Low-cariogenicity of trehalose as a substrate

• Published in: Journal of dentistry Vol. 28; no. 8; pp. 571 - 576
• Main Authors: Neta, T, Takada, K, Hirasawa, M
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2000
• Subjects: Animals; Cariogenic Agents - metabolism; Dental caries; Dental Caries - microbiology; Dental Plaque - chemistry; Fermentation; Glucosyltransferase inhibition; Glucosyltransferases - antagonists & inhibitors; Glucosyltransferases - metabolism; Humans; Hydrogen-Ion Concentration; Lactic Acid - biosynthesis; Low-cariogenicity; Mutans streptococci; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Streptococcus mutans - enzymology; Streptococcus mutans - pathogenicity; Substrate Specificity; Sucrose - metabolism; Trehalose; Trehalose - metabolism; Dental caries; Mutans streptococci; Glucosyltransferase inhibition; Low-cariogenicity; Trehalose

Objectives: The effects of trehalose on cariogenesis by mutans streptococci were investigated. Methods: Inhibited effect of trehalose on water-insoluble glucan (WIG) synthesis from sucrose by glucosyltransferase (GTase) of mutans streptococci was assayed. The acid fermentability of trehalose by muta...