Determination of the effect of functional single-nucleotide polymorphisms associated with glycerolipid synthesis on intramuscular fat deposition in Korean cattle steer
Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on the mitochondrial outer mem...
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| Published in | Archiv für Tierzucht Vol. 64; no. 1; pp. 27 - 33 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Gottingen
Copernicus GmbH
19.01.2021
Copernicus Publications |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2363-9822 0003-9438 2363-9822 |
| DOI | 10.5194/aab-64-27-2021 |
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| Abstract | Intramuscular fat deposition in the longissimus dorsi
muscle (LM) of Korean cattle steer is regulated by several genes related to
lipid metabolism. One of these genes encodes the enzyme bovine
glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on
the mitochondrial outer membrane and catalyzes the initial and committed
step of glycerolipid synthesis in lipid metabolism of cattle. Previous
studies have shown that the 3′-untranslated region (UTR) of the
GPAM is quite extended and contains a polyadenylation signal site, erythroid
15-lipoxygenase differentiation control elements (15-LOX-DICEs), and
cytoplasmic polyadenylation elements (CPEs) that affect the regulation of
triacylglycerol synthesis. Therefore, the aim of this study was to
identify single-nucleotide polymorphisms (SNPs) related to the regulation of
glycerolipid synthesis in the 3′-UTR of GPAM and to verify the function
of SNPs affecting the deposition of intramuscular fat in Korean cattle
steer. In the present study, 11 SNPs were discovered in the 3′-UTR
of GPAM. Among these SNPs, g.54853A>G, g.55441A>G, and
g.55930C>T were significantly associated with marbling score in
a Korean cattle steer population and were strongly correlated with each other
within the GPAM gene. Furthermore, based on the results predicted by the
RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the
above SNPs were found to present in the seed region of these miRNAs. These
miRNAs have a differential binding affinity for each allele of SNPs
g.54853A>G, g.55441A>G, and g.55930C>T.
The in vivo evidence of intramuscular fat deposition in the LM tissue showed that
these SNPs affected the regulation of intramuscular fat deposition in Korean
cattle steer. Thus, the g.54853A>G, g.55441A>G, and
g.55930C>T could be considered as causal mutations regulating
intramuscular fat deposition in Korean cattle steer. |
|---|---|
| AbstractList | Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3.sup.' -untranslated region (UTR) of the GPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3.sup.' -UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3.sup.' -UTR of GPAM. Among these SNPs, g.54853AG, g.55441AG, and g.55930CT were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853AG, g.55441AG, and g.55930CT. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853AG, g.55441AG, and g.55930CT could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer. Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3 ′ -untranslated region (UTR) of the GPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3 ′ -UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3 ′ -UTR of GPAM. Among these SNPs, g.54853A > G, g.55441A > G, and g.55930C > T were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853A > G, g.55441A > G, and g.55930C > T. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853A > G, g.55441A > G, and g.55930C > T could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer. Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial ( GPAM ), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3 ′ -untranslated region (UTR) of the GPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3 ′ -UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3 ′ -UTR of GPAM . Among these SNPs, g.54853A > G, g.55441A > G, and g.55930C > T were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853A > G, g.55441A > G, and g.55930C > T. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853A > G, g.55441A > G, and g.55930C > T could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer. Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3 ' -untranslated region (UTR) of the GPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3 ' -UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3 ' -UTR of GPAM. Among these SNPs, g.54853A > G, g.55441A > G, and g.55930C > T were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853A > G, g.55441A > G, and g.55930C > T. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853A > G, g.55441A > G, and g.55930C > T could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer.Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3 ' -untranslated region (UTR) of the GPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3 ' -UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3 ' -UTR of GPAM. Among these SNPs, g.54853A > G, g.55441A > G, and g.55930C > T were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853A > G, g.55441A > G, and g.55930C > T. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853A > G, g.55441A > G, and g.55930C > T could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer. Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial ( GPAM), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3 ′ -untranslated region (UTR) of the GPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3 ′ -UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3 ′ -UTR of GPAM. Among these SNPs, g.54853A > G, g.55441A > G, and g.55930C > T were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853A > G, g.55441A > G, and g.55930C > T. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853A > G, g.55441A > G, and g.55930C > T could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer. Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3′-untranslated region (UTR) of the GPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3′-UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3′-UTR of GPAM. Among these SNPs, g.54853A>G, g.55441A>G, and g.55930C>T were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853A>G, g.55441A>G, and g.55930C>T. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853A>G, g.55441A>G, and g.55930C>T could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer. Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of these genes encodes the enzyme bovine glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), which is located on the mitochondrial outer membrane and catalyzes the initial and committed step of glycerolipid synthesis in lipid metabolism of cattle. Previous studies have shown that the 3′-untranslated region (UTR) of theGPAM is quite extended and contains a polyadenylation signal site, erythroid 15-lipoxygenase differentiation control elements (15-LOX-DICEs), and cytoplasmic polyadenylation elements (CPEs) that affect the regulation of triacylglycerol synthesis. Therefore, the aim of this study was to identify single-nucleotide polymorphisms (SNPs) related to the regulation of glycerolipid synthesis in the 3′-UTR of GPAM and to verify the function of SNPs affecting the deposition of intramuscular fat in Korean cattle steer. In the present study, 11 SNPs were discovered in the 3′-UTR of GPAM. Among these SNPs, g.54853A>G, g.55441A>G, and g.55930C>T were significantly associated with marbling score in a Korean cattle steer population and were strongly correlated with each other within the GPAM gene. Furthermore, based on the results predicted by the RNAhybrid program, four putative microRNAs (miRNAs) were identified, and the above SNPs were found to present in the seed region of these miRNAs. These miRNAs have a differential binding affinity for each allele of SNPs g.54853A>G, g.55441A>G, and g.55930C>T. The in vivo evidence of intramuscular fat deposition in the LM tissue showed that these SNPs affected the regulation of intramuscular fat deposition in Korean cattle steer. Thus, the g.54853A>G, g.55441A>G, and g.55930C>T could be considered as causal mutations regulating intramuscular fat deposition in Korean cattle steer. |
| Audience | Academic |
| Author | Kim, Hyeongrok Oh, Dong-Yep Lee, Yoonseok |
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| Cites_doi | 10.1016/j.gene.2017.01.031 10.5187/JAST.2008.50.3.293 10.1159/000087517 10.1371/journal.pone.0036694 10.1002/em.22159 10.1007/s11033-010-0550-z 10.2527/jas.2011-4753 10.1093/bioinformatics/bts623 10.1016/j.cell.2009.01.002 10.1007/s13258-017-0634-4 10.1016/j.ygeno.2012.08.006 10.5713/ajas.2010.10113 10.1038/nrg1379 |
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| Copyright | COPYRIGHT 2021 Copernicus GmbH 2021. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright: © 2021 Hyeongrok Kim et al. Copyright: © 2021 Hyeongrok Kim et al. 2021 |
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| Snippet | Intramuscular fat deposition in the longissimus dorsi
muscle (LM) of Korean cattle steer is regulated by several genes related to
lipid metabolism. One of... Intramuscular fat deposition in the longissimus dorsi muscle (LM) of Korean cattle steer is regulated by several genes related to lipid metabolism. One of... |
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| StartPage | 27 |
| SubjectTerms | 3' Untranslated regions Acyltransferase alleles arachidonate 15-lipoxygenase Beef Beef cattle Biosynthesis Cattle Deoxyribonucleic acid Deposition DNA Enzymes Generalized linear models Genes Genetic aspects Glycerol Glycerol-3-phosphate glycerol-3-phosphate acyltransferase intramuscular fat Laws, regulations and rules Lipid metabolism Lipids Lipoxygenase Liquid oxygen longissimus muscle marbling Metabolism microRNA MicroRNAs miRNA Mitochondria Muscles Mutation Nucleotides Original Study Physiological aspects Polyadenylation Single nucleotide polymorphisms Single-nucleotide polymorphism steers triacylglycerols Triglycerides |
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| Title | Determination of the effect of functional single-nucleotide polymorphisms associated with glycerolipid synthesis on intramuscular fat deposition in Korean cattle steer |
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