Activating Transcription Factor 3 Protects against Restraint Stress-Induced Gastrointestinal Injury in Mice

Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute stress leads to GI ulcers; however, the mechanism of the native cellular protection pathway, which safeguards tissue integrality and maintain...

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Published inCells (Basel, Switzerland) Vol. 10; no. 12; p. 3530
Main Authors Chuang, Dun-Jie, Pethaperumal, Subhashree, Siwakoti, Bijaya, Chien, Hung-Jen, Cheng, Ching-Feng, Hung, Shih-Che, Lien, Te-Sheng, Sun, Der-Shan, Chang, Hsin-Hou
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.12.2021
MDPI
Subjects
Activating transcription factor 3
Activating Transcription Factor 3 - deficiency
Activating Transcription Factor 3 - metabolism
Animals
Antibodies
ATF3
Caspase 3 - metabolism
Cell death
Chromatography
Duodenum - drug effects
Duodenum - metabolism
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Flow cytometry
Gastrointestinal Diseases - blood
Gastrointestinal Diseases - etiology
Gastrointestinal tract
Gene expression
Gene Expression Regulation
gut epithelial cell
Homeostasis
intestinal leakage
Laboratory animals
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerves
Phenotypes
Proton Pump Inhibitors - pharmacology
Restraint, Physical
RNA, Messenger - genetics
RNA, Messenger - metabolism
Small intestine
Stomach
Stress, Psychological - blood
Stress, Psychological - complications
tight junction
Tight Junction Proteins - genetics
Tight Junction Proteins - metabolism
Transcription factors
Ulcers
United States > US
Taiwan
gastrointestinal tract
cell death
gut epithelial cell
intestinal leakage
stress ulcer
ATF3
tight junction
Online AccessGet full text

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Abstract Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute stress leads to GI ulcers; however, the mechanism of the native cellular protection pathway, which safeguards tissue integrality and maintains GI homeostasis, remains to be investigated. In a mouse model of this study, restraint stress induced GI leakage, abnormal tight junction protein expression, and cell death of gut epithelial cells. The expression of activating transcription factor 3 (ATF3), a stress-responsive transcription factor, is upregulated in the GI tissues of stressed animals. ATF3-deficient mice displayed an exacerbated phenotype of GI injuries. These results suggested that, in response to stress, ATF3 is part of the native cellular protective pathway in the GI system, which could be a molecular target for managing psychological stress-induced GI tract diseases.
AbstractList Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute stress leads to GI ulcers; however, the mechanism of the native cellular protection pathway, which safeguards tissue integrality and maintains GI homeostasis, remains to be investigated. In a mouse model of this study, restraint stress induced GI leakage, abnormal tight junction protein expression, and cell death of gut epithelial cells. The expression of activating transcription factor 3 (ATF3), a stress-responsive transcription factor, is upregulated in the GI tissues of stressed animals. ATF3-deficient mice displayed an exacerbated phenotype of GI injuries. These results suggested that, in response to stress, ATF3 is part of the native cellular protective pathway in the GI system, which could be a molecular target for managing psychological stress-induced GI tract diseases.
Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute stress leads to GI ulcers; however, the mechanism of the native cellular protection pathway, which safeguards tissue integrality and maintains GI homeostasis, remains to be investigated. In a mouse model of this study, restraint stress induced GI leakage, abnormal tight junction protein expression, and cell death of gut epithelial cells. The expression of activating transcription factor 3 (ATF3), a stress-responsive transcription factor, is upregulated in the GI tissues of stressed animals. ATF3-deficient mice displayed an exacerbated phenotype of GI injuries. These results suggested that, in response to stress, ATF3 is part of the native cellular protective pathway in the GI system, which could be a molecular target for managing psychological stress-induced GI tract diseases.Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute stress leads to GI ulcers; however, the mechanism of the native cellular protection pathway, which safeguards tissue integrality and maintains GI homeostasis, remains to be investigated. In a mouse model of this study, restraint stress induced GI leakage, abnormal tight junction protein expression, and cell death of gut epithelial cells. The expression of activating transcription factor 3 (ATF3), a stress-responsive transcription factor, is upregulated in the GI tissues of stressed animals. ATF3-deficient mice displayed an exacerbated phenotype of GI injuries. These results suggested that, in response to stress, ATF3 is part of the native cellular protective pathway in the GI system, which could be a molecular target for managing psychological stress-induced GI tract diseases.
Author Sun, Der-Shan
Lien, Te-Sheng
Chuang, Dun-Jie
Pethaperumal, Subhashree
Siwakoti, Bijaya
Chien, Hung-Jen
Cheng, Ching-Feng
Chang, Hsin-Hou
Hung, Shih-Che
AuthorAffiliation 2 Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan; chienhj1026@gmail.com
3 Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan; chengcf@mail.tcu.edu.tw
1 Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 970, Taiwan; 104727107@gms.tcu.edu.tw (D.-J.C.); subhashreepethaperumal@gmail.com (S.P.); bijaya2580@gmail.com (B.S.); alan211@mail.tcu.edu.tw (T.-S.L.); dssun@mail.tcu.edu.tw (D.-S.S.)
4 Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
5 Institute of Medical Sciences, Tzu-Chi University, Hualien 970, Taiwan; 102353113@gms.tcu.edu.tw
AuthorAffiliation_xml – name: 3 Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan; chengcf@mail.tcu.edu.tw
– name: 2 Institute of Biotechnology, National Tsing Hua University, Hsinchu 300, Taiwan; chienhj1026@gmail.com
– name: 1 Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 970, Taiwan; 104727107@gms.tcu.edu.tw (D.-J.C.); subhashreepethaperumal@gmail.com (S.P.); bijaya2580@gmail.com (B.S.); alan211@mail.tcu.edu.tw (T.-S.L.); dssun@mail.tcu.edu.tw (D.-S.S.)
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Issue 12
Keywords gastrointestinal tract
cell death
gut epithelial cell
intestinal leakage
stress ulcer
ATF3
tight junction
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Snippet Psychological stress increases the risk of gastrointestinal (GI) tract diseases, which involve bidirectional communication of the GI and nerves systems. Acute...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
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Open Access Repository
Aggregation Database
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Enrichment Source
StartPage 3530
SubjectTerms Activating transcription factor 3
Activating Transcription Factor 3 - deficiency
Activating Transcription Factor 3 - metabolism
Animals
Antibodies
ATF3
Caspase 3 - metabolism
Cell death
Chromatography
Duodenum - drug effects
Duodenum - metabolism
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Flow cytometry
Gastrointestinal Diseases - blood
Gastrointestinal Diseases - etiology
Gastrointestinal tract
Gene expression
Gene Expression Regulation
gut epithelial cell
Homeostasis
intestinal leakage
Laboratory animals
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerves
Phenotypes
Proton Pump Inhibitors - pharmacology
Restraint, Physical
RNA, Messenger - genetics
RNA, Messenger - metabolism
Small intestine
Stomach
Stress, Psychological - blood
Stress, Psychological - complications
tight junction
Tight Junction Proteins - genetics
Tight Junction Proteins - metabolism
Transcription factors
Ulcers
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Title Activating Transcription Factor 3 Protects against Restraint Stress-Induced Gastrointestinal Injury in Mice
URI https://www.ncbi.nlm.nih.gov/pubmed/34944038
https://www.proquest.com/docview/2612765018
https://www.proquest.com/docview/2614243805
https://pubmed.ncbi.nlm.nih.gov/PMC8700235
https://doaj.org/article/9ff00089d3c14884ad0d003fcc3ce9ec
Volume 10
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