Antidepressant Effect of Intracerebroventricularly Administered Deltorphin Analogs in the Mouse Tail Suspension Test
Several studies have proposed δ opioid receptors as influential targets for developing novel antidepressants. Deltorphin (DLT) and deltorphin II (DLT-II) have high affinity and selectivity for δ opioid receptors; thus, it is likely that DLT analogs possess antidepressant-like effects. Based on this,...
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| Published in | Biological & pharmaceutical bulletin Vol. 45; no. 4; pp. 538 - 541 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Japan
The Pharmaceutical Society of Japan
01.04.2022
Japan Science and Technology Agency |
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| Abstract | Several studies have proposed δ opioid receptors as influential targets for developing novel antidepressants. Deltorphin (DLT) and deltorphin II (DLT-II) have high affinity and selectivity for δ opioid receptors; thus, it is likely that DLT analogs possess antidepressant-like effects. Based on this, we evaluated the effects of four DLT analogs (DLT-related synthetic peptides) on immobility behavior in the tail suspension test. Intracerebroventricular administration of DLT or [N-isobutyl-Gly6]DLT in mice significantly decreased immobile behavior. However, administration of DLT did not affect locomotor activity, whereas that of [N-isobutyl-Gly6]DLT significantly increased locomotion in mice. The effect of the shortened immobility time following DLT administration was counteracted by the administration of the selective δ1 opioid receptor antagonist 7-benzylidenenaltrexone, but not by the selective δ2 opioid receptor antagonist naltriben. These findings suggest that DLT has an antidepressant-like effect by activating the central δ1 opioid receptor in mice. |
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| AbstractList | Several studies have proposed δ opioid receptors as influential targets for developing novel antidepressants. Deltorphin (DLT) and deltorphin II (DLT-II) have high affinity and selectivity for δ opioid receptors; thus, it is likely that DLT analogs possess antidepressant-like effects. Based on this, we evaluated the effects of four DLT analogs (DLT-related synthetic peptides) on immobility behavior in the tail suspension test. Intracerebroventricular administration of DLT or [N-isobutyl-Gly6]DLT in mice significantly decreased immobile behavior. However, administration of DLT did not affect locomotor activity, whereas that of [N-isobutyl-Gly6]DLT significantly increased locomotion in mice. The effect of the shortened immobility time following DLT administration was counteracted by the administration of the selective δ1 opioid receptor antagonist 7-benzylidenenaltrexone, but not by the selective δ2 opioid receptor antagonist naltriben. These findings suggest that DLT has an antidepressant-like effect by activating the central δ1 opioid receptor in mice. Several studies have proposed δ opioid receptors as influential targets for developing novel antidepressants. Deltorphin (DLT) and deltorphin II (DLT-II) have high affinity and selectivity for δ opioid receptors; thus, it is likely that DLT analogs possess antidepressant-like effects. Based on this, we evaluated the effects of four DLT analogs (DLT-related synthetic peptides) on immobility behavior in the tail suspension test. Intracerebroventricular administration of DLT or [N-isobutyl-Gly ]DLT in mice significantly decreased immobile behavior. However, administration of DLT did not affect locomotor activity, whereas that of [N-isobutyl-Gly ]DLT significantly increased locomotion in mice. The effect of the shortened immobility time following DLT administration was counteracted by the administration of the selective δ opioid receptor antagonist 7-benzylidenenaltrexone, but not by the selective δ opioid receptor antagonist naltriben. These findings suggest that DLT has an antidepressant-like effect by activating the central δ opioid receptor in mice. |
| ArticleNumber | b21-01078 |
| Author | Nemoto, Wataru Tan-No, Koichi Nakagawasai, Osamu Takahashi, Kohei Ambo, Akihiro Takahashi, Naruya Onuma, Kentaro |
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| Cites_doi | 10.1016/j.brainres.2005.11.005 10.1016/j.jff.2020.104312 10.1073/pnas.86.13.5188 10.1016/j.brainres.2007.07.095 10.1016/0014-2999(89)90611-0 10.1002/cne.20378 10.1016/0024-3205(93)90240-4 10.1007/s00213-016-4224-y 10.1016/j.neuropharm.2018.04.013 10.1016/j.jphs.2018.06.006 10.1016/S0014-2999(98)00268-4 10.1016/S0893-133X(01)00413-4 10.1097/00008877-200311000-00003 10.1016/j.bbr.2011.04.041 10.1016/j.bbr.2016.11.008 10.1097/00001756-199809140-00028 10.1152/physrev.00005.2009 10.1073/pnas.89.24.12048 10.1111/bph.12852 10.1016/j.neuropharm.2012.01.005 10.1016/S0024-3205(96)00508-5 10.1016/0024-3205(96)00307-4 10.1254/jphs.FPJ04014X 10.1016/0024-3205(93)90062-8 10.1016/S0006-291X(05)81138-6 10.1126/science.1335167 |
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| SubjectTerms | Animals antidepressant Antidepressants Antidepressive Agents - pharmacology deltorphin Deltorphin II Hindlimb Suspension Intracerebroventricular administration Locomotion Locomotor activity Mice Narcotic Antagonists - pharmacology Narcotics Oligopeptides Opioid receptors Receptors, Opioid, delta Synthetic peptides δ1 receptor |
| Title | Antidepressant Effect of Intracerebroventricularly Administered Deltorphin Analogs in the Mouse Tail Suspension Test |
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