Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus

• Published in: Synapse (New York, N.Y.) Vol. 60; no. 1; pp. 81 - 85
• Main Authors: Bonkale, Willy L., Turecki, Gustavo, Austin, Mark C.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2006
• Subjects: Adult; alcohol dependence; Alcoholism - complications; Alcoholism - metabolism; Alcoholism - psychology; Autoradiography; brainstem; Depression - complications; Depression - metabolism; Depression - psychology; Female; human; Humans; immunoautoradiography; Immunohistochemistry; Male; Middle Aged; mood disorders; postmortem; Raphe Nuclei - metabolism; Suicide - psychology; Tryptophan Hydroxylase - metabolism

Considerable evidence suggests that alcoholics with co‐occurring depressive disorder are at greater risk for developing psychosocial problems particularly suicidal behavior. Moreover, dysfunction in serotonin (5‐HT) neurotransmission has been implicated in depression, suicide and alcoholism. In the...