dNAGLU Extends Life Span and Promotes Fitness and Stress Resistance in Drosophila
To identify new factors that promote longevity and healthy aging, we studied , an ortholog of the human gene, a lysosomal enzyme overexpressed in centenarians. We found that the overexpression of ( ) ubiquitously, or tissue specifically, in the nervous system or fat body could extend fly life span....
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Published in | International journal of molecular sciences Vol. 23; no. 22; p. 14433 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Abstract | To identify new factors that promote longevity and healthy aging, we studied
, an ortholog of the human
gene, a lysosomal enzyme overexpressed in centenarians. We found that the overexpression of
(
) ubiquitously, or tissue specifically, in the nervous system or fat body could extend fly life span. It also extended the life span of flies overexpressing human Aβ42, in a
Alzheimer's disease (AD) model. To investigate whether
could influence health span, we analyzed the effect of its overexpression on AD flies and found that it improved the climbing ability and stress resistance, including desiccation and hunger, suggesting that
improved fly health span. We found that the deposition of Aβ42 in the mushroom body, which is the fly central nervous system, was reduced, and the lysosomal activity in the intestine was increased in
over-expressing flies. When
was overexpressed in human U251-APP cells, which expresses a mutant form of the Aβ-precursor protein (APP), APP-p.M671L, these cells exhibited stronger lysosomal activity and and enhanced expression of lysosomal pathway genes. The concentration of Aβ42 in the cell supernatant was reduced, and the growth arrest caused by APP expression was reversed, suggesting that
could play a wider role beyond its catalytic activity to enhance lysosomal activity. These results also suggest that
overexpression could be explored to promote healthy aging and to prevent the onset of neurodegenerative diseases, including AD. |
---|---|
AbstractList | To identify new factors that promote longevity and healthy aging, we studied Drosophila CG13397, an ortholog of the human NAGLU gene, a lysosomal enzyme overexpressed in centenarians. We found that the overexpression of CG13397 (dNAGLU) ubiquitously, or tissue specifically, in the nervous system or fat body could extend fly life span. It also extended the life span of flies overexpressing human Aβ42, in a Drosophila Alzheimer’s disease (AD) model. To investigate whether dNAGLU could influence health span, we analyzed the effect of its overexpression on AD flies and found that it improved the climbing ability and stress resistance, including desiccation and hunger, suggesting that dNAGLU improved fly health span. We found that the deposition of Aβ42 in the mushroom body, which is the fly central nervous system, was reduced, and the lysosomal activity in the intestine was increased in dNAGLU over-expressing flies. When NAGLU was overexpressed in human U251-APP cells, which expresses a mutant form of the Aβ-precursor protein (APP), APP-p.M671L, these cells exhibited stronger lysosomal activity and and enhanced expression of lysosomal pathway genes. The concentration of Aβ42 in the cell supernatant was reduced, and the growth arrest caused by APP expression was reversed, suggesting that NAGLU could play a wider role beyond its catalytic activity to enhance lysosomal activity. These results also suggest that NAGLU overexpression could be explored to promote healthy aging and to prevent the onset of neurodegenerative diseases, including AD. To identify new factors that promote longevity and healthy aging, we studied , an ortholog of the human gene, a lysosomal enzyme overexpressed in centenarians. We found that the overexpression of ( ) ubiquitously, or tissue specifically, in the nervous system or fat body could extend fly life span. It also extended the life span of flies overexpressing human Aβ42, in a Alzheimer's disease (AD) model. To investigate whether could influence health span, we analyzed the effect of its overexpression on AD flies and found that it improved the climbing ability and stress resistance, including desiccation and hunger, suggesting that improved fly health span. We found that the deposition of Aβ42 in the mushroom body, which is the fly central nervous system, was reduced, and the lysosomal activity in the intestine was increased in over-expressing flies. When was overexpressed in human U251-APP cells, which expresses a mutant form of the Aβ-precursor protein (APP), APP-p.M671L, these