Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease

• Published in: Hippocampus Vol. 29; no. 5; pp. 422 - 439
• Main Authors: Ginsberg, Stephen D., Malek‐Ahmadi, Michael H., Alldred, Melissa J., Che, Shaoli, Elarova, Irina, Chen, Yinghua, Jeanneteau, Freddy, Kranz, Thorsten M., Chao, Moses V, Counts, Scott E., Mufson, Elliott J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2019; Wiley
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; brain‐derived neurotrophic factor; CA1 Region, Hippocampal - metabolism; CA1 Region, Hippocampal - pathology; Cognitive ability; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Complications; Degeneration; Dementia disorders; Disease Progression; Dissection; DNA microarrays; Female; Gene expression; Glial cell line-derived neurotrophic factor; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Humans; Life Sciences; Male; Memory; microarray; Nerve growth factor; Nerve Growth Factors - metabolism; neuritic plaques; Neurodegenerative diseases; Neurofibrillary tangles; Neuropathology; Neurotrophic factors; Pyramidal cells; Pyramidal Cells - metabolism; Pyramidal Cells - pathology; Receptors, Nerve Growth Factor - metabolism; Senile plaques; Short term memory; Spatial memory; Temporal lobe; Trk receptors; TrkA protein; TrkA receptors; TrkB receptors; microarray; brain-derived neurotrophic factor; Trk receptors; neurofibrillary tangles; neuritic plaques

Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe memory circuit, are selectively vulnerable during the progression of Alzheimer's disease (AD). The cellular mechanism(s) underlying degeneration of these neurons and the relationship to cognitive performance remain...