Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP - Kusuhara, Hiroyuki; Furuie, Hidetoshi; Inano, Akihiro; Sunagawa, Akihiro; Yamada, Saiko; Wu, Chunyong; Fukizawa, Shinya; Morimoto, Nozomi; Ieiri, Ichiro; Morishita, Mariko; Sumita, Kiminobu; Mayahara, Hiroshi; et al. (British journal of pharmacology, 2012)
Keywords: Animals; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - antagonists & inhibitors; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; BCRP; Biological and medical sciences; Biological Availability; curcumin; Curcumin - pharmacology; DNA, Complementary - genetics; drug absorption; Female; HEK293 Cells; Humans; in vivo inhibitor; Male; Medical sciences; Mice; Mice, Knockout; microdosing; non‐linear pharmacokinetics; Organic Anion Transporters - genetics; pharmacokinetic interaction; Pharmacology. Drug treatments; Research Papers; Sulfasalazine - blood; Sulfasalazine - pharmacokinetics; sulphasalazine; Transfection; Human; Drug; BCRP; pharmacokinetic interaction; Healthy subject; Tyrosine kinase inhibitor; Interaction; in vivo inhibitor; Antiinflammatory agent; sulphasalazine; In vivo; Absorption; non-linear pharmacokinetics; Sulfonamides; microdosing; Sulfasalazine; Curcumin; drug absorption; Salicylates; Pharmacokinetics