cells exhibited stronger lysosomal activity and and enhanced expression of lysosomal pathway genes. The concentration of Aβ42 in the cell supernatant was reduced, and the growth arrest caused by APP expression was reversed, suggesting that could play a wider role beyond its catalytic activity to enhance lysosomal activity. These results also suggest that overexpression could be explored to promote healthy aging and to prevent the onset of neurodegenerative diseases, including AD. To identify new factors that promote longevity and healthy aging, we studied Drosophila CG13397 , an ortholog of the human NAGLU gene, a lysosomal enzyme overexpressed in centenarians. We found that the overexpression of CG13397 ( dNAGLU ) ubiquitously, or tissue specifically, in the nervous system or fat body could extend fly life span. It also extended the life span of flies overexpressing human Aβ42, in a Drosophila Alzheimer’s disease (AD) model. To investigate whether dNAGLU could influence health span, we analyzed the effect of its overexpression on AD flies and found that it improved the climbing ability and stress resistance, including desiccation and hunger, suggesting that dNAGLU improved fly health span. We found that the deposition of Aβ42 in the mushroom body, which is the fly central nervous system, was reduced, and the lysosomal activity in the intestine was increased in dNAGLU over-expressing flies. When NAGLU was overexpressed in human U251-APP cells, which expresses a mutant form of the Aβ-precursor protein (APP), APP-p.M671L, these cells exhibited stronger lysosomal activity and and enhanced expression of lysosomal pathway genes. The concentration of Aβ42 in the cell supernatant was reduced, and the growth arrest caused by APP expression was reversed, suggesting that NAGLU could play a wider role beyond its catalytic activity to enhance lysosomal activity. These results also suggest that NAGLU overexpression could be explored to promote healthy aging and to prevent the onset of neurodegenerative diseases, including AD. |
Author | Xiao, Fuhui Chen, Kangning Li, Gonghua Kong, Qingpeng Ye, Yunshuang Yang, Ke Li, Yongxuan Smith, Sheryl T Zhou, Jumin Chen, Guijun Xue, Rubing Yang, Liping |
AuthorAffiliation | 1 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Kunming 650223, China 2 Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China 4 Biology Department, Arcadia University, Glenside, PA 19038, USA 3 State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China 5 KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China |
AuthorAffiliation_xml | – name: 2 Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China – name: 4 Biology Department, Arcadia University, Glenside, PA 19038, USA – name: 1 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Kunming 650223, China – name: 3 State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China – name: 5 KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China |
Author_xml | – sequence: 1 givenname: Rubing surname: Xue fullname: Xue, Rubing organization: Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 2 givenname: Ke surname: Yang fullname: Yang, Ke organization: Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 3 givenname: Fuhui surname: Xiao fullname: Xiao, Fuhui organization: State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China – sequence: 4 givenname: Liping surname: Yang fullname: Yang, Liping organization: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Kunming 650223, China – sequence: 5 givenname: Guijun surname: Chen fullname: Chen, Guijun organization: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Kunming 650223, China – sequence: 6 givenname: Yongxuan surname: Li fullname: Li, Yongxuan organization: Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 7 givenname: Yunshuang surname: Ye fullname: Ye, Yunshuang organization: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Kunming 650223, China – sequence: 8 givenname: Kangning surname: Chen fullname: Chen, Kangning organization: Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China – sequence: 9 givenname: Sheryl T surname: Smith fullname: Smith, Sheryl T organization: Biology Department, Arcadia University, Glenside, PA 19038, USA – sequence: 10 givenname: Gonghua orcidid: 0000-0002-9311-6613 surname: Li fullname: Li, Gonghua organization: KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China – sequence: 11 givenname: Qingpeng orcidid: 0000-0002-6046-4494 surname: Kong fullname: Kong, Qingpeng organization: KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China – sequence: 12 givenname: Jumin surname: Zhou fullname: Zhou, Jumin organization: KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650223, China |
