Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development

• Published in: Advanced science Vol. 11; no. 29; pp. e2308556 - n/a
• Main Authors: Wang, Gang, Wu, Hangdi, Zhai, Xiuwen, Zhang, Li, Zhang, Changming, Cheng, Chen, Xu, Xiaodong, Gao, Erzhi, Xiong, Xushen, Zhang, Jin, Liu, Zhihong
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.08.2024; John Wiley and Sons Inc; Wiley
• Subjects: Binding sites; Cells; Gene expression; Genotype & phenotype; Humans; Induced Pluripotent Stem Cells - metabolism; Kidney - metabolism; kidney organoid; Kidneys; Mutation; Mutation - genetics; Organoids - metabolism; podocyte development; Podocytes - metabolism; scATAC‐seq; scRNA‐seq; WT1; WT1 Proteins - genetics; WT1 Proteins - metabolism; scRNA‐seq; scATAC‐seq; podocyte development; kidney organoid; WT1

Wilms tumor‐1(WT1) is a crucial transcription factor that regulates podocyte development. However, the epigenomic mechanism underlying the function of WT1 during podocyte development has yet to be fully elucidated. Here, single‐cell chromatin accessibility and gene expression maps of foetal kidneys...