Immunogenicity and Protective Efficacy of Radiation-Attenuated and Chemo-Attenuated PfSPZ Vaccines in Equatoguinean Adults

• Published in: The American journal of tropical medicine and hygiene Vol. 104; no. 1; pp. 283 - 293
• Main Authors: Jongo, Said A., Urbano, Vicente, Church, L. W. Preston, Olotu, Ally, Manock, Stephen R., Schindler, Tobias, Mtoro, Ali, KC, Natasha, Hamad, Ali, Nyakarungu, Elizabeth, Mpina, Maximillian, Deal, Anna, Bijeri, José Raso, Ondo Mangue, Martin Eka, Ntutumu Pasialo, Beltrán Ekua, Nguema, Genaro Nsue, Owono, Salomon Nguema, Rivas, Matilde Riloha, Chemba, Mwajuma, Kassim, Kamaka R., James, Eric R., Stabler, Thomas C., Abebe, Yonas, Saverino, Elizabeth, Sax, Julian, Hosch, Salome, Tumbo, Anneth-Mwasi, Gondwe, Linda, Segura, J. Luis, Falla, Carlos Cortes, Phiri, Wonder Philip, Hergott, Dianna E. B., García, Guillermo A., Schwabe, Christopher, Maas, Carl D., Murshedkar, Tooba, Billingsley, Peter F., Tanner, Marcel, Ayekaba, Mitoha Ondo’o, Sim, B. Kim Lee, Daubenberger, Claudia, Richie, Thomas L., Abdulla, Salim, Hoffman, Stephen L.
• Format: Journal Article
• Language: English
• Published: United States Institute of Tropical Medicine 01.01.2021; The American Society of Tropical Medicine and Hygiene
• Subjects: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Antimalarials - therapeutic use; Child; Child, Preschool; Chloroquine - therapeutic use; Double-Blind Method; Equatorial Guinea - epidemiology; Erythrocytes; Female; Humans; Immunization; Immunogenicity, Vaccine; Infant; Malaria Vaccines - adverse effects; Malaria Vaccines - immunology; Malaria, Falciparum - prevention & control; Male; Middle Aged; Parasitemia; Plasmodium falciparum - immunology; Radiation; Vaccines; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; Young Adult; Equatorial Guinea

Plasmodium falciparum sporozoite (PfSPZ) Vaccine (radiation-attenuated, aseptic, purified, cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ administered to subjects taking weekly chloroquine chemoprophylaxis) have shown vaccine efficacies (VEs) of 100% against...