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Cites_doi | 10.1126/science.1162011 10.1101/gr.220780.117 10.1080/15548627.2019.1596488 10.1073/pnas.93.12.6101 10.1038/s41573-019-0036-1 10.1016/S0140-6736(20)32205-4 10.18632/aging.202156 10.1124/pr.110.003293 10.1038/cr.2013.70 10.1111/j.1474-9726.2009.00474.x 10.18632/aging.100683 10.3389/fgene.2015.00089 10.1038/nature03029 10.1016/S0140-6736(99)01987-X 10.1111/acel.13120 10.1016/S1474-4422(17)30169-2 10.1016/j.cell.2014.12.016 10.1016/j.tig.2008.10.002 10.1093/gerona/58.3.M232 10.1371/journal.pone.0161817 10.1016/j.exger.2010.08.004 10.1186/s13059-018-1599-6 10.1042/bst0310457 10.1016/j.cmet.2017.08.005 10.3233/JAD-190586 10.1080/15548627.2021.1886720 10.1016/j.cell.2013.05.039 10.1016/0014-5793(93)80398-E 10.1093/hmg/ddq160 10.1111/acel.13069 10.1126/science.1072994 10.1016/j.scitotenv.2020.143290 10.1016/j.jsb.2019.02.005 10.1111/acel.12126 10.1016/j.ymgme.2017.07.005 10.1016/j.arr.2021.101444 10.3390/cells10051054 10.1016/j.exger.2011.12.001 10.1098/rsob.180024 10.3389/fimmu.2021.655478 10.1186/s13024-019-0333-5 10.1073/pnas.1416660111 10.1126/science.1197623 10.1146/annurev-ento-112408-085356 |
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Keywords | longevity Alzheimer’s disease Aβ42 NAGLU healthy aging dNAGLU |
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References | Chandra (ref_39) 2019; 71 Fan (ref_21) 2020; 13 Cuervo (ref_33) 2008; 24 Kan (ref_42) 2014; 111 Peng (ref_46) 2012; 47 Perdok (ref_37) 2021; 71 Song (ref_38) 2020; 19 Gougeon (ref_45) 2021; 12 Tardieu (ref_44) 2017; 16 Kuma (ref_41) 2004; 432 Pandey (ref_26) 2011; 63 Crews (ref_4) 2010; 19 Meijer (ref_15) 2017; 122 Hofmann (ref_22) 2015; 160 Bonam (ref_34) 2019; 18 Xiao (ref_13) 2018; 28 Herskovits (ref_2) 2013; 23 Luo (ref_36) 2019; 16 Zhao (ref_17) 1996; 93 Khorrami (ref_16) 2019; 13 Bonner (ref_27) 2011; 46 Evert (ref_10) 2003; 58 Birrane (ref_14) 2019; 205 Hashimoto (ref_5) 2018; 8 Arrese (ref_29) 2010; 55 Franceschi (ref_11) 2003; 31 ref_25 ref_24 Wang (ref_35) 2021; 761 Wang (ref_18) 2008; 322 Roberts (ref_23) 2017; 26 Fleischer (ref_28) 2018; 19 ref_40 Engberg (ref_12) 2009; 8 Edwards (ref_19) 2014; 6 Omelyanchuk (ref_30) 2015; 6 Demontis (ref_31) 2013; 12 Wu (ref_20) 2020; 19 Hitt (ref_9) 1999; 354 Scheltens (ref_3) 2021; 397 Zheng (ref_43) 2021; 17 Dickson (ref_6) 2019; 14 Blasco (ref_1) 2013; 153 Hardy (ref_7) 2002; 297 Tsukada (ref_32) 1993; 333 Mawuenyega (ref_8) 2010; 330 |
References_xml | – volume: 322 start-page: 957 year: 2008 ident: ref_18 article-title: Fat metabolism links germline stem cells and longevity in C. elegans publication-title: Science doi: 10.1126/science.1162011 contributor: fullname: Wang – volume: 28 start-page: 1601 year: 2018 ident: ref_13 article-title: Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians publication-title: Genome Res. doi: 10.1101/gr.220780.117 contributor: fullname: Xiao – volume: 16 start-page: 52 year: 2019 ident: ref_36 article-title: Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model publication-title: Autophagy doi: 10.1080/15548627.2019.1596488 contributor: fullname: Luo – volume: 93 start-page: 6101 year: 1996 ident: ref_17 article-title: The molecular basis of Sanfilippo syndrome type B publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.93.12.6101 contributor: fullname: Zhao – volume: 18 start-page: 923 year: 2019 ident: ref_34 article-title: Lysosomes as a therapeutic target publication-title: Nat. Rev. Drug Discov. doi: 10.1038/s41573-019-0036-1 contributor: fullname: Bonam – volume: 397 start-page: 1577 year: 2021 ident: ref_3 article-title: Alzheimer’s disease publication-title: Lancet doi: 10.1016/S0140-6736(20)32205-4 contributor: fullname: Scheltens – volume: 13 start-page: 460 year: 2020 ident: ref_21 article-title: Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila publication-title: Aging doi: 10.18632/aging.202156 contributor: fullname: Fan – ident: ref_24 – volume: 63 start-page: 411 year: 2011 ident: ref_26 article-title: Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery publication-title: Pharmacol. Rev. doi: 10.1124/pr.110.003293 contributor: fullname: Pandey – volume: 23 start-page: 746 year: 2013 ident: ref_2 article-title: Sirtuin deacetylases in neurodegenerative diseases of aging publication-title: Cell Res. doi: 10.1038/cr.2013.70 contributor: fullname: Herskovits – volume: 8 start-page: 270 year: 2009 ident: ref_12 article-title: Centenarians—A useful