TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination - Ho, Wan Yun; Chang, Jer-Cherng; Lim, Kenneth; Cazenave-Gassiot, Amaury; Nguyen, Aivi T.; Foo, Juat Chin; Muralidharan, Sneha; Viera-Ortiz, Ashley; Ong, Sarah J.M.; Hor, Jin Hui; Agrawal, Ira; Hoon, Shawn; et al. (The Journal of cell biology, 2021)
Keywords: Amyotrophic lateral sclerosis; Animals; Biosynthesis; Central nervous system; Cholesterol; Cholesterol - metabolism; Dementia disorders; Demyelination; Depletion; Disease Models, Animal; DNA-Binding Proteins - deficiency; DNA-Binding Proteins - genetics; Female; Frontal Lobe - metabolism; Frontal Lobe - pathology; Frontotemporal dementia; Frontotemporal Dementia - genetics; Frontotemporal Dementia - metabolism; Frontotemporal Dementia - pathology; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Synthase - genetics; Hydroxymethylglutaryl-CoA Synthase - metabolism; Lipid metabolism; Lipid Metabolism - genetics; Male; Membrane and lipid biology; Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin; Myelin Sheath - metabolism; Myelin Sheath - pathology; Myelination; Neuroscience; Oligodendrocytes; Oligodendroglia - metabolism; Oligodendroglia - pathology; Organoids - metabolism; Organoids - pathology; Physiology; Primary Cell Culture; Proteins; Receptors, LDL - genetics; Receptors, LDL - metabolism; RNA biology; Signal Transduction; Spinal Cord - metabolism; Spinal Cord - pathology; Sterol Regulatory Element Binding Protein 2 - genetics; Sterol Regulatory Element Binding Protein 2 - metabolism; Supplements; Temporal Lobe - metabolism; Temporal Lobe - pathology; Transcription