Preoperative Vitamin D Deficiency Predicts Postoperative Hypocalcemia After Total Thyroidectomy
Background Transient postthyroidectomy hypocalcemia occurs in up to 30% of patients. We evaluated the effect of vitamin D deficiency on postthyroidectomy hypocalcemia. Methods Data were collected prospectively between January 2006 and March 2009. A total of 166 consecutive total thyroidectomies were...
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Published in | World journal of surgery Vol. 35; no. 2; pp. 324 - 330 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer-Verlag
01.02.2011
Springer‐Verlag Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Transient postthyroidectomy hypocalcemia occurs in up to 30% of patients. We evaluated the effect of vitamin D deficiency on postthyroidectomy hypocalcemia.
Methods
Data were collected prospectively between January 2006 and March 2009. A total of 166 consecutive total thyroidectomies were analyzed regarding the relation between preoperative vitamin D
3
levels and postoperative corrected calcium levels. Patients were divided into three groups dependent upon the preoperative vitamin D
3
level: group 1, <25 nmol/l; group 2, 25–50 nmol/l; group 3, >50 nmol/l (conversion factor of 2.5× between nanomoles per liter and nanograms per milliliter). Hypocalcemia was defined as a postoperative calcium level <2.00 mmol/l (8 mg/dl). Hospital length of stay was recorded.
Results
There was a difference in postoperative hypocalcemia between the three vitamin D
3
groups (group 1 (32%) vs. group 2 (24%) vs. group 3 (13%). Hypocalcemia in group 1 (vit D <25 nmol/l, <10 ng/ml) was significantly more likely than in group 3 (vit D >50 nmol/l, >20 ng/ml) (
P
= 0.025, χ
2
test. Vitamin D
3
deficiency was also associated with a longer hospital stay (median stay 2 days vs. 1 day,
P
< 0.001, Wilcoxon rank test).
Conclusions
There is a significant difference in postoperative hypocalcemia rates between those with vitamin D levels >50 nmol/l (>20 ng/ml) and those with a level of <25 nmol/l (<10 ng/ml). Vitamin D deficiency leads to a delay in discharge owing to a higher likelihood of hypocalcemia. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0364-2313 1432-2323 |
DOI: | 10.1007/s00268-010-0872-y |