model for healthy aging? A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905 publication-title: Aging Cell doi: 10.1111/j.1474-9726.2009.00474.x contributor: fullname: Engberg – volume: 6 start-page: 621 year: 2014 ident: ref_19 article-title: D-beta-hydroxybutyrate extends lifespan in C. elegans publication-title: Aging doi: 10.18632/aging.100683 contributor: fullname: Edwards – volume: 6 start-page: 89 year: 2015 ident: ref_30 article-title: Drosophila nervous system as a target of aging and anti-aging interventions publication-title: Front. Genet. doi: 10.3389/fgene.2015.00089 contributor: fullname: Omelyanchuk – volume: 432 start-page: 1032 year: 2004 ident: ref_41 article-title: The role of autophagy during the early neonatal starvation period publication-title: Nature doi: 10.1038/nature03029 contributor: fullname: Kuma – volume: 354 start-page: 652 year: 1999 ident: ref_9 article-title: Centenarians: The older you get, the healthier you have been publication-title: Lancet doi: 10.1016/S0140-6736(99)01987-X contributor: fullname: Hitt – volume: 19 start-page: e13120 year: 2020 ident: ref_20 article-title: Sexual dimorphism in the nutritional requirement for adult lifespan in Drosophila melanogaster publication-title: Aging Cell doi: 10.1111/acel.13120 contributor: fullname: Wu – volume: 13 start-page: 173 year: 2019 ident: ref_16 article-title: A novel pathogenic variant in NAGLU (N-Acetyl-Alpha-Glucosaminidase) gene identified by targeted next-generation sequencing followed by in silico analysis publication-title: Iran. J. Child Neurol. contributor: fullname: Khorrami – volume: 16 start-page: 712 year: 2017 ident: ref_44 article-title: Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: An uncontrolled phase 1/2 clinical trial publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(17)30169-2 contributor: fullname: Tardieu – volume: 160 start-page: 477 year: 2015 ident: ref_22 article-title: Reduced expression of MYC increases longevity and enhances healthspan publication-title: Cell doi: 10.1016/j.cell.2014.12.016 contributor: fullname: Hofmann – volume: 24 start-page: 604 year: 2008 ident: ref_33 article-title: Autophagy and aging: Keeping that old broom working publication-title: Trends Genet. doi: 10.1016/j.tig.2008.10.002 contributor: fullname: Cuervo – volume: 58 start-page: M232 year: 2003 ident: ref_10 article-title: Morbidity profiles of centenarians: Survivors, delayers, and escapers publication-title: J. Gerontol. Ser. A doi: 10.1093/gerona/58.3.M232 contributor: fullname: Evert – ident: ref_25 doi: 10.1371/journal.pone.0161817 – volume: 46 start-page: 335 year: 2011 ident: ref_27 article-title: Drosophila as a model to study age-related neurodegenerative disorders: Alzheimer’s disease publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2010.08.004 contributor: fullname: Bonner – volume: 19 start-page: 221 year: 2018 ident: ref_28 article-title: Predicting age from the transcriptome of human dermal fibroblasts publication-title: Genome Biol. doi: 10.1186/s13059-018-1599-6 contributor: fullname: Fleischer – volume: 31 start-page: 457 year: 2003 ident: ref_11 article-title: Centenarians as a model for healthy aging publication-title: Biochem. Soc. Trans. doi: 10.1042/bst0310457 contributor: fullname: Franceschi – volume: 26 start-page: 539 year: 2017 ident: ref_23 article-title: A ketogenic diet extends longevity and healthspan in adult mice publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.08.005 contributor: fullname: Roberts – volume: 71 start-page: 389 year: 2019 ident: ref_39 article-title: PPAR alpha between aspirin and plaque clearance publication-title: J. Alzheimer’s Dis. doi: 10.3233/JAD-190586 contributor: fullname: Chandra – volume: 17 start-page: 3833 year: 2021 ident: ref_43 article-title: Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB) publication-title: Autophagy doi: 10.1080/15548627.2021.1886720 contributor: fullname: Zheng – volume: 153 start-page: 1194 year: 2013 ident: ref_1 article-title: The hallmarks of aging publication-title: Cell doi: 10.1016/j.cell.2013.05.039 contributor: fullname: Blasco – volume: 333 start-page: 169 year: 1993 ident: ref_32 article-title: Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae publication-title: FEBS Lett. doi: 10.1016/0014-5793(93)80398-E contributor: fullname: Tsukada – volume: 19 start-page: R12 year: 2010 ident: ref_4 article-title: Molecular mechanisms of neurodegeneration in Alzheimer’s disease publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq160 contributor: fullname: Crews – volume: 19 start-page: e13069 year: 2020 