Generation and Characterization of Novel Pan‐Cancer Anti‐uPAR Fluorescent Nanobodies as Tools for Image‐Guided Surgery

• Published in: Advanced science Vol. 11; no. 30; pp. e2400700 - n/a
• Main Authors: Mateusiak, Łukasz, Floru, Sam, De Groof, Timo W. M., Wouters, Janne, Declerck, Noemi B., Debie, Pieterjan, Janssen, Simone, Zeven, Katty, Puttemans, Janik, Vincke, Cécile, Breckpot, Karine, Devoogdt, Nick, Hernot, Sophie
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2024; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Biodistribution; Breast cancer; Camelids, New World; Cancer therapies; Cell Line, Tumor; Clinical trials; Cloning; Colorectal cancer; Contrast agents; Disease Models, Animal; fluorescence molecular imaging; fluorescence‐guided surgery; Fluorescent Dyes; Glioma; Humans; Lungs; Mice; Neoplasms - diagnostic imaging; Neoplasms - immunology; Neoplasms - surgery; Optical Imaging - methods; Receptors, Urokinase Plasminogen Activator - metabolism; Single-Domain Antibodies - immunology; single‐domain antibodies; Surgery; Surgery, Computer-Assisted - methods; Tumors; urokinase plasminogen activator receptor; single‐domain antibodies; fluorescence‐guided surgery; fluorescence molecular imaging; urokinase plasminogen activator receptor

Fluorescence molecular imaging plays a vital role in image‐guided surgery. In this context, the urokinase plasminogen activator receptor (uPAR) is an interesting biomarker enabling the detection and delineation of various tumor types due to its elevated expression on both tumor cells and the tumor m...