Long-term pattern of brain natriuretic peptide and N-terminal pro brain natriuretic peptide and its determinants in the general population: contribution of age, gender, and cardiac and extra-cardiac factors

• Published in: European journal of heart failure Vol. 15; no. 8; pp. 859 - 867
• Main Authors: Luchner, Andreas, Behrens, Gundula, Stritzke, Jan, Markus, Marcello, Stark, Klaus, Peters, Annette, Meisinger, Christa, Leitzmann, Michael, Hense, Hans-Werner, Schunkert, Heribert, Heid, Iris M.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2013
• Subjects: 10-year-follow-up; Adrenergic beta-Antagonists - therapeutic use; Adult; Aged; Aging - blood; Biomarkers - blood; Body Mass Index; Cohort Studies; Diabetes Mellitus - blood; Diabetes Mellitus - epidemiology; Echocardiography; Female; Germany - epidemiology; Heart Atria - diagnostic imaging; Heart failure; Heart Ventricles - diagnostic imaging; Humans; Hypertension; Hypertrophy, Left Ventricular - blood; Hypertrophy, Left Ventricular - epidemiology; Longitudinal Studies; LV hypertrophy; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction - blood; Myocardial Infarction - epidemiology; Natriuretic Peptide, Brain - blood; Natriuretic peptides; Organ Size; Peptide Fragments - blood; Regression Analysis; Sex Factors; Heart failure; Hypertension; Echocardiography; LV hypertrophy; 10-year-follow-up; Natriuretic peptides

Aims The natriuretic peptides BNP and NT‐proBNP are potent cardiac markers, but knowledge of long‐term changes is sparse. We thus quantified determinants of change in BNP and NT‐proBNP in a study of south German residents (KORA). Methods and results A total of 1005 men and women (age 25–74 years, me...