P029 Pharmacokinetic/Pharmacodynamic Analysis of Amiselimod, a Selective Sphingosine 1-Phosphate Receptor Modulator, in Healthy Subjects: Results From a Phase 1 Study

• Published in: The American journal of gastroenterology Vol. 116; no. Suppl 1; p. S7
• Main Authors: Lee, Jimin, Lester, Robert, O'Reilly, Terry, Lowe, Ezra, Slatkin, Neal, Franklin, Howard, Israel, Robert
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.12.2021; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Gastroenterology; Pharmacodynamics; Pharmacokinetics

Amiselimod is a selective sphingosine 1-phosphate receptor modulator in development for inflammatory bowel disease. It is converted to its active metabolite, amiselimod phosphate (amiselimod-P), and has a long half-life and slow accumulation to steady state. We evaluated a multiple-dose titration re...