Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018
Chronic thromboembolic pulmonary hypertension (CTEPH) is a subgroup of pulmonary hypertension that differs from all other forms of PH in terms of its pathophysiology, patient characteristics and treatment. For implementation of the European Guidelines on Diagnosis and Treatment of Pulmonary Hyperten...
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| Published in | International journal of cardiology Vol. 272; pp. 69 - 78 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.12.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Chronic thromboembolic pulmonary hypertension (CTEPH) is a subgroup of pulmonary hypertension that differs from all other forms of PH in terms of its pathophysiology, patient characteristics and treatment. For implementation of the European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension in Germany, the Cologne Consensus Conference 2016 was held and last updated in spring of 2018. One of the working groups was dedicated to CTEPH, practical and controversial issues were commented and updated. In every patient with suspected PH, CTEPH or chronic thromboembolic disease (CTED, i.e. symptomatic residual vasculopathy without pulmonary hypertension) should be excluded. Primary treatment is surgical pulmonary endarterectomy (PEA) in a multidisciplinary CTEPH centre. Inoperable patients or patients with persistent or recurrent CTEPH after PEA are candidates for targeted drug therapy. There is increasing experience with balloon pulmonary angioplasty (BPA) for inoperable patients; this option, like PEA, is reserved for specialised centres with expertise in this treatment method. |
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| AbstractList | Chronic thromboembolic pulmonary hypertension (CTEPH) is a subgroup of pulmonary hypertension that differs from all other forms of PH in terms of its pathophysiology, patient characteristics and treatment. For implementation of the European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension in Germany, the Cologne Consensus Conference 2016 was held and last updated in spring of 2018. One of the working groups was dedicated to CTEPH, practical and controversial issues were commented and updated. In every patient with suspected PH, CTEPH or chronic thromboembolic disease (CTED, i.e. symptomatic residual vasculopathy without pulmonary hypertension) should be excluded. Primary treatment is surgical pulmonary endarterectomy (PEA) in a multidisciplinary CTEPH centre. Inoperable patients or patients with persistent or recurrent CTEPH after PEA are candidates for targeted drug therapy. There is increasing experience with balloon pulmonary angioplasty (BPA) for inoperable patients; this option, like PEA, is reserved for specialised centres with expertise in this treatment method.Chronic thromboembolic pulmonary hypertension (CTEPH) is a subgroup of pulmonary hypertension that differs from all other forms of PH in terms of its pathophysiology, patient characteristics and treatment. For implementation of the European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension in Germany, the Cologne Consensus Conference 2016 was held and last updated in spring of 2018. One of the working groups was dedicated to CTEPH, practical and controversial issues were commented and updated. In every patient with suspected PH, CTEPH or chronic thromboembolic disease (CTED, i.e. symptomatic residual vasculopathy without pulmonary hypertension) should be excluded. Primary treatment is surgical pulmonary endarterectomy (PEA) in a multidisciplinary CTEPH centre. Inoperable patients or patients with persistent or recurrent CTEPH after PEA are candidates for targeted drug therapy. There is increasing experience with balloon pulmonary angioplasty (BPA) for inoperable patients; this option, like PEA, is reserved for specialised centres with expertise in this treatment method. Chronic thromboembolic pulmonary hypertension (CTEPH) is a subgroup of pulmonary hypertension that differs from all other forms of PH in terms of its pathophysiology, patient characteristics and treatment. For implementation of the European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension in Germany, the Cologne Consensus Conference 2016 was held and last updated in spring of 2018. One of the working groups was dedicated to CTEPH, practical and controversial issues were commented and updated. In every patient with suspected PH, CTEPH or chronic thromboembolic disease (CTED, i.e. symptomatic residual vasculopathy without pulmonary hypertension) should be excluded. Primary treatment is surgical pulmonary endarterectomy (PEA) in a multidisciplinary CTEPH centre. Inoperable patients or patients with persistent or recurrent CTEPH after PEA are candidates for targeted drug therapy. There is increasing experience with balloon pulmonary angioplasty (BPA) for inoperable patients; this option, like PEA, is reserved for specialised centres with expertise in this treatment method. |
| Author | Ulrich, Silvia Klepetko, Walter Hinrichs, Jan B. Lang, Irene M. Gerhardt, Felix Olsson, Karen M. Schmidt, Matthias Grgic, Aleksandar Guth, Stefan Hoeper, Marius M. Meyer, Bernhard C. Mayer, Eckhard Schäfers, Hans-Joachim Seyfarth, Hans-J Krüger, Ulrich Held, Matthias Wiedenroth, Christoph B. Konstantinides, Stavros Lankeit, Mareike Bunck, Alexander C. Grohé, Christian Kramm, Thorsten Wilkens, Heinrike Gerges, Mario |
