Epidermal growth factor receptor signaling mediates aldosterone-induced profibrotic responses in kidney

• Published in: Experimental cell research Vol. 346; no. 1; pp. 99 - 110
• Main Authors: Sheng, Lili, Yang, Min, Ding, Wei, Zhang, Minmin, Niu, Jianying, Qiao, Zhongdong, Gu, Yong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016; Elsevier BV
• Subjects: 60 APPLIED LIFE SCIENCES; ALDOSTERONE; Aldosterone - adverse effects; ANIMAL TISSUES; Animals; Cell Line; Cell Movement - drug effects; CELL PROLIFERATION; Cell Proliferation - drug effects; COLLAGEN; COMPARATIVE EVALUATIONS; DISEASES; Epidermal growth factor receptor; ERK1/2; Erlotinib Hydrochloride - pharmacology; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; FIBROSIS; GROWTH FACTORS; HAZARDS; HYPERTROPHY; INHIBITION; Kidney - drug effects; Kidney - enzymology; Kidney - metabolism; Kidney - pathology; Kidney Glomerulus - drug effects; Kidney Glomerulus - pathology; KIDNEYS; Male; MAP Kinase Signaling System - drug effects; MATRICES; Mesangial Cells - drug effects; Mesangial Cells - pathology; Mice; MIGRATION; Models, Biological; OXIDATION; PHOSPHORYLATION; Phosphorylation - drug effects; PHOSPHOTRANSFERASES; PLANT GROWTH; PLANT TISSUES; POTENTIALS; Profibrotic response; RATS; Rats, Sprague-Dawley; Reactive oxidative stress; Reactive Oxygen Species - metabolism; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - metabolism; RECEPTORS; Receptors, Mineralocorticoid - metabolism; Signal Transduction - drug effects; SIGNALS; STRESSES; Transcriptional Activation - genetics; TYROSINE; ERK1/2; Profibrotic response; Reactive oxidative stress; Aldosterone; Epidermal growth factor receptor

Aldosterone has been recognized as a risk factor for the development of chronic kidney disease (CKD). Studies have indicated that enhanced activation of epidermal growth factor receptor (EGFR) is associated with the development and progression of renal fibrosis. But if EGFR is involved in aldosteron...