ident: ref_38 article-title: A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer’s disease models publication-title: Aging Cell doi: 10.1111/acel.13069 contributor: fullname: Song – volume: 297 start-page: 353 year: 2002 ident: ref_7 article-title: The amyloid hypothesis of Alzheimer’s disease_progress and problems on the road to therapeutics publication-title: Science doi: 10.1126/science.1072994 contributor: fullname: Hardy – volume: 761 start-page: 143290 year: 2021 ident: ref_35 article-title: Atmospheric particulate matter impedes autophagic flux by impairing lysosomal milieu and integrity in human umbilical vein endothelial cells (HUVECs) publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2020.143290 contributor: fullname: Wang – volume: 205 start-page: 65 year: 2019 ident: ref_14 article-title: Structural characterization of the alpha-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2019.02.005 contributor: fullname: Birrane – volume: 12 start-page: 943 year: 2013 ident: ref_31 article-title: The influence of skeletal muscle on systemic aging and lifespan publication-title: Aging Cell doi: 10.1111/acel.12126 contributor: fullname: Demontis – volume: 122 start-page: 100 year: 2017 ident: ref_15 article-title: Processing of mutant N -acetyl-α-glucosaminidase in mucopolysaccharidosis type IIIB fibroblasts cultured at low temperature publication-title: Mol. Genet. Metab. doi: 10.1016/j.ymgme.2017.07.005 contributor: fullname: Meijer – volume: 71 start-page: 101444 year: 2021 ident: ref_37 article-title: The microglial lysosomal system in Alzheimer’s disease: Guardian against proteinopathy publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2021.101444 contributor: fullname: Perdok – ident: ref_40 doi: 10.3390/cells10051054 – volume: 47 start-page: 170 year: 2012 ident: ref_46 article-title: Blueberry extract prolongs lifespan of Drosophila melanogaster publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2011.12.001 contributor: fullname: Peng – volume: 8 start-page: 180024 year: 2018 ident: ref_5 article-title: Critical review: Involvement of endoplasmic reticulum stress in the aetiology of Alzheimer’s disease publication-title: Open Biol. doi: 10.1098/rsob.180024 contributor: fullname: Hashimoto – volume: 12 start-page: 655478 year: 2021 ident: ref_45 article-title: Cell-mediated immunity to NAGLU transgene following intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.655478 contributor: fullname: Gougeon – volume: 14 start-page: 32 year: 2019 ident: ref_6 article-title: The neuropathological diagnosis of Alzheimer’s disease publication-title: Mol. Neurodegener. doi: 10.1186/s13024-019-0333-5 contributor: fullname: Dickson – volume: 111 start-page: 14870 year: 2014 ident: ref_42 article-title: Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1416660111 contributor: fullname: Kan – volume: 330 start-page: 1774 year: 2010 ident: ref_8 article-title: Decreased clearance of CNS beta-amyloid in Alzheimer’s disease publication-title: Science doi: 10.1126/science.1197623 contributor: fullname: Mawuenyega – volume: 55 start-page: 207 year: 2010 ident: ref_29 article-title: Insect fat body: Energy, metabolism, and regulation publication-title: Annu. Rev. Entomol. doi: 10.1146/annurev-ento-112408-085356 contributor: fullname: Arrese |
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Snippet | To identify new factors that promote longevity and healthy aging, we studied
, an ortholog of the human
gene, a lysosomal enzyme overexpressed in centenarians.... To identify new factors that promote longevity and healthy aging, we studied Drosophila CG13397, an ortholog of the human NAGLU gene, a lysosomal enzyme... To identify new factors that promote longevity and healthy aging, we studied Drosophila CG13397 , an ortholog of the human NAGLU gene, a lysosomal enzyme... |
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SubjectTerms | Age Aged, 80 and over Aging Alzheimer Disease - genetics Alzheimer's disease Amyloid precursor protein Animals Autophagy Aβ42 Catalytic activity Centenarians Central nervous system Climbing Desiccation dNAGLU Drosophila Drosophila - genetics Exercise Fat body Fruit flies Gene expression Geriatrics healthy aging Heparan sulfate Humans Insects Intestine Life span longevity Longevity - genetics Lysosomes Mushroom bodies NAGLU NAGLU gene Nervous system Oldest old people Proteins Statistical analysis |
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Title | dNAGLU Extends Life Span and Promotes Fitness and Stress Resistance in Drosophila |
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