Activating Transcription Factor 3 Protects against Restraint Stress-Induced Gastrointestinal Injury in Mice

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 12; p. 3530
• Main Authors: Chuang, Dun-Jie, Pethaperumal, Subhashree, Siwakoti, Bijaya, Chien, Hung-Jen, Cheng, Ching-Feng, Hung, Shih-Che, Lien, Te-Sheng, Sun, Der-Shan, Chang, Hsin-Hou
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.12.2021; MDPI
• Subjects: Activating transcription factor 3; Activating Transcription Factor 3 - deficiency; Activating Transcription Factor 3 - metabolism; Animals; Antibodies; ATF3; Caspase 3 - metabolism; Cell death; Chromatography; Duodenum - drug effects; Duodenum - metabolism; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Flow cytometry; Gastrointestinal Diseases - blood; Gastrointestinal Diseases - etiology; Gastrointestinal tract; Gene expression; Gene Expression Regulation; gut epithelial cell; Homeostasis; intestinal leakage; Laboratory animals; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerves; Phenotypes; Proton Pump Inhibitors - pharmacology; Restraint, Physical; RNA, Messenger - genetics; RNA, Messenger - metabolism; Small intestine; Stomach; Stress, Psychological - blood; Stress, Psychological - complications; tight junction; Tight Junction Proteins - genetics; Tight Junction Proteins - metabolism; Transcription factors; Ulcers; United States > US; Taiwan; gastrointestinal tract; cell death; gut epithelial cell; intestinal leakage; stress ulcer; ATF3; tight junction

Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute stress leads to GI ulcers; however, the mechanism of the native cellular protection pathway, which safeguards tissue integrality and maintain...