| Author_xml | – sequence: 1 givenname: Heinrike surname: Wilkens fullname: Wilkens, Heinrike email: heinrike.wilkens@uks.eu organization: Department of Internal Medicine V – Pneumology, Allergology and Critical Care Medicine, University Hospital of Saarland, 66421 Homburg, Saar, Germany – sequence: 2 givenname: Stavros surname: Konstantinides fullname: Konstantinides, Stavros organization: Centrum für Thrombose und Hämostase (CTH), Universitätsmedizin der Johannes-Gutenberg Universität Mainz, Langenbeckstr. 1, 55131 Mainz, Germany – sequence: 3 givenname: Irene M. surname: Lang fullname: Lang, Irene M. organization: Klinik für Innere Medizin II, Abt. Kardiologie, Medizinische Universität Wien, Austria – sequence: 4 givenname: Alexander C. surname: Bunck fullname: Bunck, Alexander C. organization: Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinik Köln, Germany – sequence: 5 givenname: Mario surname: Gerges fullname: Gerges, Mario organization: Klinik für Innere Medizin II, Abt. Kardiologie, Medizinische Universität Wien, Austria – sequence: 6 givenname: Felix surname: Gerhardt fullname: Gerhardt, Felix organization: Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinik Köln, Germany – sequence: 7 givenname: Aleksandar surname: Grgic fullname: Grgic, Aleksandar organization: Radiologische Praxis Homburg, 66424 Homburg, Germany – sequence: 8 givenname: Christian surname: Grohé fullname: Grohé, Christian organization: Klinik für Pneumologie Evangelische Lungenklinik Berlin, Buch, 13125 Berlin, Germany – sequence: 9 givenname: Stefan surname: Guth fullname: Guth, Stefan organization: Department of Thoracic Surgery, Kerckhoff-Clinic GmbH, Benekestr. 2-8, 61231 Bad Nauheim, Germany – sequence: 10 givenname: Matthias surname: Held fullname: Held, Matthias organization: Missionsärztliche Klinik Würzburg, Innere Medizin, Pneumologie/Kardiologie, Zentrum für pulmonale Hyertonie und Lungengefäßkrankheiten, Germany – sequence: 11 givenname: Jan B. surname: Hinrichs fullname: Hinrichs, Jan B. organization: Institut für Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Germany – sequence: 12 givenname: Marius M. surname: Hoeper fullname: Hoeper, Marius M. organization: Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany – sequence: 13 givenname: Walter surname: Klepetko fullname: Klepetko, Walter organization: Klinische Abteilung für Thoraxchirurgie, Medizinische Universität Wien, Austria – sequence: 14 givenname: Thorsten surname: Kramm fullname: Kramm, Thorsten organization: Department of Thoracic Surgery, Kerckhoff-Clinic GmbH, Benekestr. 2-8, 61231 Bad Nauheim, Germany – sequence: 15 givenname: Ulrich surname: Krüger fullname: Krüger, Ulrich organization: Klinik für Kardiologie und Angiologie, Herzzentrum Duisburg, Germany – sequence: 16 givenname: Mareike surname: Lankeit fullname: Lankeit, Mareike organization: Medizinische Klinik mit Schwerpunkt Kardiologie, Campus Virchow Klinikum, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany – sequence: 17 givenname: Bernhard C. surname: Meyer fullname: Meyer, Bernhard C. organization: Institut für Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Germany – sequence: 18 givenname: Karen M. surname: Olsson fullname: Olsson, Karen M. organization: Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany – sequence: 19 givenname: Hans-Joachim surname: Schäfers fullname: Schäfers, Hans-Joachim organization: Klinik für Thorax-Herz-Gefäßchirurgie, Universitätsklinikum des Saarlandes, 66421 Homburg, Germany – sequence: 20 givenname: Matthias surname: Schmidt fullname: Schmidt, Matthias organization: Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Köln, 50937 Köln, Germany – sequence: 21 givenname: Hans-J surname: Seyfarth fullname: Seyfarth, Hans-J organization: Abteilung Pneumologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig, Germany – sequence: 22 givenname: Silvia surname: Ulrich fullname: Ulrich, Silvia organization: Clinic of Pulmonology, University Hospital of Zurich, Switzerland – sequence: 23 givenname: Christoph B. surname: Wiedenroth fullname: Wiedenroth, Christoph B. organization: Department of Thoracic Surgery, Kerckhoff-Clinic GmbH, Benekestr. 2-8, 61231 Bad Nauheim, Germany – sequence: 24 givenname: Eckhard surname: Mayer fullname: Mayer, Eckhard organization: Department of Thoracic Surgery, Kerckhoff-Clinic GmbH, Benekestr. 2-8, 61231 Bad Nauheim, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30195840$$D View this record in MEDLINE/PubMed |
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| Keywords | Chronic thromboembolic pulmonary hypertension Pulmonary endarterectomy Chronic thromboembolic disease Medical therapy Balloon pulmonary angioplasty |
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| SubjectTerms | Balloon pulmonary angioplasty Chronic thromboembolic disease Chronic thromboembolic pulmonary hypertension Medical therapy Pulmonary endarterectomy |
| Title | Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018 |
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