIuwh3VVqUxjzYW2QTonrRORcqlxmTc8pK5H9hpFJQV4BLKZxiKxFqLMHnnfai7xDZ05TtX4BUIJqjzpqLxH3q3Fr2oej38JHrTbkDTuXCYb4-uR1-tlcES8XUmLMF9WMhrbbQy8Qne2b_1BpPLurhSzHxWlN1IEKc73___xV-T-cDI-S85G56fPyQOBnRh4t6UOyPbiZhleQHy0cC8ro6Tk-117wR-vvB-d |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqoiIuiKe6UMBIwAlra8dPJIRWtEuX0qqHVtpbiB1HXUSzhewK7V_j1zGTxy45wK2XXDxKpPGMZyae-T5CXhldJFB1cQahbp9J7S2zNpMsixBuMy55dDgofHKqjy7k56mabpHf3SwMtlV2Z2J9UOfzgP_IhwISe6XAeuSwaNsizg7GH65_MGSQwpvWjk6jMZHjuPoF5Vv1fnIAe_1aiPHh-ccj1jIMsCCtWDBEkytyFaMopFEFDm1qwz2kCMGa3AXjIJzJPPfCRR1syG0RnDQIUQ7Fv0DGCDj-b5lEcfQxM90Ue4moido4xD-mldMNvmeSuP3h7NtVBWmVhdiOCK87oXbnsh8ZN-luv1nzr-g3vkfutmkrHTV2dp9sxfIB2WmILFcPyacR5pHzCtbgOatoMx1R0VlJ256bip4g9udiWb2jozUcKPUrenZ4TidXNVvSI3JxIwp8TLbLeRl3sccqk5kyXBgXpffSeZFon1mfB8tj5gdkt1VUWoJ3ILKpEqlzkHEOyNtOc2looc2RYeM7CKWo8rSn8gF5sxa_bjA9_iW4121D2rp2lW4McUBerpfBKfGmJSvjfFnLGBy9sfAK09u-9QcR1ru_Us4ua3hvhAvSnD_5_8dfkNtg_-mXyenxU3JH4FAGXnPpPbK9-LmMzyBVWvjntU1S8vWmneAPCEMj0w |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Atherosclerosis+Burdens+in+Diabetes+Mellitus%3A+Assessment+by+PET+Imaging&rft.jtitle=International+journal+of+molecular+sciences&rft.au=H%C3%B8ilund-Carlsen%2C+Poul+F&rft.au=Piri%2C+Reza&rft.au=Madsen%2C+Per+Lav&rft.au=Rootwelt-Revheim%2C+Mona+Elisabeth&rft.date=2022-09-06&rft.issn=1661-6596&rft_id=info:doi/10.3390%2Fijms231810268&rft.externalDBID=n%2Fa&rft.externalDocID=10852_99405 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon |