Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP

• Published in: British journal of pharmacology Vol. 166; no. 6; pp. 1793 - 1803
• Main Authors: Kusuhara, Hiroyuki, Furuie, Hidetoshi, Inano, Akihiro, Sunagawa, Akihiro, Yamada, Saiko, Wu, Chunyong, Fukizawa, Shinya, Morimoto, Nozomi, Ieiri, Ichiro, Morishita, Mariko, Sumita, Kiminobu, Mayahara, Hiroshi, Fujita, Takuya, Maeda, Kazuya, Sugiyama, Yuichi
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2012; Nature Publishing Group
• Subjects: Animals; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - antagonists & inhibitors; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; BCRP; Biological and medical sciences; Biological Availability; curcumin; Curcumin - pharmacology; DNA, Complementary - genetics; drug absorption; Female; HEK293 Cells; Humans; in vivo inhibitor; Male; Medical sciences; Mice; Mice, Knockout; microdosing; non‐linear pharmacokinetics; Organic Anion Transporters - genetics; pharmacokinetic interaction; Pharmacology. Drug treatments; Research Papers; Sulfasalazine - blood; Sulfasalazine - pharmacokinetics; sulphasalazine; Transfection; Human; Drug; BCRP; pharmacokinetic interaction; Healthy subject; Tyrosine kinase inhibitor; Interaction; in vivo inhibitor; Antiinflammatory agent; sulphasalazine; In vivo; Absorption; non-linear pharmacokinetics; Sulfonamides; microdosing; Sulfasalazine; Curcumin; drug absorption; Salicylates; Pharmacokinetics

BACKGROUND AND PURPOSE An ATP‐binding cassette (ABC) transporter, breast cancer resistance protein (BCRP)/ABCG2, limits oral bioavailability of sulphasalazine. Here we examined the effect of curcumin, the principal curcuminoid of turmeric, on oral bioavailability of microdoses and therapeutic doses...